Anne Mari A. Rokstad

About

Inflammation, the body’s natural process in early defense of foreign invaders or in endogenous processes as wound healing, is increasingly recognized as an essential player in disease. Behind an inflammatory process are cellular and protein players communicating in complex ways. Depending on the disturbance, different cellular or protein might be involved. To understand these systems could help us understand disease development, point to new treatment options and strategies in the fights against various diseases for improved health and wellbeing.

One major focus of my research is to determine the inflammatory mechanisms of exogenous and endogenous materials. More explained, the exogenous materials could be intentionally uses as for biomaterials and similar applications, including micro- and nanomaterials in medical use. In contrary, it could also be investigations connected to non-intentionally exposure as micro- and nanoplastic particles from daily exposure. The endogenous materials are produced by the body itself and could be exemplified by cholesterol crystals formed in atherosclerotic plaques. Despite different materials, they all impact the immune system through similar as well as unique immune pathways. The overall aim by this research is understanding the inflammatory/immune system at the intersection of materials exposure and use this knowledge for improving our health.

Ongoing projects are currently focusing on understanding the connections between material properties and inflammatory patterns in relation to biomaterials development and cholesterol crystals with relevance in cardiovascular disease. A new-established project investigates the impacts of micro- and nanoplastics to blood reactions.

As a part of these research focuses, we are also investigating the responses following metabolic disease connected to obesity and diabetes.

Research

Inflammation, the body’s natural process in early defence of foreign invaders or in endogenous processes as wound healing, is increasingly recognized as an essential player in disease. Behind an inflammatory process are cellular and protein players communicating in complex ways. Depending on the disturbance, different cellular or protein might be involved. To understand these systems could help us understand disease development, point to new treatment options and strategies in the fights against various diseases for improved health and wellbeing.

One major focus of my research is to determine the inflammatory mechanisms of exogenous and endogenous materials. More explained, the exogenous materials could be intentionally using as for biomaterials and similar applications, including micro- and nanomaterials in medical use. In contrary, it could also be investigations connected to non-intentionally exposure as micro- and nanoplastic particles from daily exposure. The endogenous materials are produced by the body itself and could be exemplified by cholesterol crystals formed in atherosclerotic plaques.

Despite different materials, they all impact the immune system through similar as well as unique immune pathways. The overall aim by this research is understanding the inflammatory/immune system at the intersection of materials exposure and use this knowledge for improving our health.

As a part of these research focuses, we are also investigating the responses following metabolic disease connected to obesity and diabetes.

For a long time, I have also been connected to a global network of researchers aiming at contributing to develop long-term sustainable (fibrosis-free) biodevices for cell therapy in treatment of Type 1 diabetes.

Publications

Type 1 diabetes mellitus (T1DM) does not affect whole blood responses to alginate-based microspheres despite plasma lipid and glucose differences

First study to investigate initial inflammatory capacity between T1DM and controls towards biomaterials, bioparticles and TLR ligands. We find that these responses are similar despite identifying metabolic differences in lipoproteins and metabolites.

MS-proteomics provides insight into the host responses towards alginate microspheres

First study to map host proteins of various alginate microspheres of relevance in cell therapy. Study find differences to inflammatory pathways. Fibrosis free microspheres bind naturally and enrich for anti-complement and anti-coagulation proteins.

Cholesterol crystals induce coagulation activation through complement-dependent expression of monocytic tissue factor

Study showing a link between cholesterol crystals and coagulation activation. Cholesterol crystals found in atherosclerotic plaques could be contributors in thrombosis.

2025

Vasuthas, Kalaiyarasi; Christiansen, Sverre Christian; Kjesbu, Joachim Sebastian; Ryan, Liv; Andreassen, Trygve; Slupphaug, Geir. (2025) Type 1 diabetes mellitus (T1DM) does not affect whole blood responses to alginate-based microspheres despite plasma lipid and glucose differences. Materials Today Bio
Academic article
Lundanes, Julianne; Nes, Vilde Fiske; Aakervik, Oda; Ryan, Liv; Hansson, Patrik; Rokstad, Anne Mari A.. (2025) Changes in Cytokines and Fibrotic Growth Factors after Low-Carbohydrate or Low-Fat Low-Energy Diets in Females with Lipedema. Current Developments in Nutrition (CDN)
Academic article
Vasuthas, Kalaiyarasi; Kjesbu, Joachim Sebastian; Brambilla, Alessandro; Levitan, Maya; Coron, Abba Elizabeth; Fonseca, Davi de Miranda. (2025) Fucoidan alginate and sulfated alginate microbeads induce distinct coagulation, inflammatory and fibrotic responses. Materials Today Bio
Academic article

