Asgeir Kobro-Flatmoen
About
I hold a PhD in Neuroscience on the topic of Alzheimer's disease cell-specific vulnerability, from the Kavli Institute for Systems Neuroscience. I now work as a researcher and co-leader of the K.G. Jebsen Center for Alzheimer's Disease (NTNU).
I am interested in brain function and malfunction and have a particular interest in neurodegeneration. My main focus concerns the how and why Alzheimer’s disease develops, a disease known to heavily target the medial temporal lobe memory system and in particular the entorhinal cortex. Three questions are currently the main focus of my attention: (1) Which neurons show the first sign of subtle pathological change? (2) What are the unique features of these neurons? (3) Are certain types of neurons responsible for spreading the disease to other anatomically connected regions, or do these latter become affected in an independent process?
To address these questions I use animal models and cell culture models. In addition, I work with human brain tissue such that I can relate findings made in models back to the human brain.
Publications
2025
-
Kobro-Flatmoen, Asgeir;
Omholt, Stig William.
(2025)
Intraneuronal binding of amyloid beta with reelin—Implications for the onset of Alzheimer’s disease.
PLoS Computational Biology
Academic article
2024
-
Syversen, Ingrid Framås;
Reznik, Daniel;
Witter, Menno Peter;
Kobro-Flatmoen, Asgeir;
Navarro Schröder, Tobias;
Doeller, Christian Fritz Andreas.
(2024)
A combined DTI-fMRI approach for optimizing the delineation of posteromedial versus anterolateral entorhinal cortex.
Hippocampus
Academic article
-
Omholt, Stig William;
Lejneva, Raissa;
Donate Lagartos, Maria Jose;
Caponio, Domenica;
Fang, Fei;
Kobro-Flatmoen, Asgeir.
(2024)
Bnip3 expression is strongly associated with reelin-positive entorhinal cortex layer II neurons.
Brain Structure and Function
Academic article
-
Hanssen, Katrine Sjaastad;
Winter-Hjelm, Nicolai;
Niethammer, Salome Nora;
Kobro-Flatmoen, Asgeir;
Witter, Menno Peter;
Sandvig, Axel.
(2024)
Reverse engineering of feedforward cortical-Hippocampal microcircuits for modelling neural network function and dysfunction.
Scientific Reports
Academic article
2023
-
Hanssen, Katrine Sjaastad;
Winter-Hjelm, Nicolai;
Niethammer, Salome Nora;
Kobro-Flatmoen, Asgeir;
Witter, Menno Peter;
Sandvig, Axel.
(2023)
Reverse Engineering of Feedforward Cortical-Hippocampal Neural Networks Relevant for Preclinical Disease Modelling.
bioRxiv
Academic article
-
Hanssen, Katrine Sjaastad;
Kobro-Flatmoen, Asgeir;
Sandvig, Ioanna;
Witter, Menno Peter.
(2023)
Dissecting the complexities of Alzheimer's disease. Engineering selectively vulnerable neural networks in vitro.
Norges teknisk-naturvitenskapelige universitet
Doctoral theses at NTNU (365)
Doctoral dissertation
-
Hanssen, Katrine Sjaastad;
Witter, Menno Peter;
Sandvig, Axel;
Sandvig, Ioanna;
Kobro-Flatmoen, Asgeir.
(2023)
Dissection and culturing of adult lateral entorhinal cortex layer II neurons from APP/PS1 Alzheimer model mice.
Journal of Neuroscience Methods
Academic article
-
Kobro-Flatmoen, Asgeir;
Battistin, Claudia;
Raveendran Nair, Rajeevkumar;
Bjorkli, Christiana;
Skender, Belma;
Kentros, Clifford George.
(2023)
Lowering levels of reelin in entorhinal cortex layer II-neurons results in lowered levels of intracellular amyloid-β.
Brain Communications
Academic article
-
Kobro-Flatmoen, Asgeir;
Hormann, Thea Meier;
Gouras, Gunnar.
(2023)
Intracellular Amyloid-β in the Normal Rat Brain and Human Subjects and Its relevance for Alzheimer's Disease.
