Trude Helen FloProfessor in Cell Biology and Co-director of CEMIR Department of Cancer Research and Molecular Medicine Centre of Molecular Inflammation Research (SFF-CEMIR) Faculty of Medicine
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Background and activities
Co-Director Centre of Molecular Inflammation Research and Professor in Cell Biology at Dept of Cancer Research and Molecular Medicine, head of research group on Molecular Mechanisms of Mycobacterial Infections, teaching immunology, cell bio
Professor in Cell Biology at Dept. of Cancer Research and Molecular Medicine, Faculty of Medicine, NTNU,
Co-director of CEMIR : Centre of Molecular Inflammation Research, a center of excellence at the Faculty of Medicine, NTNU
Senior Research Scientist at Dept. of Cancer Research and Molecular Medicine, NTNU, 2004 - present
Associate Professor II in Immunology at Dept. of Laboratory Medicine, NTNU, 2011 - 2013
- Post doctoral position at Dept. of Cancer Research and Molecular Medicine, NTNU, 2001-2002
PhD (Dr.Philos) in Immunology/Cell Biology at Dept. of Cancer Research and Molecular Medicine, NTNU, 2001
- MSc (sivilingeniør) in Biotechnology at The Norwegian Institute of Technology (NTH, later NTNU), 1995
Research activities and interests
My research is focused on host-pathogen interactions between innate immune cells and bacterial pathogens, e.g. mycobacteria and uropathogenic E. coli. The focus on mycobacteria comes from an interest in Global Health issues, in particular infectious diseases like tuberculosis where the world is in great need for new medications and vaccines, and where our basic research may contribute in revealing new therapeutic or vaccine targets. The macrophage is always in focus, but since the discovery of the anti-bacterial functions of lipocalin 2, I have initiated and contributed in projects exploring the role of lipocalin 2 in infectious diseases or use as a biomarker in diverse conditions.
My research group is part of a larger intitiative on molecular mechanisms of inflammation research, CEMIR.
Scientific, academic and artistic work
A selection of recent journal publications, artistic productions, books, including book and report excerpts. See all publications in the database
- (2015) Keap1 regulates inflammatory signaling in Mycobacterium avium-infected human macrophages. Proceedings of the National Academy of Sciences of the United States of America. vol. 112 (31).
- (2015) Seeing a Mycobacterium-Infected Cell in Nanoscale 3D: Correlative Imaging by Light Microscopy and FIB/SEM Tomography. PLoS ONE.
- (2015) TLR8 senses Staphylococcus aureus RNA in human primary monocytes and macrophages and induces IFN-β production via a TAK1-IKKβ-IRF5 signaling pathway. Journal of Immunology. vol. 195 (3).
- (2015) Benzoic acid-Inducible gene expression in mycobacteria. PLoS ONE. vol. 10:e0134544 (9).
- (2014) Lipocalin 2 imparts selective pressure on bacterial growth in the bladder and is elevated in women with urinary tract infection. Journal of Immunology. vol. 193 (12).
- (2013) Dynamics of immune effector mechanisms during infection with Mycobacterium aviumin C57BL/6 mice. Immunology. vol. 140 (2).
- (2013) Expression of Toll-like receptor-3 is enhanced in active inflammatory bowel disease and mediates the excessive release of lipocalin 2. Clinical and Experimental Immunology. vol. 173 (3).
- (2012) Enhanced levels of CCL19 in patients with advanced acquired immune deficiency syndrome (AIDS). Clinical and Experimental Immunology. vol. 167 (3).
- (2012) The association between neutrophil gelatinase-associated lipocalin and clinical outcome in chronic heart failure: results from CORONA. Journal of Internal Medicine. vol. 271 (5).
- (2012) Counting mycobacteria in infected human cells and mouse tissue: a comparison between qPCR and CFU. PLoS ONE. vol. 7 (4).
- (2010) Intracellular Mycobacterium avium Intersect Transferrin in the Rab11(+) Recycling Endocytic Pathway and Avoid Lipocalin 2 Trafficking to the Lysosomal Pathway. Journal of Infectious Diseases. vol. 201 (5).
- (2010) Non-healing is associated with persistent stimulation of the innate immune response in chronic venous leg ulcers. Journal of dermatological science (Amsterdam). vol. 59 (2).
- (2009) Relative chemokine and adhesion molecule expression in Mediterranean spotted fever and African tick bite fever. Journal of Infection. vol. 58 (1).
- (2009) Increased systemic and myocardial expression of neutrophil gelatinase-associated lipocalin in clinical and experimental heart failure. European Heart Journal. vol. 30 (10).
- (2008) Decreased serum lipocalin-2 levels in human immunodeficiency virus-infected patients: increase during highly active anti-retroviral therapy. Clinical and Experimental Immunology. vol. 152 (1).
- (2004) Soluble toll-like receptor 2 in HIV infection: association with disease progression. AIDS (London). vol. 3 (18).
- (2004) Soluble toll-like receptor 2 in HIV infection: association with disease progression. AIDS (London). vol. 18.
- (2004) Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron. Nature. vol. 432.
- (2003) Cutting edge: Link between innate and adaptive immunity: toll like receptor 2 (TLR 2) captures antigen for MHC class II presentation to CD4+ T cell responses. Journal of Immunology. vol. 171.
- (2003) Cutting edge: link between innate and adaptive immunity: Toll-like receptor 2 internalizes antigen for presentation to CD4+ T cells and could be an efficient vaccine target. Journal of Immunology. vol. 171 (1).