Asgeir Kobro-Flatmoen
About
I hold a PhD in Neuroscience on the topic of Alzheimer's disease cell-specific vulnerability, from the Kavli Institute for Systems Neuroscience. I now work as a researcher at the K.G. Jebsen Center for Alzheimer's Disease (NTNU).
I am interested in brain function and malfunction and have a particular interest in neurodegeneration. Currently, I focus on the question of how and why Alzheimer’s disease develops, a disease known to heavily target the medial temporal lobe memory system. Three questions are currently the main focus of my attention: 1) Which brain region(s) show the first sign of any pathological change? 2) Are all types of neurons in a given region affected equally by disease-processes during the initial stages? 3) Can certain types of neurons drive the spread of disease to other anatomically connected regions?
Publications
2023
-
Hanssen, Katrine Sjaastad;
Witter, Menno Peter;
Sandvig, Axel;
Sandvig, Ioanna;
Kobro-Flatmoen, Asgeir.
(2023)
Dissection and culturing of adult lateral entorhinal cortex layer II neurons from APP/PS1 Alzheimer model mice.
Journal of Neuroscience Methods.
volum 390.
Academic article
2022
-
Hanssen, Katrine Sjaastad;
Witter, Menno;
Sandvig, Axel;
Sandvig, Ioanna;
Kobro-Flatmoen, Asgeir.
(2022)
Microdissection and culturing of adult lateral authorial cortex layer II neurone from APP/PSI Alzheimer model mouse.
bioRxiv - the preprint server for biology.
Academic article
-
Huuha, Aleksi Matias;
Norevik, Cecilie Skarstad;
Moreira, Jose Bianco Nascimento;
Kobro-Flatmoen, Asgeir;
Scrimgeour, Nathan Robert;
Kivipelto, Miia;
Van Praag, Henriette;
Ziaei, Maryam;
Sando, Sigrid Botne;
Wisløff, Ulrik;
Tari, Atefe R.
(2022)
Can exercise training teach us how to treat Alzheimer's disease?.
Ageing Research Reviews.
volum 75.
Academic literature review
-
Kobro-Flatmoen, Asgeir;
Battistin, Claudia;
Raveendran Nair, Rajeevkumar;
Bjorkli, Christiana;
Skender, Belma;
Kentros, Clifford;
Gouras, Gunnar K;
Witter, Menno.
(2022)
Lowering levels of reelin in entorhinal cortex layer II-neurons results in lowered levels of intracellular amyloid-β.
bioRxiv.
Academic article
-
Tari, Atefe R;
Selbæk, Geir;
Franklin, Barry A.;
Bergh, Sverre;
Skjellegrind, Håvard;
Sallis, Robert E.;
Bosnes, Ingunn;
Stordal, Eystein;
Ziaei, Maryam;
Lydersen, Stian;
Kobro-Flatmoen, Asgeir;
Huuha, Aleksi Matias;
Nauman, Javaid;
Wisløff, Ulrik.
(2022)
Temporal changes in personal activity intelligence and the risk of incident dementia and dementia related mortality: A prospective cohort study (HUNT).
EClinicalMedicine.
volum 52.
Academic article
2021
-
Kobro-Flatmoen, Asgeir;
Lagartos-Donate, Maria Jose;
Aman, Yahyah;
Edison, Paul;
Witter, Menno;
Fang, Fei.
(2021)
Re-emphasizing early Alzheimer's disease pathology starting in select entorhinal neurons, with a special focus on mitophagy.
Ageing Research Reviews.
volum 67.
Academic literature review
-
Roos, Tomas T;
Garcia, Megg G;
Martinsson, Isak;
Mabrouk, Rana;
Israelsson, Bodil;
Deierborg, Tomas;
Kobro-Flatmoen, Asgeir;
Tanila, Heikki;
Gouras, Gunnar K.
(2021)
Neuronal spreading and plaque induction of intracellular Aβ and its disruption of Aβ homeostasis.
Acta Neuropathologica.
volum 142 (4).
Academic article
-
Syversen, Ingrid Framås;
Witter, Menno;
Kobro-Flatmoen, Asgeir;
Goa, Pål Erik;
Navarro Schröder, Tobias;
Doeller, Christian F..
(2021)
Structural connectivity-based segmentation of the human entorhinal cortex.
NeuroImage.
volum 245.
Academic article
2019
-
Kobro-Flatmoen, Asgeir;
Witter, Menno.
(2019)
Neuronal chemo-architecture of the entorhinal cortex: A comparative review.
European Journal of Neuroscience.
volum 50 (10).