Journal of Alzheimer's Disease
Academic article
-
Norevik, Cecilie Skarstad;
Huuha, Aleksi Matias;
Røsbjørgen, Ragnhild;
Bergersen, Linda Hildegard;
Jacobsen, Kamilla;
Miguel dos Santos, Rodrigo .
(2023)
Exercised blood plasma promotes hippocampal neurogenesis in the Alzheimer's disease rat brain.
Journal of Sport and Health Science
Academic article
2022
-
Huuha, Aleksi Matias;
Norevik, Cecilie Skarstad;
Moreira, Jose Bianco Nascimento;
Kobro-Flatmoen, Asgeir;
Scrimgeour, Nathan Robert;
Kivipelto, Miia.
(2022)
Can exercise training teach us how to treat Alzheimer's disease?.
Ageing Research Reviews
Academic literature review
-
Hanssen, Katrine Sjaastad;
Witter, Menno;
Sandvig, Axel;
Sandvig, Ioanna;
Kobro-Flatmoen, Asgeir.
(2022)
Microdissection and culturing of adult lateral authorial cortex layer II neurone from APP/PSI Alzheimer model mouse .
bioRxiv
Academic article
-
Tari, Atefe R;
Selbæk, Geir;
Franklin, Barry A.;
Bergh, Sverre;
Skjellegrind, Håvard;
Sallis, Robert E..
(2022)
Temporal changes in personal activity intelligence and the risk of incident dementia and dementia related mortality: A prospective cohort study (HUNT).
EClinicalMedicine
Academic article
2021
-
Syversen, Ingrid Framås;
Witter, Menno;
Kobro-Flatmoen, Asgeir;
Goa, Pål Erik;
Navarro Schröder, Tobias;
Doeller, Christian F..
(2021)
Structural connectivity-based segmentation of the human entorhinal cortex.
NeuroImage
Academic article
-
Roos, Tomas T;
Garcia, Megg G;
Martinsson, Isak;
Mabrouk, Rana;
Israelsson, Bodil;
Deierborg, Tomas.
(2021)
Neuronal spreading and plaque induction of intracellular Aβ and its disruption of Aβ homeostasis.
Acta Neuropathologica
Academic article
-
Kobro-Flatmoen, Asgeir;
Lagartos-Donate, Maria Jose;
Aman, Yahyah;
Edison, Paul;
Witter, Menno;
Fang, Fei.
(2021)
Re-emphasizing early Alzheimer's disease pathology starting in select entorhinal neurons, with a special focus on mitophagy.
Ageing Research Reviews
Academic literature review
2019
-
Tari, Atefe R;
Norevik, Cecilie Skarstad;
Scrimgeour, Nathan Robert;
Kobro-Flatmoen, Asgeir;
Storm-Mathisen, Jon;
Bergersen, Linda Hildegard.
(2019)
Are the Neuroprotective Effects of Exercise Training Systemically Mediated?.
Progress in cardiovascular diseases
Academic literature review
-
Kobro-Flatmoen, Asgeir;
Witter, Menno.
(2019)
Neuronal chemo-architecture of the entorhinal cortex: A comparative review.
European Journal of Neuroscience
Academic literature review
2017
-
Witter, Menno;
Kleven, Heidi;
Kobro-Flatmoen, Asgeir.
(2017)
Comparative Contemplations on the Hippocampus.
Brain, Behavior and Evolution
Academic article
2016
-
Kobro-Flatmoen, Asgeir;
Nagelhus, Anne;
Witter, Menno.
(2016)
Reelin-immunoreactive neurons in entorhinal cortex layer II selectively express intracellular amyloid in early Alzheimer's disease.
Neurobiology of Disease
Academic article
2015
-
Heggland, Ingrid;
Storkaas, Inge;
Soligard, Hanne;
Kobro-Flatmoen, Asgeir;
Witter, Menno.
(2015)
Stereological estimation of neuron number and plaque load in the hippocampal region of a transgenic rat model of Alzheimer's disease.
