Per Bruheim

Professor

Department of Biotechnology and Food Science

per.bruheim@ntnu.no +4741498495

Kjemi 3, 3.124, Gløshaugen, Sem Sælands vei 6, 7034 Trondheim

per.bruheim@ntnu.no

Bruheim group focuses on Deep Phenotyping of prokaryotic and eukaryotic model systems using Advanced Cultivation Technology and Mass Spectrometry based Metabolomics, Fluxomics and Lipidomics (http://www.ntnu.edu/biotech/research/microbial-biotechnology/bruheim-lab). Bruheim is scientific leader of the NT faculty Mass Spectrometry lab (http://www.ntnu.edu/nt-mslab). We have developed a suite of target and non-target MS methods (http://www.ntnu.edu/nt-mslab/metabolomics) which we apply on a range of biological model systems and research questions.

Teaching

Bruheim is Deputy Head of Department with responsibilities in Education and is the leader of the 2-years and 5-years study programs in Biotechnology (MSBIOTECH and MBIOT5). He teaches in TBT4140 Biochemical Engineering, TBT4500 Biotechnology Specialization Project, TBT4110 Microbiology, BT3220 Advanced Biotechnology, TKP4170/71 Process Designs, Projects Biochemical Engineering Plant Design, BT8105 Prokaryote Molecular Biology and Synthetic Biology, MEDT8010 Metabolomics - Methods and Applications

Current projects:

Trond Mohn Stiftelse: “Targeting AMR by inhibition of bacterial stress responses” (2019-2022)

NTNU Biotechnology programme: “Chemically defined cell culture media” (2019-2021)

NFR Digital Life/ Biotek2021: “DigiSal – Towards the Digital Salmon: From a reactive to a pre-emptive research strategy in aquaculture” (2016 - 2020)

NFR Digital Life/ Biotek2021: “INBioPharm - Integrated Novel Natural Product Discovery and Production Platform for Accelerated Biopharmaceutical Innovation from Microbial Biodiversity” (2016 - 2020)

NFR Digital Life/ Biotek2011:” AurOmega - Microbial production of omega-3 fatty acids - a model based approach (2017-2021)

NTNU Helse: “Inhibition of bacterial mutagenesis and attacking a new antibacterial target with novel peptides and small molecules” (2018-2021)

NTNU IBT PhD: “Inhibition of antibiotic resistance development through targeting bacterial translesion synthesis mechanism with novel peptide drugs” (2017-2021)

8-10 ad hoc Metabolomics/ Fluxomics Lipidomics projects (NT-faculty, NTNU, National, International)

Courses

Scientific, academic and artistic work

A selection of recent journal publications, artistic productions, books, including book and report excerpts. See all publications in the database

