Trude Helen FloSenior Research Scientist and Co-director of CEMIR Department of Cancer Research and Molecular Medicine Faculty of Medicine
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Background and activities
Co-Director Centre of Molecular Inflammation Research, head of research group on Molecular Mechanisms of Mycobacterial Infections, teaching immunology, cell bio
Co-director of CEMIR : Centre of Molecular Inflammation Research, a center of excellence at the Faculty of Medicine, NTNU
Senior Research Scientist at Dept. of Cancer Research and Molecular Medicine, NTNU, 2004 - present
Associate Professor II in Immunology at Dept. of Laboratory Medicine, NTNU, 2011 - 2013
- Post doctoral position at Dept. of Cancer Research and Molecular Medicine, NTNU, 2001-2002
PhD (Dr.Philos) in Immunology/Cell Biology at Dept. of Cancer Research and Molecular Medicine, NTNU, 2001
- MSc (sivilingeniør) in Biotechnology at The Norwegian Institute of Technology (NTH, later NTNU), 1995
Research activities and interests
My research is focused on host-pathogen interactions between innate immune cells and bacterial pathogens, e.g. mycobacteria and uropathogenic E. coli. The focus on mycobacteria comes from an interest in Global Health issues, in particular infectious diseases like tuberculosis where the world is in great need for new medications and vaccines, and where our basic research may contribute in revealing new therapeutic or vaccine targets. The macrophage is always in focus, but since the discovery of the anti-bacterial functions of lipocalin 2, I have initiated and contributed in projects exploring the role of lipocalin 2 in infectious diseases or use as a biomarker in diverse conditions.
My research group is part of a larger intitiative on molecular mechanisms of inflammation research, CEMIR.
Scientific, academic and artistic work
A selection of recent journal publications, artistic productions, books, including book and report excerpts. See all publications in the database
- (2013) Dynamics of immune effector mechanisms during infection with Mycobacterium aviumin C57BL/6 mice. Immunology. volum 140 (2).
- (2013) Expression of Toll-like receptor-3 is enhanced in active inflammatory bowel disease and mediates the excessive release of lipocalin 2. Clinical and Experimental Immunology. volum 173 (3).
- (2012) Enhanced levels of CCL19 in patients with advanced acquired immune deficiency syndrome (AIDS). Clinical and Experimental Immunology. volum 167 (3).
- (2012) The association between neutrophil gelatinase-associated lipocalin and clinical outcome in chronic heart failure: results from CORONA. Journal of Internal Medicine. volum 271 (5).
- (2012) Counting mycobacteria in infected human cells and mouse tissue: a comparison between qPCR and CFU. PLoS ONE. volum 7 (4).
- (2010) Intracellular Mycobacterium avium Intersect Transferrin in the Rab11(+) Recycling Endocytic Pathway and Avoid Lipocalin 2 Trafficking to the Lysosomal Pathway. Journal of Infectious Diseases. volum 201 (5).
- (2010) Non-healing is associated with persistent stimulation of the innate immune response in chronic venous leg ulcers. Journal of dermatological science (Amsterdam). volum 59 (2).
- (2009) Relative chemokine and adhesion molecule expression in Mediterranean spotted fever and African tick bite fever. Journal of Infection. volum 58 (1).
- (2009) Increased systemic and myocardial expression of neutrophil gelatinase-associated lipocalin in clinical and experimental heart failure. European Heart Journal. volum 30 (10).
- (2008) Decreased serum lipocalin-2 levels in human immunodeficiency virus-infected patients: increase during highly active anti-retroviral therapy. Clinical and Experimental Immunology. volum 152 (1).
- (2004) Soluble toll-like receptor 2 in HIV infection: association with disease progression. AIDS (London). volum 3 (18).
- (2004) Soluble toll-like receptor 2 in HIV infection: association with disease progression. AIDS (London). volum 18.
- (2004) Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron. Nature. volum 432.
- (2003) Cutting edge: Link between innate and adaptive immunity: toll like receptor 2 (TLR 2) captures antigen for MHC class II presentation to CD4+ T cell responses. Journal of Immunology. volum 171.
- (2003) Cutting edge: link between innate and adaptive immunity: Toll-like receptor 2 internalizes antigen for presentation to CD4+ T cells and could be an efficient vaccine target. Journal of Immunology. volum 171 (1).
- (2002) Heat Shock Proteins and Endotoxin Combined as a Trigger for Inflammatory Cytokine Release During Cardiopulmonary Bypass: A Possible Third Way? Letter til artikkel. Circulation. volum 106.
- (2002) Inflammatory response after open heart surgery: release of heat-shock protein 70 and signaling through toll-like receptor-4. Circulation. volum 105 (6).
- (2002) Induction of cytokine production in human T cells and monocytes by highly purified lipoteichoic acid: involvement of Toll-like receptors and CD14. Medical Science Monitor. volum 8 (5).
- (2002) Involvement of toll-like receptor (TLR) 2 and TLR4 in cell activation by mannuronic acid polymers. Journal of Biological Chemistry. volum 277 (38).
- (2001) Differential expression of Toll-like receptor 2 in human cells. Journal of Leukocyte Biology. volum 69.