European Journal of Neuroscience
Academic article
2013
-
Kobro-Flatmoen, Asgeir.
(2013)
Begynnelsen på Alzheimers sykdom.
Website (informational material)
2012
-
Kobro-Flatmoen, Asgeir.
(2012)
NextGen Speaks.
Science
Reader opinion piece
Journal publications
-
Kobro-Flatmoen, Asgeir;
Omholt, Stig William.
(2025)
Intraneuronal binding of amyloid beta with reelin—Implications for the onset of Alzheimer’s disease.
PLoS Computational Biology
Academic article
-
Syversen, Ingrid Framås;
Reznik, Daniel;
Witter, Menno Peter;
Kobro-Flatmoen, Asgeir;
Navarro Schröder, Tobias;
Doeller, Christian Fritz Andreas.
(2024)
A combined DTI-fMRI approach for optimizing the delineation of posteromedial versus anterolateral entorhinal cortex.
Hippocampus
Academic article
-
Omholt, Stig William;
Lejneva, Raissa;
Donate Lagartos, Maria Jose;
Caponio, Domenica;
Fang, Fei;
Kobro-Flatmoen, Asgeir.
(2024)
Bnip3 expression is strongly associated with reelin-positive entorhinal cortex layer II neurons.
Brain Structure and Function
Academic article
-
Hanssen, Katrine Sjaastad;
Winter-Hjelm, Nicolai;
Niethammer, Salome Nora;
Kobro-Flatmoen, Asgeir;
Witter, Menno Peter;
Sandvig, Axel.
(2024)
Reverse engineering of feedforward cortical-Hippocampal microcircuits for modelling neural network function and dysfunction.
Scientific Reports
Academic article
-
Hanssen, Katrine Sjaastad;
Winter-Hjelm, Nicolai;
Niethammer, Salome Nora;
Kobro-Flatmoen, Asgeir;
Witter, Menno Peter;
Sandvig, Axel.
(2023)
Reverse Engineering of Feedforward Cortical-Hippocampal Neural Networks Relevant for Preclinical Disease Modelling.
bioRxiv
Academic article
-
Hanssen, Katrine Sjaastad;
Witter, Menno Peter;
Sandvig, Axel;
Sandvig, Ioanna;
Kobro-Flatmoen, Asgeir.
(2023)
Dissection and culturing of adult lateral entorhinal cortex layer II neurons from APP/PS1 Alzheimer model mice.
Journal of Neuroscience Methods
Academic article
-
Kobro-Flatmoen, Asgeir;
Battistin, Claudia;
Raveendran Nair, Rajeevkumar;
Bjorkli, Christiana;
Skender, Belma;
Kentros, Clifford George.
(2023)
Lowering levels of reelin in entorhinal cortex layer II-neurons results in lowered levels of intracellular amyloid-β.
Brain Communications
Academic article
-
Kobro-Flatmoen, Asgeir;
Hormann, Thea Meier;
Gouras, Gunnar.
(2023)
Intracellular Amyloid-β in the Normal Rat Brain and Human Subjects and Its relevance for Alzheimer's Disease.
Journal of Alzheimer's Disease
Academic article
-
Norevik, Cecilie Skarstad;
Huuha, Aleksi Matias;
Røsbjørgen, Ragnhild;
Bergersen, Linda Hildegard;
Jacobsen, Kamilla;
Miguel dos Santos, Rodrigo .
(2023)
Exercised blood plasma promotes hippocampal neurogenesis in the Alzheimer's disease rat brain.
Journal of Sport and Health Science
Academic article
-
Huuha, Aleksi Matias;
Norevik, Cecilie Skarstad;
Moreira, Jose Bianco Nascimento;
Kobro-Flatmoen, Asgeir;
Scrimgeour, Nathan Robert;
Kivipelto, Miia.
(2022)
Can exercise training teach us how to treat Alzheimer's disease?.
Ageing Research Reviews
Academic literature review
-
Hanssen, Katrine Sjaastad;
Witter, Menno;
Sandvig, Axel;
Sandvig, Ioanna;
Kobro-Flatmoen, Asgeir.