Academic literature review
-
Tari, Atefe R;
Norevik, Cecilie Skarstad;
Scrimgeour, Nathan Robert;
Kobro-Flatmoen, Asgeir;
Storm-Mathisen, Jon;
Bergersen, Linda Hildegard;
Wrann, Christiane D.;
Selbæk, Geir;
Kivipelto, Miia;
Moreira, Jose Bianco Nascimento;
Wisløff, Ulrik.
(2019)
Are the Neuroprotective Effects of Exercise Training Systemically Mediated?.
Progress in cardiovascular diseases.
volum 62 (2).
Academic literature review
2017
-
Witter, Menno;
Kleven, Heidi;
Kobro-Flatmoen, Asgeir.
(2017)
Comparative Contemplations on the Hippocampus.
Brain, Behavior and Evolution.
volum 90 (1).
Academic article
2016
-
Kobro-Flatmoen, Asgeir;
Nagelhus, Anne;
Witter, Menno.
(2016)
Reelin-immunoreactive neurons in entorhinal cortex layer II selectively express intracellular amyloid in early Alzheimer's disease.
Neurobiology of Disease.
volum 93.
Academic article
2015
-
Heggland, Ingrid;
Storkaas, Inge;
Soligard, Hanne;
Kobro-Flatmoen, Asgeir;
Witter, Menno.
(2015)
Stereological estimation of neuron number and plaque load in the hippocampal region of a transgenic rat model of Alzheimer's disease.
European Journal of Neuroscience.
volum 41 (9).
Academic article
2013
-
Kobro-Flatmoen, Asgeir.
(2013)
Begynnelsen på Alzheimers sykdom.
Website (informational material)
2012
-
Kobro-Flatmoen, Asgeir.
(2012)
NextGen Speaks.
Science.
volum 335 (6064).
Reader opinion piece
Journal publications
-
Hanssen, Katrine Sjaastad;
Witter, Menno Peter;
Sandvig, Axel;
Sandvig, Ioanna;
Kobro-Flatmoen, Asgeir.
(2023)
Dissection and culturing of adult lateral entorhinal cortex layer II neurons from APP/PS1 Alzheimer model mice.
Journal of Neuroscience Methods.
volum 390.
Academic article
-
Hanssen, Katrine Sjaastad;
Witter, Menno;
Sandvig, Axel;
Sandvig, Ioanna;
Kobro-Flatmoen, Asgeir.
(2022)
Microdissection and culturing of adult lateral authorial cortex layer II neurone from APP/PSI Alzheimer model mouse.
bioRxiv - the preprint server for biology.
Academic article
-
Huuha, Aleksi Matias;
Norevik, Cecilie Skarstad;
Moreira, Jose Bianco Nascimento;
Kobro-Flatmoen, Asgeir;
Scrimgeour, Nathan Robert;
Kivipelto, Miia;
Van Praag, Henriette;
Ziaei, Maryam;
Sando, Sigrid Botne;
Wisløff, Ulrik;
Tari, Atefe R.
(2022)
Can exercise training teach us how to treat Alzheimer's disease?.
Ageing Research Reviews.
volum 75.
Academic literature review
-
Kobro-Flatmoen, Asgeir;
Battistin, Claudia;
Raveendran Nair, Rajeevkumar;
Bjorkli, Christiana;
Skender, Belma;
Kentros, Clifford;
Gouras, Gunnar K;
Witter, Menno.
(2022)
Lowering levels of reelin in entorhinal cortex layer II-neurons results in lowered levels of intracellular amyloid-β.
bioRxiv.
Academic article
-
Tari, Atefe R;
Selbæk, Geir;
Franklin, Barry A.;
Bergh, Sverre;
Skjellegrind, Håvard;
Sallis, Robert E.;
Bosnes, Ingunn;
Stordal, Eystein;
Ziaei, Maryam;
Lydersen, Stian;
Kobro-Flatmoen, Asgeir;
Huuha, Aleksi Matias;
Nauman, Javaid;
Wisløff, Ulrik.
(2022)
Temporal changes in personal activity intelligence and the risk of incident dementia and dementia related mortality: A prospective cohort study (HUNT).
EClinicalMedicine.
volum 52.
Academic article
-
Kobro-Flatmoen, Asgeir;
Lagartos-Donate, Maria Jose;
Aman, Yahyah;
Edison, Paul;
Witter, Menno;
Fang, Fei.
(2021)
Re-emphasizing early Alzheimer's disease pathology starting in select entorhinal neurons, with a special focus on mitophagy.
Ageing Research Reviews.
volum 67.
Academic literature review
-
Roos, Tomas T;
Garcia, Megg G;
Martinsson, Isak;
Mabrouk, Rana;
Israelsson, Bodil;
Deierborg, Tomas;
Kobro-Flatmoen, Asgeir;
Tanila, Heikki;
Gouras, Gunnar K.