Journal publications

Jang, Mi; Scheffold, Jana; Røst, Lisa M.; Cheon, Hyejeong; Bruheim, Per. (2022) Serum-free cultures of C2C12 cells show different muscle phenotypes which can be estimated by metabolic profiling. Scientific Reports. vol. 12.
Kumar, Kanhaiya; Bruheim, Per. (2022) A comparative study at bioprocess and metabolite levels of superhost strain Streptomyces coelicolor M1152 and its derivative M1581 heterologously expressing chloramphenicol biosynthetic gene cluster. Biotechnology and Bioengineering. vol. 119.
Kumar, Kanhaiya; Bruheim, Per. (2022) Nutrient-depended metabolic switching during batch cultivation of Streptomyces coelicolor explored with absolute quantitative mass spectrometry based metabolite profiling. 3 Biotech. vol. 12.
Rau, E-Ming; Bartosova, Zdenka; Kristiansen, Kåre Andre; Aasen, Inga Marie; Bruheim, Per; Ertesvåg, Helga. (2022) Overexpression of two new acyl-CoA:diacylglycerol acyltransferase 2-like acyl-CoA:sterol acyltransferases enhanced squalene accumulation in Aurantiochytrium limacinum. Frontiers in Microbiology.
Simensen, Vetle; Schulz, Christian; Karlsen, Emil; Bråtelund, Signe; Burgos, Idun Maria Tokvam; Thorfinnsdottir, Lilja Brekke; García-Calvo, Laura; Bruheim, Per; Almaas, Eivind. (2022) Experimental determination of Escherichia coli biomass composition for constraint-based metabolic modeling. PLOS ONE. vol. 17 (1).
Abdollahi, Pegah; Vandsemb, Esten; Elsaadi, Samah; Røst, Lisa Marie; Yang, Rui; Hjort, Magnus Aassved; Andreassen, Trygve; Misund, Kristine; Slørdahl, Tobias Schmidt; Rø, Torstein Baade; Sponaas, Anne-Marit; Moestue, Siver Andreas; Bruheim, Per; Børset, Magne. (2021) Phosphatase of Regenerating Liver-3 Regulates Cancer Cell Metabolism in Multiple Myeloma. The FASEB Journal.
Bartosova, Zdenka; Ertesvåg, Helga; Nyfløt, Eirin Lishaugen; Kämpe, Kristoffer; Aasen, Inga Marie; Bruheim, Per. (2021) Combined Metabolome and Lipidome analyses for in-depth characterization of lipid accumulation in the DHA producing Aurantiochytrium sp. T66. Metabolites. vol. 11 (3).
Bartosova, Zdenka; Villa Gonzalez, Susana; Voigt, Andre; Bruheim, Per. (2021) High throughput semi-quantitative UHPSFC-MS/MS lipid profiling and lipid class determination. Journal of Chromatographic Science. vol. 59 (7).
Fuchino, Katsuya; Chan, Helena; Hwang, Ling Chin; Bruheim, Per. (2021) The Ethanologenic bacterium Zymomonas mobilis divides asymmetrically and exhibits heterogeneity in DNA content. Applied and Environmental Microbiology. vol. 87 (6).
Gidon, Alexandre; Louet, Claire; Røst, Lisa M.; Bruheim, Per; Flo, Trude Helen. (2021) The Tumor Necrosis Factor Alpha and Interleukin 6 Auto-paracrine Signaling Loop Controls Mycobacterium avium Infection via Induction of IRF1/IRG1 in Human Primary Macrophages. mBio. vol. 12 (5).
Jin, Yang; Harvey, Thomas Nelson; Bartosova, Zdenka; Hassani, Sahar; Bruheim, Per; Sandve, Simen Rød; Vik, Jon Olav. (2021) Diet and Life Stage-Associated Lipidome Remodeling in Atlantic Salmon. Journal of Agricultural and Food Chemistry. vol. 69 (12).
Kumar, Kanhaiya; Bruheim, Per. (2021) Large dependency of intracellular NAD and CoA pools on cultivation conditions in Saccharomyces cerevisiae. BMC Research Notes. vol. 14 (1).
Kumar, Kanhaiya; Venkatraman, Vishwesh; Bruheim, Per. (2021) Adaptation of central metabolite pools to variations in growth rate and cultivation conditions in Saccharomyces cerevisiae. Microbial Cell Factories.
Nilsen, Mona Synnøve; Lindquist, Carine; Stafsnes, Marit Hallvardsdotter; Bjørndal, Bodil; Bruheim, Per; Aloysius, Thomas Aquinas; Nygård, Ottar; Skorve, Jon; Madsen, Lise; Dankel, Simon E Nitter; Berge, Rolf Kristian. (2021) Plasma 3-hydroxyisobutyrate (3-HIB) and methylmalonic acid (MMA) are markers of hepatic mitochondrial fatty acid oxidation in male Wistar rats. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. vol. 1866 (4).
Rutkis, Reinis; Strazdina, Inese; Lasa, Zane; Bruheim, Per; Kalnenieks, Uldis. (2021) Ethanologenesis and respiration in a pyruvate decarboxylase-deficient Zymomonas mobilis. BMC Research Notes. vol. 14.
Skedsmo, Fredrik; Espenes, Arild; Tranulis, Michael A.; Matiasek, Kaspar; Gunnes, Gjermund; Bjerkås, Inge; Moe, Lars; Røed, Susan Skogtvedt; Berendt, Mette; Fredholm, Merete; Rohdin, Cecilia; Shelton, G. Diane; Bruheim, Per; Stafsnes, Marit Hallvardsdotter; Bartosova, Zdenka; Hermansen, Lene Cecilie; Stigen, Øyvind; Jäderlund, Karin Hultin. (2021) Impaired NDRG1 functions in Schwann cells cause demyelinating neuropathy in a dog model of Charcot-Marie-Tooth type 4D. Neuromuscular Disorders. vol. 31 (1).
Sumabe, Balagra Kasim; Ræder, Synnøve Brandt; Røst, Lisa M.; Sharma, Animesh; Donkor, Eric S.; Mosi, Lydia; Duodu, Samuel; Bruheim, Per; Otterlei, Marit. (2021) Nucleoside Analogues Are Potent Inducers of Pol V-mediated Mutagenesis. Biomolecules. vol. 11 (6).
Fontana, Diletta; Mauri, Mario; Renso, Rossella; Docci, Mattia; Crespiatico, Ilaria; Røst, Lisa Marie; Jang, Mi; Niro, Antonio; D’Aliberti, Deborah; Massimino, Luca; Bertagna, Mayla; Zambrotta, Giovanni; Bossi, Mario; Citterio, Stefania; Crescenzi, Barbara; Fanelli, Francesca; Cassina, Valeria; Corti, Roberta; Salerno, Domenico; Nardo, Luca; Chinello, Clizia; Mantegazza, Francesco; Mecucci, Cristina; Magni, Fulvio; Cavaletti, Guido; Bruheim, Per; Rea, Delphine; Larsen, Steen; Gambacorti-Passerini, Carlo; Piazza, Rocco. (2020) ETNK1 mutations induce a mutator phenotype that can be reverted with phosphoethanolamine. Nature Communications. vol. 11.
Fuchino, Katsuya; Bruheim, Per. (2020) An assessment of serial co-cultivation approach for generating novel Zymomonas mobilis strains. BMC Research Notes. vol. 13.
Fuchino, Katsuya; Bruheim, Per. (2020) Increased salt tolerance in Zymomonas mobilis strain generated by adaptative evolution. Microbial Cell Factories. vol. 19 (1).

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