2024

Dorchei, F.; Heydari, Abolfazl; Kronekovà, Zuzana; Kronek, Juraj; Pelach, Michal; Cseriovà, Zuzana. (2024) Postmodification with Polycations Enhances Key Properties of Alginate-Based Multicomponent Microcapsules. Biomacromolecules
Academic article
Bright, Richard; Visalakshan, Rahul M.; Simon, Johanna; Rokstad, Anne Mari A.; Ghazaryan, Arthur; Morsbach, Svenja. (2024) Manipulation of Serum Protein Adsorption by Nanoengineered Biomaterials Influences Subsequent Immune Responses. ACS Biomaterials Science and Engineering
Academic article
Widerøe, Marius; Falkenberg, Liv Eggset; Cyvin, Jakob Bonnevie; Richter, Isabell; Klingsheim, Karl; Rokstad, Anne Mari A.. (2024) Verdens plastproblem - går det på helsa løs?. Norges teknisk-naturvitenskapelige universitet Norges teknisk-naturvitenskapelige universitet
Report

2022

Coron, Abba Elizabeth; Fonseca, Davi de Miranda; Sharma, Animesh; Slupphaug, Geir; Strand, Berit Løkensgard; Rokstad, Anne Mari A.. (2022) MS-proteomics provides insight into the host responses towards alginate microspheres. Materials Today Bio
Academic article
Syanda, Adam M.; Kringstad, Vera I.; Blackford, Samuel J.I.; Kjesbu, Joachim Sebastian; Ng, Soon Seng; Ma, Liang. (2022) Sulfated alginate reduces pericapsular fibrotic overgrowth on encapsulated cGMP-compliant hPSC-hepatocytes in mice. Frontiers in Bioengineering and Biotechnology
Academic article

2021

Coron, Abba E.; Kjesbu, Joachim Sebastian; Kjærnsmo, Fredrikke; Oberholzer, José; Rokstad, Anne Mari A.; Strand, Berit Løkensgard. (2021) Pericapsular fibrotic overgrowth mitigated in immunocompetent mice through microbead formulations based on sulfated or intermediate G alginates. Acta Biomaterialia
Academic article

2020

Niyonzima, Nathalie; Bakke, Siril Skaret; Gregersen, Ida; Holm, Sverre; Sandanger, Øystein; Orrem, Hilde Lang. (2020) Cholesterol crystals use complement to increase NLRP3 signaling pathways in coronary and carotid atherosclerosis. EBioMedicine
Academic article

2019

Nordli, Henriette R.; Pukstad, Brita; Chinga-Carrasco, Gary; Rokstad, Anne Mari. (2019) Ultrapure Wood Nanocellulose - Assessments of Coagulation and Initial Inflammation Potential. ACS Applied Bio Materials (AABM)
Academic article
Gravastrand, Caroline S.; Steinkjer, Bjørg; Halvorsen, Bente; Landsem, Anne; Skjelland, Mona; Jacobsen, Eva Astrid. (2019) Cholesterol Crystals Induce coagulation Activation through Complement-Dependent Expression of Monocytic Tissue Factor. Journal of Immunology
Academic article

2018

Bochenek, Matthew A.; Veiseh, Omid; Vegas, Arturo J.; McGarrigle, James J.; Qi, Meirigeng; Marchese, Enza. (2018) Alginate encapsulation as long-term immune protection of allogeneic pancreatic islet cells transplanted into the omental bursa of macaques. Nature Biomedical Engineering
Academic article
Kopplin, Georg; Rokstad, Anne Mari; Mélida, Hugo; Bulone, Vincent; Skjåk-Bræk, Gudmund; Aachmann, Finn Lillelund. (2018) Structural characterization of fucoidan from Laminaria hyperborea: Assessment of coagulation and inflammatory properties and their structure−function relationship. ACS Applied Bio Materials (AABM)
Academic article