(2021)
Neuronal spreading and plaque induction of intracellular Aβ and its disruption of Aβ homeostasis.
Acta Neuropathologica.
volum 142 (4).
Academic article
-
Syversen, Ingrid Framås;
Witter, Menno;
Kobro-Flatmoen, Asgeir;
Goa, Pål Erik;
Navarro Schröder, Tobias;
Doeller, Christian F..
(2021)
Structural connectivity-based segmentation of the human entorhinal cortex.
NeuroImage.
volum 245.
Academic article
-
Kobro-Flatmoen, Asgeir;
Witter, Menno.
(2019)
Neuronal chemo-architecture of the entorhinal cortex: A comparative review.
European Journal of Neuroscience.
volum 50 (10).
Academic literature review
-
Tari, Atefe R;
Norevik, Cecilie Skarstad;
Scrimgeour, Nathan Robert;
Kobro-Flatmoen, Asgeir;
Storm-Mathisen, Jon;
Bergersen, Linda Hildegard;
Wrann, Christiane D.;
Selbæk, Geir;
Kivipelto, Miia;
Moreira, Jose Bianco Nascimento;
Wisløff, Ulrik.
(2019)
Are the Neuroprotective Effects of Exercise Training Systemically Mediated?.
Progress in cardiovascular diseases.
volum 62 (2).
Academic literature review
-
Witter, Menno;
Kleven, Heidi;
Kobro-Flatmoen, Asgeir.
(2017)
Comparative Contemplations on the Hippocampus.
Brain, Behavior and Evolution.
volum 90 (1).
Academic article
-
Kobro-Flatmoen, Asgeir;
Nagelhus, Anne;
Witter, Menno.
(2016)
Reelin-immunoreactive neurons in entorhinal cortex layer II selectively express intracellular amyloid in early Alzheimer's disease.
Neurobiology of Disease.
volum 93.
Academic article
-
Heggland, Ingrid;
Storkaas, Inge;
Soligard, Hanne;
Kobro-Flatmoen, Asgeir;
Witter, Menno.
(2015)
Stereological estimation of neuron number and plaque load in the hippocampal region of a transgenic rat model of Alzheimer's disease.
European Journal of Neuroscience.
volum 41 (9).
Academic article
-
Kobro-Flatmoen, Asgeir.
(2012)
NextGen Speaks.
Science.
volum 335 (6064).
Reader opinion piece
INFORMASJONSMATR
-
Kobro-Flatmoen, Asgeir.
(2013)
Begynnelsen på Alzheimers sykdom.
Website (informational material)
Media
2023
-
Popular scientific lectureHanssen, Katrine Sjaastad; Kobro-Flatmoen, Asgeir. (2023) Leve bedre med Alzheimer?. Brain Awareness Week . Kavli Insituttet, NTNU Medisin og helse; Trondheim. 2023-03-16 - 2023-03-16.
2022
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PosterHanssen, Katrine Sjaastad; Sandvig, Ioanna; Sandvig, Axel; Witter, Menno; Kobro-Flatmoen, Asgeir. (2022) An in vitro platform to study adult entorhinal networks in Alzheimer's disease. AD/PD 2022 ; Barcelona. 2022-03-15 - 2022-03-20.
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PosterHanssen, Katrine Sjaastad; Winter-Hjelm, Nicolai; Sandvig, Axel; Witter, Menno; Kobro-Flatmoen, Asgeir; Sandvig, Ioanna. (2022) An in vitro platform to study adult entorhinal entorhinal-hippocampal neuronal circuits in early Alzheimer's disease. JANUBET Symposiym . NTNU, Kyoto University; Kyoto. 2022-09-20 - 2022-09-24.
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Academic lectureHanssen, Katrine Sjaastad; Winter-Hjelm, Nicolai; Sandvig, Axel; Witter, Menno; Kobro-Flatmoen, Asgeir; Sandvig, Ioanna. (2022) An in vitro platform to study entorhinal-hippocampal neural networks. 9th NRSN Conference . Norwegian Research School for Neuroscience; Stiklestad. 2022-09-28 - 2022-09-30.
2021
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PosterBjorkli, Christiana; Hemler, Mary Elisabeth; Ebbesen, Nora Cecilie; Nair, Rajeevkumar Raveendran; Witter, Menno; Kentros, Clifford; Kobro-Flatmoen, Asgeir; Sandvig, Axel; Sandvig, Ioanna. (2021) Linking molecular biomarkers and behavior in preclinical models and patients with Alzheimer's disease. SfN Global Connectome . SfN; Virtual. 2021-01-11 - 2021-01-13.