(2022)
Microdissection and culturing of adult lateral authorial cortex layer II neurone from APP/PSI Alzheimer model mouse .
bioRxiv
Academic article
-
Tari, Atefe R;
Selbæk, Geir;
Franklin, Barry A.;
Bergh, Sverre;
Skjellegrind, Håvard;
Sallis, Robert E..
(2022)
Temporal changes in personal activity intelligence and the risk of incident dementia and dementia related mortality: A prospective cohort study (HUNT).
EClinicalMedicine
Academic article
-
Syversen, Ingrid Framås;
Witter, Menno;
Kobro-Flatmoen, Asgeir;
Goa, Pål Erik;
Navarro Schröder, Tobias;
Doeller, Christian F..
(2021)
Structural connectivity-based segmentation of the human entorhinal cortex.
NeuroImage
Academic article
-
Roos, Tomas T;
Garcia, Megg G;
Martinsson, Isak;
Mabrouk, Rana;
Israelsson, Bodil;
Deierborg, Tomas.
(2021)
Neuronal spreading and plaque induction of intracellular Aβ and its disruption of Aβ homeostasis.
Acta Neuropathologica
Academic article
-
Kobro-Flatmoen, Asgeir;
Lagartos-Donate, Maria Jose;
Aman, Yahyah;
Edison, Paul;
Witter, Menno;
Fang, Fei.
(2021)
Re-emphasizing early Alzheimer's disease pathology starting in select entorhinal neurons, with a special focus on mitophagy.
Ageing Research Reviews
Academic literature review
-
Tari, Atefe R;
Norevik, Cecilie Skarstad;
Scrimgeour, Nathan Robert;
Kobro-Flatmoen, Asgeir;
Storm-Mathisen, Jon;
Bergersen, Linda Hildegard.
(2019)
Are the Neuroprotective Effects of Exercise Training Systemically Mediated?.
Progress in cardiovascular diseases
Academic literature review
-
Kobro-Flatmoen, Asgeir;
Witter, Menno.
(2019)
Neuronal chemo-architecture of the entorhinal cortex: A comparative review.
European Journal of Neuroscience
Academic literature review
-
Witter, Menno;
Kleven, Heidi;
Kobro-Flatmoen, Asgeir.
(2017)
Comparative Contemplations on the Hippocampus.
Brain, Behavior and Evolution
Academic article
-
Kobro-Flatmoen, Asgeir;
Nagelhus, Anne;
Witter, Menno.
(2016)
Reelin-immunoreactive neurons in entorhinal cortex layer II selectively express intracellular amyloid in early Alzheimer's disease.
Neurobiology of Disease
Academic article
-
Heggland, Ingrid;
Storkaas, Inge;
Soligard, Hanne;
Kobro-Flatmoen, Asgeir;
Witter, Menno.
(2015)
Stereological estimation of neuron number and plaque load in the hippocampal region of a transgenic rat model of Alzheimer's disease.
European Journal of Neuroscience
Academic article
-
Kobro-Flatmoen, Asgeir.
(2012)
NextGen Speaks.
Science
Reader opinion piece
Report
-
Hanssen, Katrine Sjaastad;
Kobro-Flatmoen, Asgeir;
Sandvig, Ioanna;
Witter, Menno Peter.
(2023)
Dissecting the complexities of Alzheimer's disease. Engineering selectively vulnerable neural networks in vitro.
Norges teknisk-naturvitenskapelige universitet
Doctoral theses at NTNU (365)
Doctoral dissertation
INFORMASJONSMATR
-
Kobro-Flatmoen, Asgeir.
(2013)
Begynnelsen på Alzheimers sykdom.
