Asgeir Kobro-Flatmoen
Background and activities
I hold a PhD in Neuroscience on the topic of Alzheimer's disease cell-specific vulnerability, from the Kavli Institute for Systems Neuroscience. I now work as a researcher at the K.G. Jebsen Center for Alzheimer's Disease (NTNU).
I am interested in brain function and malfunction and have a particular interest in neurodegeneration. Currently, I focus on the question of how and why Alzheimer’s disease develops, a disease known to heavily target the medial temporal lobe memory system. Three questions are currently the main focus of my attention: 1) Which brain region(s) show the first sign of any pathological change? 2) Are all types of neurons in a given region affected equally by disease-processes during the initial stages? 3) Can certain types of neurons drive the spread of disease to other anatomically connected regions?
Scientific, academic and artistic work
A selection of recent journal publications, artistic productions, books, including book and report excerpts. See all publications in the database
Journal publications
- (2022) Can exercise training teach us how to treat Alzheimer's disease?. Ageing Research Reviews. vol. 75.
- (2022) Lowering levels of reelin in entorhinal cortex layer II-neurons results in lowered levels of intracellular amyloid-β. bioRxiv.
- (2021) Re-emphasizing early Alzheimer's disease pathology starting in select entorhinal neurons, with a special focus on mitophagy. Ageing Research Reviews. vol. 67.
- (2021) Neuronal spreading and plaque induction of intracellular Aβ and its disruption of Aβ homeostasis. Acta Neuropathologica. vol. 142 (4).
- (2021) Structural connectivity-based segmentation of the human entorhinal cortex. NeuroImage. vol. 245.
- (2019) Neuronal chemo-architecture of the entorhinal cortex: A comparative review. European Journal of Neuroscience. vol. 50 (10).
- (2019) Are the Neuroprotective Effects of Exercise Training Systemically Mediated?. Progress in cardiovascular diseases. vol. 62 (2).
- (2017) Comparative Contemplations on the Hippocampus. Brain, Behavior and Evolution. vol. 90 (1).
- (2016) Reelin-immunoreactive neurons in entorhinal cortex layer II selectively express intracellular amyloid in early Alzheimer's disease. Neurobiology of Disease. vol. 93.
- (2015) Stereological estimation of neuron number and plaque load in the hippocampal region of a transgenic rat model of Alzheimer's disease. European Journal of Neuroscience. vol. 41 (9).