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PosterBjorkli, Christiana; Hemler, Mary Elisabeth; Ebbesen, Nora Cecilie; Witter, Menno; Nair, Rajeevkumar Raveendran; Kobro-Flatmoen, Asgeir; Sandvig, Axel; Sandvig, Ioanna. (2021) Linking molecular biomarkers and behavior in rodents and patients with Alzheimer’s disease. AD/PD . AD/PD; Virtual. 2021-03-09 - 2021-03-14.
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PosterBjorkli, Christiana; Hemler, Mary Elisabeth; Ebbessen, Nora Cecilie; Nair, Rajeevkumar Raveendran; Kobro-Flatmoen, Asgeir; Witter, Menno; Sandvig, Axel; Sandvig, Ioanna. (2021) Linking molecular biomarkers and behavior in rodent models and patients with Alzheimer’s disease. NRSN National Neuroscience Symposium ; 2021-06-29 - 2021-07-01.
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PosterBjorkli, Christiana; Hemler, Mary Elisabeth; Witter, Menno; Kobro-Flatmoen, Asgeir; Sandvig, Axel; Sandvig, Ioanna. (2021) Linking molecular biomarkers and behavior in rodents and patients with Alzheimer’s disease. The Lancet Summit: Presymptomatic Prevention and Treatment of Neurodegenerative Diseases . The Lancet; Virtual. 2021-12-14 - 2021-12-16.
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PosterHanssen, Katrine Sjaastad; Sandvig, Ioanna; Sandvig, Axel; Witter, Menno; Kobro-Flatmoen, Asgeir. (2021) An in vitro platform to study entorhinal networks in Alzheimer’s disease. NRSN National Neuroscience Symposium . NRSN; 2021-06-29 - 2021-07-01.
2020
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PosterBjorkli, Christiana; Hemler, MB; Raveendran Nair, Rajeevkumar; Kobro-Flatmoen, Asgeir; Witter, Menno; Kentros, Clifford; Sandvig, Axel; Sandvig, Ioanna. (2020) Linking molecular biomarkers and behavior in rodents and patients with Alzheimer’s disease. FENS Virtual Forum 2020 . Federation of European Neuroscience Societies; 2020-07-11 - 2020-07-15.
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PosterHanssen, Katrine Sjaastad; Kobro-Flatmoen, Asgeir; Sandvig, Ioanna; Sandvig, Axel; Witter, Menno. (2020) Developing a novel in vitro platform to study neuronal networks relevant to Alzheimer’s disease. FENS Forum 2020 . FENS; Glasgow/Virtual Forum. 2020-07-11 - 2020-07-15.
2019
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PosterBjorkli, Christiana; Sandvig, Ioanna; Sandvig, Axel; Kentros, Clifford; Witter, Menno; Kobro-Flatmoen, Asgeir. (2019) Linking molecular biomarkers and behaviour in animal models and humans with Alzheimer´s disease. 3rd Nordic Neuroscience Meeting ; Helsinki. 2019-06-12 - 2019-06-14.
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PosterHanssen, Katrine Sjaastad; Kobro-Flatmoen, Asgeir; Sandvig, Ioanna; Sandvig, Axel; Witter, Menno. (2019) Establishing entorhinal cortex layer II neuron cultures as a tool for the investigation of early Alzheimer's disease related changes. 3rd Nordic Neuroscience Meeting 2019 . Nordic Neuroscience; Helsinki. 2019-06-12 - 2019-06-14.
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PosterKobro-Flatmoen, Asgeir; Witter, Menno. (2019) Intracellular Reelin-levels influence the Accumulation of Intracellular Amyloid-β in Reelin-Immunoreactive Neurons in Entorhinal Layer II. 3rd Nordic Neuroscience Meeting . Scandinavian Physiological Society; Helsinki. 2019-06-02 - 2019-06-04.
2014
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PosterKobro-Flatmoen, Asgeir; Cuello, A. Claudio; Witter, Menno. (2014) Reelin-immunoreactive neurons selectively accumulate intracellular Amyloid-Beta during pre-plaque stage in the McGill-R-Thy1-APP model of Alzheimer’s disease. FENS ; 2014-07-05 - 2014-07-09.
2013
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PosterHeggland, Ingrid; Kobro-Flatmoen, Asgeir; Storkaas, Inge; Cuello, C; Witter, Menno. (2013) Neuron number and plaque pathology in the hippocampal and parahippocampal regions of the McGill-R-Thy1-APP transgenic rat model of Alzheimer’s disease. Society for Neuroscience ; 2013-11-10.