Website (informational material)
Outreach
2023
-
Programme participationJemterud, Torkild; Kobro-Flatmoen, Asgeir; Moser, Edvard Ingjald; Moser, May Britt; Jacobsen, Ragnhild Irene. (2023) Abels bakgård. NRK P2 NRK P2 [Radio] 2023-02-24
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Academic lectureHanssen, Katrine Sjaastad; Winter-Hjelm, Nicolai; Niethammer, Salome Nora; Kobro-Flatmoen, Asgeir; Witter, Menno Peter; Sandvig, Axel. (2023) Reverse Engineering of Feedforward Cortical-Hippocampal Neural Networks Relevant for Preclinical Disease Modelling. Norwegian Research School in Neuroscience (NRSN) NRSN Norwegian Research School for Neuroscience 10th NRSN Conference , Egersund 2023-09-27 - 2023-09-29
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Popular scientific lectureHanssen, Katrine Sjaastad; Kobro-Flatmoen, Asgeir. (2023) Leve bedre med Alzheimer?. Kavli Insituttet, NTNU Medisin og helse Brain Awareness Week , Trondheim 2023-03-16 - 2023-03-16
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Academic lectureHanssen, Katrine Sjaastad; Winter-Hjelm, Nicolai; Niethammer, Salome Nora; Witter, Menno Peter; Kobro-Flatmoen, Asgeir; Sandvig, Axel. (2023) Reverse Engineering of Feedforward Cortical-Hippocampal Neural Networks Relevant for Preclinical Disease Modelling . Norwegian Research School in Neuroscience (NRSN) 10th Annual PhD Conference in Neuroscience , Egersund, Stavanger, Norway 2023-09-27 - 2023-09-29
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PosterHanssen, Katrine Sjaastad; Winter-Hjelm, Nicolai; Niethammer, Salome Nora; Witter, Menno Peter; Kobro-Flatmoen, Asgeir; Sandvig, Axel. (2023) An in vitro platform to study entorhinal-hippocampal neuronal networks. AD/PD kenes 17th International Conference on Alzheimer’s & Parkinson’s Diseases (AD/PD) , Gothenburg, Sweden 2023-03-28 - 2023-04-01
2022
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Academic lectureHanssen, Katrine Sjaastad; Winter-Hjelm, Nicolai; Sandvig, Axel; Witter, Menno; Kobro-Flatmoen, Asgeir; Sandvig, Ioanna. (2022) An in vitro platform to study entorhinal-hippocampal neural networks . Norwegian Research School for Neuroscience 9th NRSN Conference , Stiklestad 2022-09-28 - 2022-09-30
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PosterHanssen, Katrine Sjaastad; Winter-Hjelm, Nicolai; Sandvig, Axel; Witter, Menno; Kobro-Flatmoen, Asgeir; Sandvig, Ioanna. (2022) An in vitro platform to study adult entorhinal entorhinal-hippocampal neuronal circuits in early Alzheimer's disease. NTNU, Kyoto University JANUBET Symposiym , Kyoto 2022-09-20 - 2022-09-24
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PosterHanssen, Katrine Sjaastad; Sandvig, Ioanna; Sandvig, Axel; Witter, Menno; Kobro-Flatmoen, Asgeir. (2022) An in vitro platform to study adult entorhinal networks in Alzheimer's disease. AD/PD 2022 , Barcelona 2022-03-15 - 2022-03-20
2021
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PosterHanssen, Katrine Sjaastad; Sandvig, Ioanna; Sandvig, Axel; Witter, Menno; Kobro-Flatmoen, Asgeir. (2021) An in vitro platform to study entorhinal networks in Alzheimer’s disease. NRSN NRSN National Neuroscience Symposium 2021-06-29 - 2021-07-01
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PosterBjorkli, Christiana; Hemler, Mary Elisabeth; Ebbessen, Nora Cecilie; Nair, Rajeevkumar Raveendran; Kobro-Flatmoen, Asgeir; Witter, Menno. (2021) Linking molecular biomarkers and behavior in rodent models and patients with Alzheimer’s disease. NRSN National Neuroscience Symposium 2021-06-29 - 2021-07-01
