Anne Mari Rokstad
Background and activities
Inflammation, the body’s natural process in early defense of foreign invaders or in endogenous processes as wound healing, is increasingly recognized as an essential player in disease. Behind an inflammatory process are cellular and protein players communicating in complex ways. Depending on the disturbance, different cellular or protein players might be involved. To understand these systems could help us developing new treatment points and strategies in the fights against various diseases.
My research focuses are on inflammatory mechanisms of transplanted materials as well as endogenous materials (cholesterol crystals) in cardiovascular disease. Despite different systems, the underlying mechanisms are common and serve as actual intervention points in treatment. Inflammatory mechanisms are also drivers behind obesity related comorbidities as cardiovascular disease, and are thus a part of my research.
Currently, I am exploring future therapeutics in treatment of cardiovascular disease. I am also exploring the effects of diet interventions in obesity inflammation and cardiovascular disease (thrombosis) in collaboration with the Centre for Obesity and Innovation (ObeCe) at St.Olavs University Hospital. My ongoing biomaterials projects are related to diabetes treatment (selecting low-inflammatory materials) as a part of a JDRF supported collaboration project.
Scientific, academic and artistic work
A selection of recent journal publications, artistic productions, books, including book and report excerpts. See all publications in the database
- (2019) Cholesterol Crystals Induce coagulation Activation through Complement-Dependent Expression of Monocytic Tissue Factor. Journal of Immunology. vol. 203 (4).
- (2019) Ultrapure Wood Nanocellulose - Assessments of Coagulation and Initial Inflammation Potential. ACS Applied Bio Materials. vol. 2 (3).
- (2018) Alginate encapsulation as long-term immune protection of allogeneic pancreatic islet cells transplanted into the omental bursa of macaques. Nature Biomedical Engineering. vol. 2.
- (2018) Structural Characterization of Fucoidan from Laminaria hyperborea: Assessment of Coagulation and Inflammatory Properties and Their Structure−Function Relationship. ACS Applied Bio Materials.
- (2017) Alginate microbeads are coagulation compatible, while alginate microcapsules activate coagulation secondary to complement or directly through FXII. Acta Biomaterialia. vol. 58.
- (2017) In Vitro and In Vivo Biocompatibility Evaluation of Polyallylamine and Macromolecular Heparin Conjugates Modified Alginate Microbeads. Scientific Reports. vol. 7 (11695).
- (2017) Iron oxide nanoparticles induce cytokine secretion in a complement-dependent manner in a human whole blood model. International Journal of Nanomedicine. vol. 12.
- (2016) Sulfated alginate microspheres associate with factor H and dampen the inflammatory cytokine response. Acta Biomaterialia. vol. 42.
- (2016) Producing ultrapure wood cellulose nanofibrils and evaluating the cytotoxicity using human skin cells. Carbohydrate Polymers. vol. 150.
- (2016) Alginate microsphere compositions dictate different mechanisms of complement activation with consequences for cytokine release and leukocyte activation. Journal of Controlled Release. vol. 229.
- (2015) Reconstituted high-density lipoprotein attenuates cholesterol crystal-induced inflammatory responses by reducing complement activation. Journal of Immunology. vol. 195 (1).
- (2015) RGD-peptide modified alginate by a chemoenzymatic strategy for tissue engineering applications. Journal of Biomedical Materials Research. Part A. vol. 103 (3).
- (2014) Advances in biocompatibility and physico-chemical characterization of microspheres for cell encapsulation. Advanced Drug Delivery Reviews. vol. 67-68.
- (2013) Acute hypoxia impacts similarly on encapsulated and non-encapsulated human pancreatic islets. Diabetologia. vol. 56.
- (2013) Alginate Microencapsulation of Human Islets Does Not Increase Susceptibility to Acute Hypoxia. Experimental Diabetes Research. vol. 2013.
- (2013) The induction of cytokines by polycation containing microspheres by a complement dependent mechanism. Biomaterials. vol. 34 (3).
- (2013) Biocompatibility and Biotolerability Assessment of Microspheres Using a Whole Blood Model. Micro and Nanosystems. vol. 5 (3).
- (2012) Poly-cation containing alginate microcapsules induce cytokines by a complement-dependent mechanism. Immunobiology. vol. 217 (11).
- (2012) Microencapsulation of small intestinal neuroendocrine neoplasm cells for tumor model studies. Cancer Science. vol. 103 (7).
- (2011) Alginate microbeads are complement compatible, in contrast to polycation containing microcapsules, as revealed in a human whole blood model. Acta Biomaterialia. vol. 7 (6).