2017

Wolf-Grosse, Susann; Rokstad, Anne Mari; Ali, Syed; Lambris, JD; Mollnes, Tom Eirik; Nilsen, Asbjørn Magne. (2017) Iron oxide nanoparticles induce cytokine secretion in a complement-dependent manner in a human whole blood model. International Journal of Nanomedicine
Academic article
Gravastrand, Caroline; Hamad, Shamal; Fure, Hilde; Steinkjer, Bjørg; Ryan, Liv; Oberholzer, José. (2017) Alginate microbeads are coagulation compatible, while alginate microcapsules activate coagulation secondary to complement or directly through FXII. Acta Biomaterialia
Academic article
Vaithilingam, Vijayaganapathy; Steinkjer, Bjørg; Ryan, Liv; Larsson, Rolf; Tuch, Bernard E.; Oberholzer, José. (2017) In Vitro and In Vivo Biocompatibility Evaluation of Polyallylamine and Macromolecular Heparin Conjugates Modified Alginate Microbeads. Scientific Reports
Academic article

2016

Arlov, Øystein; Skjåk-Bræk, Gudmund; Rokstad, Anne Mari. (2016) Sulfated alginate microspheres associate with factor H and dampen the inflammatory cytokine response. Acta Biomaterialia
Academic article
Nordli, Henriette R.; Chinga-Carrasco, Gary; Rokstad, Anne Mari; Pukstad, Brita. (2016) Producing ultrapure wood cellulose nanofibrils and evaluating the cytotoxicity using human skin cells. Carbohydrate Polymers
Academic article
Ørning, Mathias Pontus; Hoem, Kine Samset; Coron, Abba Elizabeth; Skjåk-Bræk, Gudmund; Mollnes, Tom Eirik; Brekke, Ole Lars. (2016) Alginate microsphere compositions dictate different mechanisms of complement activation with consequences for cytokine release and leukocyte activation. Journal of Controlled Release
Academic article

2015

Niyonzima, Nathalie; Samstad, Eivind; Aune, Marie Hjelmseth; Ryan, Liv; Bakke, Siril Skaret; Rokstad, Anne Mari. (2015) Reconstituted high-density lipoprotein attenuates cholesterol crystal-induced inflammatory responses by reducing complement activation. Journal of Immunology
Academic article

2014

Sandvig, Ioanna; Karstensen, Kristin; Rokstad, Anne Mari; Aachmann, Finn Lillelund; Formo, Kjetil Ødegård; Sandvig, Axel. (2014) RGD-peptide modified alginate by a chemoenzymatic strategy for tissue engineering applications. Journal of Biomedical Materials Research. Part A
Academic article
Rokstad, Anne Mari; Lacík, Igor; DeVos, Paul; Strand, Berit Løkensgard. (2014) Advances in biocompatibility and physico-chemical characterization of microspheres for cell encapsulation. Advanced Drug Delivery Reviews
Academic literature review

2013

Hals, Ingrid Katrin; Rokstad, Anne Mari; Strand, Berit Løkensgard; Oberholzer, José; Grill, Valdemar. (2013) Alginate Microencapsulation of Human Islets Does Not Increase Susceptibility to Acute Hypoxia. Experimental Diabetes Research
Academic article
Rokstad, Anne Mari; Brekke, Ole Lars; Steinkjer, Bjørg; Ryan, Liv; Kolláriková, Gabriela; Strand, Berit Løkensgard. (2013) The induction of cytokines by polycation containing microspheres by a complement dependent mechanism. Biomaterials
Academic article
Hals, Ingrid Katrin; Rokstad, Anne Mari; Strand, Berit Løkensgard; Grill, Valdemar. (2013) Acute hypoxia impacts similarly on encapsulated and non-encapsulated human pancreatic islets. Diabetologia
Abstract
Rokstad, Anne Mari; Strand, Berit Løkensgard; Espevik, Terje; Mollnes, Tom Eirik. (2013) Biocompatibility and Biotolerability Assessment of Microspheres Using a Whole Blood Model. Micro and Nanosystems
Academic article

2012

Rokstad, Anne Mari; Brekke, Ole Lars; Steinkjer, Bjørg; Ryan, Liv; Kolláriková, Gabriela; Lambris, John D.. (2012) Poly-cation containing alginate microcapsules induce cytokines by a complement-dependent mechanism. Immunobiology
Abstract
Rokstad, Anne Mari; Gustafsson, Björn; Espevik, Terje; Bakke, Ingunn; Pfragner, Roswitha; Svejda, Bernhard. (2012) Microencapsulation of small intestinal neuroendocrine neoplasm cells for tumor model studies. Cancer Science
Academic article