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PosterBjorkli, Christiana; Hemler, Mary Elisabeth; Witter, Menno; Kobro-Flatmoen, Asgeir; Sandvig, Axel; Sandvig, Ioanna. (2021) Linking molecular biomarkers and behavior in rodents and patients with Alzheimer’s disease. The Lancet The Lancet Summit: Presymptomatic Prevention and Treatment of Neurodegenerative Diseases , Virtual 2021-12-14 - 2021-12-16
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PosterBjorkli, Christiana; Hemler, Mary Elisabeth; Ebbesen, Nora Cecilie; Witter, Menno; Nair, Rajeevkumar Raveendran; Kobro-Flatmoen, Asgeir. (2021) Linking molecular biomarkers and behavior in rodents and patients with Alzheimer’s disease. AD/PD AD/PD , Virtual 2021-03-09 - 2021-03-14
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PosterBjorkli, Christiana; Hemler, Mary Elisabeth; Ebbesen, Nora Cecilie; Nair, Rajeevkumar Raveendran; Witter, Menno; Kentros, Clifford. (2021) Linking molecular biomarkers and behavior in preclinical models and patients with Alzheimer's disease. SfN SfN Global Connectome , Virtual 2021-01-11 - 2021-01-13
2020
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PosterHanssen, Katrine Sjaastad; Kobro-Flatmoen, Asgeir; Sandvig, Ioanna; Sandvig, Axel; Witter, Menno. (2020) Developing a novel in vitro platform to study neuronal networks relevant to Alzheimer’s disease. FENS FENS Forum 2020 , Glasgow/Virtual Forum 2020-07-11 - 2020-07-15
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PosterBjorkli, Christiana; Hemler, MB; Raveendran Nair, Rajeevkumar; Kobro-Flatmoen, Asgeir; Witter, Menno; Kentros, Clifford. (2020) Linking molecular biomarkers and behavior in rodents and patients with Alzheimer’s disease . Federation of European Neuroscience Societies FENS Virtual Forum 2020 2020-07-11 - 2020-07-15
2019
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Academic lectureKobro-Flatmoen, Asgeir; Sandvig, Axel; Sandvig, Ioanna; Witter, Menno Peter. (2019) Developing a novel in vitro platform to study Alzheimer’s disease-relevant neuronal networks. Kavli Insititute for Systems Neuroscience Alzheimer's Disease Seminar Series (AD Seminar) , Trondheim, Norway 2019-10-31 - 2019-10-31
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PosterBjorkli, Christiana; Sandvig, Ioanna; Sandvig, Axel; Kentros, Clifford; Witter, Menno; Kobro-Flatmoen, Asgeir. (2019) Linking molecular biomarkers and behaviour in animal models and humans with Alzheimer´s disease. 3rd Nordic Neuroscience Meeting , Helsinki 2019-06-12 - 2019-06-14
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PosterHanssen, Katrine Sjaastad; Kobro-Flatmoen, Asgeir; Sandvig, Ioanna; Sandvig, Axel; Witter, Menno. (2019) Establishing entorhinal cortex layer II neuron cultures as a tool for the investigation of early Alzheimer's disease related changes. Nordic Neuroscience 3rd Nordic Neuroscience Meeting 2019 , Helsinki 2019-06-12 - 2019-06-14
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PosterKobro-Flatmoen, Asgeir; Witter, Menno. (2019) Intracellular Reelin-levels influence the Accumulation of Intracellular Amyloid-β in Reelin-Immunoreactive Neurons in Entorhinal Layer II. Scandinavian Physiological Society 3rd Nordic Neuroscience Meeting , Helsinki 2019-06-02 - 2019-06-04
2014
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PosterKobro-Flatmoen, Asgeir; Cuello, A. Claudio; Witter, Menno. (2014) Reelin-immunoreactive neurons selectively accumulate intracellular Amyloid-Beta during pre-plaque stage in the McGill-R-Thy1-APP model of Alzheimer’s disease. FENS 2014-07-05 - 2014-07-09
2013
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PosterHeggland, Ingrid; Kobro-Flatmoen, Asgeir; Storkaas, Inge; Cuello, C; Witter, Menno. (2013) Neuron number and plaque pathology in the hippocampal and parahippocampal regions of the McGill-R-Thy1-APP transgenic rat model of Alzheimer’s disease. Society for Neuroscience 2013-11-10 -