2011

Rokstad, Anne Mari; Brekke, Ole Lars; Steinkjer, Bjørg; Ryan, Liv; Kolláriková, Gabriela; Strand, Berit Løkensgard. (2011) Alginate microbeads are complement compatible, in contrast to polycation containing microcapsules, as revealed in a human whole blood model. Acta Biomaterialia
Academic article

2009

Espevik, Terje; Rokstad, Anne Mari; Kulseng, Bård Eirik; Strand, Berit Løkensgard; Skjåk-Bræk, Gudmund. (2009) Mechanisms of the host immune response to alginate microcapsules.
Chapter

2006

Rokstad, Anne Mari Aukan; Donati, Ivan; Borgogna, Massimiliano; Oberholzer, José; Strand, Berit Løkensgard; Espevik, Terje. (2006) Cell-compatible covalently reinforced beads obtained from a chemoenzymatically engineered alginate. Biomaterials
Academic article
Rokstad, Anne Mari Aukan. (2006) Alginate capsules as bioreactors for cell therapy. Norges teknisk-naturvitenskapelige universitet Doktoravhandlinger ved NTNU, 1503-8181 (2006:24)
Doctoral dissertation

2005

Rokstad, Anne Mari Aukan; Bjerkvig, Rolf; Espevik, Terje; Lund-Johansen, M. (2005) Applications of Cell Immobilisation Biotechnology, Focus on Biotechnology. Book chapter: Cell encapsulation therapy for malignant gliomas. Springer Springer
Academic anthology/Conference proceedings

2003

Rokstad, Anne Mari Aukan; Strand, Berit Løkensgard; Rian, K.; Steinkjer, Bjørg; Kulseng, Bård Eirik; Skjåk-Bræk, Gudmund. (2003) Evaluation of different types of alginate microcapsules as bioreactors for producing endostatin. Cell Transplantation
Academic article
King, Aileen; Strand, Berit Løkensgard; Rokstad, Anne Mari Aukan; Andersson, Arne; Kulseng, Bård Eirik; Skjåk-Bræk, Gudmund. (2003) Improvement of the biocompatibility of alginate/poly-L-lysine/alginate microcapsules by the use of epimerized alginate as a coating. Journal of Biomedical Materials Research
Academic article

2002

Rokstad, Anne Mari Aukan; Holtan, Synnøve; Strand, Berit Løkensgard; Steinkjer, Bjørg; Ryan, Liv; Kulseng, Bård Eirik. (2002) Microencapsulation of cells producing therapeutic proteins: Optimizing cell growth and secretion. Cell Transplantation
Academic article

2001

Rokstad, Anne Mari Aukan; Kulseng, Bård Eirik; Strand, Berit Løkensgard; Skjåk-Bræk, Gudmund; Espevik, Terje. (2001) Transplantation of alginate microcapsules with proliferating cells in mice. Capsular overgrowth and suvival of encapsulated cells of mice and human origin. Annals of the New York Academy of Sciences
Academic article
Strand, Berit Løkensgard; Ryan, Liv; Veld, Peter Int; Kulseng, Bård Eirik; Rokstad, Anne Mari Aukan; Skjåk-Bræk, Gudmund. (2001) Poly-L-Lysine Induces Fibrosis on Alginate Microcapsules via the Induction of Cytokines. Cell Transplantation
Academic article
Read, Tracy-Ann; Farhadi, Mohammed; Bjerkvig, Rolf; Olsen,, Bjørn Reino; Rokstad, Anne Mari; Huszthy, Peter Csaba. (2001) Intravital microscopy reveals novel antivascular and antitumor effects of endostatin delivered locally by alginate-encapsulated cells. Cancer Research
Academic article

2000

Rokstad, Anne Mari Aukan; Skjermo, Jorunn; Skjåk-Bræk, Gudmund; Vadstein, Olav. (2000) Makrofagstudier hos piggvar og kveite etter immunstimulering med FMI in vitro og in vivo. SINTEF fiskeri og havbruk SINTEF fiskeri og havbruk
Report

Journal publications

Vasuthas, Kalaiyarasi; Christiansen, Sverre Christian; Kjesbu, Joachim Sebastian; Ryan, Liv; Andreassen, Trygve; Slupphaug, Geir. (2025) Type 1 diabetes mellitus (T1DM) does not affect whole blood responses to alginate-based microspheres despite plasma lipid and glucose differences. Materials Today Bio
Academic article
Lundanes, Julianne; Nes, Vilde Fiske; Aakervik, Oda; Ryan, Liv; Hansson, Patrik; Rokstad, Anne Mari A.. (2025) Changes in Cytokines and Fibrotic Growth Factors after Low-Carbohydrate or Low-Fat Low-Energy Diets in Females with Lipedema. Current Developments in Nutrition (CDN)
Academic article
Vasuthas, Kalaiyarasi; Kjesbu, Joachim Sebastian; Brambilla, Alessandro; Levitan, Maya; Coron, Abba Elizabeth; Fonseca, Davi de Miranda. (2025) Fucoidan alginate and sulfated alginate microbeads induce distinct coagulation, inflammatory and fibrotic responses. Materials Today Bio
Academic article
Dorchei, F.; Heydari, Abolfazl; Kronekovà, Zuzana; Kronek, Juraj; Pelach, Michal; Cseriovà, Zuzana. (2024) Postmodification with Polycations Enhances Key Properties of Alginate-Based Multicomponent Microcapsules. Biomacromolecules
Academic article
Bright, Richard; Visalakshan, Rahul M.; Simon, Johanna; Rokstad, Anne Mari A.; Ghazaryan, Arthur; Morsbach, Svenja. (2024) Manipulation of Serum Protein Adsorption by Nanoengineered Biomaterials Influences Subsequent Immune Responses. ACS Biomaterials Science and Engineering
Academic article
Coron, Abba Elizabeth; Fonseca, Davi de Miranda; Sharma, Animesh; Slupphaug, Geir; Strand, Berit Løkensgard; Rokstad, Anne Mari A.. (2022) MS-proteomics provides insight into the host responses towards alginate microspheres. Materials Today Bio
Academic article
Syanda, Adam M.; Kringstad, Vera I.; Blackford, Samuel J.I.; Kjesbu, Joachim Sebastian; Ng, Soon Seng; Ma, Liang. (2022) Sulfated alginate reduces pericapsular fibrotic overgrowth on encapsulated cGMP-compliant hPSC-hepatocytes in mice. Frontiers in Bioengineering and Biotechnology
Academic article
Coron, Abba E.; Kjesbu, Joachim Sebastian; Kjærnsmo, Fredrikke; Oberholzer, José; Rokstad, Anne Mari A.; Strand, Berit Løkensgard. (2021) Pericapsular fibrotic overgrowth mitigated in immunocompetent mice through microbead formulations based on sulfated or intermediate G alginates. Acta Biomaterialia
Academic article
Niyonzima, Nathalie; Bakke, Siril Skaret; Gregersen, Ida; Holm, Sverre; Sandanger, Øystein; Orrem, Hilde Lang. (2020) Cholesterol crystals use complement to increase NLRP3 signaling pathways in coronary and carotid atherosclerosis. EBioMedicine
Academic article
Nordli, Henriette R.; Pukstad, Brita; Chinga-Carrasco, Gary; Rokstad, Anne Mari. (2019) Ultrapure Wood Nanocellulose - Assessments of Coagulation and Initial Inflammation Potential. ACS Applied Bio Materials (AABM)
Academic article
Gravastrand, Caroline S.; Steinkjer, Bjørg; Halvorsen, Bente; Landsem, Anne; Skjelland, Mona; Jacobsen, Eva Astrid. (2019) Cholesterol Crystals Induce coagulation Activation through Complement-Dependent Expression of Monocytic Tissue Factor. Journal of Immunology
Academic article
Bochenek, Matthew A.; Veiseh, Omid; Vegas, Arturo J.; McGarrigle, James J.; Qi, Meirigeng; Marchese, Enza. (2018) Alginate encapsulation as long-term immune protection of allogeneic pancreatic islet cells transplanted into the omental bursa of macaques. Nature Biomedical Engineering
Academic article
Kopplin, Georg; Rokstad, Anne Mari; Mélida, Hugo; Bulone, Vincent; Skjåk-Bræk, Gudmund; Aachmann, Finn Lillelund. (2018) Structural characterization of fucoidan from Laminaria hyperborea: Assessment of coagulation and inflammatory properties and their structure−function relationship. ACS Applied Bio Materials (AABM)
Academic article
Wolf-Grosse, Susann; Rokstad, Anne Mari; Ali, Syed; Lambris, JD; Mollnes, Tom Eirik; Nilsen, Asbjørn Magne. (2017) Iron oxide nanoparticles induce cytokine secretion in a complement-dependent manner in a human whole blood model. International Journal of Nanomedicine
Academic article
Gravastrand, Caroline; Hamad, Shamal; Fure, Hilde; Steinkjer, Bjørg; Ryan, Liv; Oberholzer, José. (2017) Alginate microbeads are coagulation compatible, while alginate microcapsules activate coagulation secondary to complement or directly through FXII. Acta Biomaterialia
Academic article
Vaithilingam, Vijayaganapathy; Steinkjer, Bjørg; Ryan, Liv; Larsson, Rolf; Tuch, Bernard E.; Oberholzer, José. (2017) In Vitro and In Vivo Biocompatibility Evaluation of Polyallylamine and Macromolecular Heparin Conjugates Modified Alginate Microbeads. Scientific Reports
Academic article
Arlov, Øystein; Skjåk-Bræk, Gudmund; Rokstad, Anne Mari. (2016) Sulfated alginate microspheres associate with factor H and dampen the inflammatory cytokine response. Acta Biomaterialia
Academic article
Nordli, Henriette R.; Chinga-Carrasco, Gary; Rokstad, Anne Mari; Pukstad, Brita. (2016) Producing ultrapure wood cellulose nanofibrils and evaluating the cytotoxicity using human skin cells. Carbohydrate Polymers
Academic article
Ørning, Mathias Pontus; Hoem, Kine Samset; Coron, Abba Elizabeth; Skjåk-Bræk, Gudmund; Mollnes, Tom Eirik; Brekke, Ole Lars. (2016) Alginate microsphere compositions dictate different mechanisms of complement activation with consequences for cytokine release and leukocyte activation. Journal of Controlled Release
Academic article
Niyonzima, Nathalie; Samstad, Eivind; Aune, Marie Hjelmseth; Ryan, Liv; Bakke, Siril Skaret; Rokstad, Anne Mari. (2015) Reconstituted high-density lipoprotein attenuates cholesterol crystal-induced inflammatory responses by reducing complement activation. Journal of Immunology
Academic article
Sandvig, Ioanna; Karstensen, Kristin; Rokstad, Anne Mari; Aachmann, Finn Lillelund; Formo, Kjetil Ødegård; Sandvig, Axel. (2014) RGD-peptide modified alginate by a chemoenzymatic strategy for tissue engineering applications. Journal of Biomedical Materials Research. Part A
Academic article
Rokstad, Anne Mari; Lacík, Igor; DeVos, Paul; Strand, Berit Løkensgard. (2014) Advances in biocompatibility and physico-chemical characterization of microspheres for cell encapsulation. Advanced Drug Delivery Reviews
Academic literature review
Hals, Ingrid Katrin; Rokstad, Anne Mari; Strand, Berit Løkensgard; Oberholzer, José; Grill, Valdemar. (2013) Alginate Microencapsulation of Human Islets Does Not Increase Susceptibility to Acute Hypoxia. Experimental Diabetes Research
Academic article
Rokstad, Anne Mari; Brekke, Ole Lars; Steinkjer, Bjørg; Ryan, Liv; Kolláriková, Gabriela; Strand, Berit Løkensgard. (2013) The induction of cytokines by polycation containing microspheres by a complement dependent mechanism. Biomaterials
Academic article
Hals, Ingrid Katrin; Rokstad, Anne Mari; Strand, Berit Løkensgard; Grill, Valdemar. (2013) Acute hypoxia impacts similarly on encapsulated and non-encapsulated human pancreatic islets. Diabetologia
Abstract
Rokstad, Anne Mari; Strand, Berit Løkensgard; Espevik, Terje; Mollnes, Tom Eirik. (2013) Biocompatibility and Biotolerability Assessment of Microspheres Using a Whole Blood Model. Micro and Nanosystems
Academic article
Rokstad, Anne Mari; Brekke, Ole Lars; Steinkjer, Bjørg; Ryan, Liv; Kolláriková, Gabriela; Lambris, John D.. (2012) Poly-cation containing alginate microcapsules induce cytokines by a complement-dependent mechanism. Immunobiology
Abstract
Rokstad, Anne Mari; Gustafsson, Björn; Espevik, Terje; Bakke, Ingunn; Pfragner, Roswitha; Svejda, Bernhard. (2012) Microencapsulation of small intestinal neuroendocrine neoplasm cells for tumor model studies. Cancer Science
Academic article
Rokstad, Anne Mari; Brekke, Ole Lars; Steinkjer, Bjørg; Ryan, Liv; Kolláriková, Gabriela; Strand, Berit Løkensgard. (2011) Alginate microbeads are complement compatible, in contrast to polycation containing microcapsules, as revealed in a human whole blood model. Acta Biomaterialia
Academic article
Rokstad, Anne Mari Aukan; Donati, Ivan; Borgogna, Massimiliano; Oberholzer, José; Strand, Berit Løkensgard; Espevik, Terje. (2006) Cell-compatible covalently reinforced beads obtained from a chemoenzymatically engineered alginate. Biomaterials
Academic article
Rokstad, Anne Mari Aukan; Strand, Berit Løkensgard; Rian, K.; Steinkjer, Bjørg; Kulseng, Bård Eirik; Skjåk-Bræk, Gudmund. (2003) Evaluation of different types of alginate microcapsules as bioreactors for producing endostatin. Cell Transplantation
Academic article
King, Aileen; Strand, Berit Løkensgard; Rokstad, Anne Mari Aukan; Andersson, Arne; Kulseng, Bård Eirik; Skjåk-Bræk, Gudmund. (2003) Improvement of the biocompatibility of alginate/poly-L-lysine/alginate microcapsules by the use of epimerized alginate as a coating. Journal of Biomedical Materials Research
Academic article
Rokstad, Anne Mari Aukan; Holtan, Synnøve; Strand, Berit Løkensgard; Steinkjer, Bjørg; Ryan, Liv; Kulseng, Bård Eirik. (2002) Microencapsulation of cells producing therapeutic proteins: Optimizing cell growth and secretion. Cell Transplantation
Academic article
Rokstad, Anne Mari Aukan; Kulseng, Bård Eirik; Strand, Berit Løkensgard; Skjåk-Bræk, Gudmund; Espevik, Terje. (2001) Transplantation of alginate microcapsules with proliferating cells in mice. Capsular overgrowth and suvival of encapsulated cells of mice and human origin. Annals of the New York Academy of Sciences
Academic article
Strand, Berit Løkensgard; Ryan, Liv; Veld, Peter Int; Kulseng, Bård Eirik; Rokstad, Anne Mari Aukan; Skjåk-Bræk, Gudmund. (2001) Poly-L-Lysine Induces Fibrosis on Alginate Microcapsules via the Induction of Cytokines. Cell Transplantation
Academic article
Read, Tracy-Ann; Farhadi, Mohammed; Bjerkvig, Rolf; Olsen,, Bjørn Reino; Rokstad, Anne Mari; Huszthy, Peter Csaba. (2001) Intravital microscopy reveals novel antivascular and antitumor effects of endostatin delivered locally by alginate-encapsulated cells. Cancer Research
Academic article

Books

Rokstad, Anne Mari Aukan; Bjerkvig, Rolf; Espevik, Terje; Lund-Johansen, M. (2005) Applications of Cell Immobilisation Biotechnology, Focus on Biotechnology. Book chapter: Cell encapsulation therapy for malignant gliomas. Springer Springer
Academic anthology/Conference proceedings

Part of book/report

Espevik, Terje; Rokstad, Anne Mari; Kulseng, Bård Eirik; Strand, Berit Løkensgard; Skjåk-Bræk, Gudmund. (2009) Mechanisms of the host immune response to alginate microcapsules.
Chapter

Report

Widerøe, Marius; Falkenberg, Liv Eggset; Cyvin, Jakob Bonnevie; Richter, Isabell; Klingsheim, Karl; Rokstad, Anne Mari A.. (2024) Verdens plastproblem - går det på helsa løs?. Norges teknisk-naturvitenskapelige universitet Norges teknisk-naturvitenskapelige universitet
Report
Rokstad, Anne Mari Aukan. (2006) Alginate capsules as bioreactors for cell therapy. Norges teknisk-naturvitenskapelige universitet Doktoravhandlinger ved NTNU, 1503-8181 (2006:24)
Doctoral dissertation
Rokstad, Anne Mari Aukan; Skjermo, Jorunn; Skjåk-Bræk, Gudmund; Vadstein, Olav. (2000) Makrofagstudier hos piggvar og kveite etter immunstimulering med FMI in vitro og in vivo. SINTEF fiskeri og havbruk SINTEF fiskeri og havbruk
Report

Teaching

Courses

Lectures in following topics;

MD4012 Medicine (IB) Toxicology

MD4020 Medicine (ID) Toxicology, Immunotoxicology and Hypersensitivity Reactions, Immune system in Pregnancy

MD4043 (2D) Seminar Occupational/Environmental Lung Diseases

MOL3005 (Immunology) Barriers and Complement, Allergy and Hypersensitivity Reactions

MOL3018 (Human Toxicology) Immunotoxicology, Developmental Toxicology

MOL3015 (Nanomedicine II) Biomaterials and biocompatiblity, Nanotoxicology

Supervision

PhD projects:

Sofie Altermark, ongoing PhD project entitled: Investigating the thromboinflammatory effects of micro- and nanoplastics using human ex vivo models.

Klayarashi Vasuthas, ongoing project entitled: Tailored biomaterials with reduved immune responses - depicting the material guidance of host the responses.

Abba Elisabeth Coron, thesis entitled: Novel and established algiante hydrogel beads for cell therapy - fibrotic and inflammatory responses with insights from proteomics. Doctoral thesis. https://ntnuopen.ntnu.no/ntnu-xmlui/handle/11250/3112831

Henriette Rogstad Nordlie, thesis entitled: The potential of carboxylated cellulose nanofibrils for wound healing application. Doctoral thesis. https://ntnuopen.ntnu.no/ntnu-xmlui/handle/11250/2640757

Master projects:

Investigating the thromboinflammatory potential of polystyrene micro- and nanoplstics in a human whole blood model. Master thesis in molecular medicine.

Exploration of monocyte responses to stimulation with fucoidan and alginates. Msc Biotechnology. 60 sp.

Investigation of low-grade cytokine responses during weight reduction by low-calorie diets with different carbohydrates and probiotics. Msc Biotechnology. 60 sp.

Cholesterol crystal accumulation at the maternal-fetal interface in preeclampsia. Master thesis in Medicine. https://ntnuopen.ntnu.no/ntnu-xmlui/handle/11250/3128483

The role of cholestrol crystals and LPS in thromboinflammation - combinatory effects and inhibitory potentials. Msc Molecular Medicine. 60 sp. https://ntnuopen.ntnu.no/ntnu-xmlui/handle/11250/2783313

Thromboinflammation - exploring the role of cholesterol crystals and toll-like receptor ligands (2/6, 7, 8) in monocyte tissue factor (TF) expression and inflammation. Msc Molecular Medicine. 60 sp. https://ntnuopen.ntnu.no/ntnu-xmlui/handle/11250/2783312

Cholesterol crystals in cardiovascular disease - exploring their potential impact on monocytes CD14/CD16 and granulocytes CD16 expression. Msc Farmasi. 60 sp. https://ntnuopen.ntnu.no/ntnu-xmlui/handle/11250/2783315

Biocompatibility evaluations of biomaterials in a human whole blood model. Msc Biotechnology. 30 sp.

Obesity weight reduction with focus on complement receptor in expression in blood leukocytes. Msc Molecular Medicine. 60 sp.

Obesity weight reduction and inflammatory leukocyte receptor expresion in blood leukocytes. Msc Molecular Medicine. 60 sp.

Atherosclerotic and obesity-associated inflammation: focus on cholesterol crystals, complement and coagulation. Msc Molecular Medicine. 60 sp.

https://ntnuopen.ntnu.no/ntnu-xmlui/handle/11250/2374503

Atherosclerotic and obesity associated inflammation - impact of weight reduction, cholesterol crystals and complement on FC gamma receptor expression. Msc Molecular Medicine. 60 sp.

Specialized alginates and microcapsules for cell therapy and tissue engineering - focus on immunological properties in a human whole blood model. Msc Biotechnology. 60 sp.

The role of complement in coagulation activation by algiante microspheres in human whole blood model. Msc Biotechnology. 60 sp.

Alginat microcapsules for cell therapy - effects of capsules composition on complement activctivation, cytokine secretion and protein adsoprption in a whole blood model. Msc Bioetechnology. 30 sp.

Outreach

Verdens plastproblem - går det på helsa løs?

Er plast helseskadelig? Denne brosjyren gir ett kort sammendrag av viktige momenter og ubesvarte spørsmål knyttet til plast i ett miljø-helse perspektiv.