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  1. Employees

Språkvelger

Norsk

Denis Kaynov

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Denis Kaynov

Professor
Department of Clinical and Molecular Medicine
Faculty of Medicine and Health Sciences

denis.kainov@ntnu.no
+4773412547 Trondheim
About Research Publications Teaching Outreach

About

CV

Denis Kainov received his doctorate at the University of Helsinki in 2005. He was a postdoctoral researcher at the Institute of Genetics and Molecular and Cellular Biology (IGBMC) from 2005 to 2007 and at CRP-Santé Luxembourg from 2007 to 2009. He was a researcher and project manager at the University of Helsinki from 2010 to 2016. Now he's a professor at NTNU, Norway.

Competencies

  • Immunity
  • Pharmacology
  • Virology
  • Virus
  • adaptive immunity
  • antiviral drug
  • drug combination
  • drug development
  • drug discovery
  • infection
  • infectious disease
  • innate immunity

Research

Our group develops antiviral drug cocktails to target a wide range of viruses and their drug-resistant variants.

  • Hilde Lysvand
  • Irene Trøen Frøysa

Publications

  • Chronological
  • By category
  • See all publications in Cristin

2025

  • Ravlo, Erlend; Ianevski, Aleksandr; Schjølberg, Jørn-Ove; Solvang, Vanessa; Dumaru, Rabina; Lysvand, Hilde. (2025) Synergistic combination of orally available safe-in-man pleconaril, AG7404, and mindeudesivir inhibits enterovirus infections in human cell and organoid cultures. Cellular and Molecular Life Sciences (CMLS)
    Academic article
  • Kainov, Denis; Ravlo, Erlend; Ianevski, Aleksandr. (2025) Seeking innovative concepts in development of antiviral drug combinations. Antiviral Research
    Academic literature review

2024

  • Andersen, Gøran Troseth; Ianevski, Aleksandr; Resell, Mathilde Victoria; Pojskic, Naris; Rabben, Hanne-Line; Geithus, Synne. (2024) Multi-bioinformatics revealed potential biomarkers and repurposed drugs for gastric adenocarcinoma-related gastric intestinal metaplasia. npj Systems Biology and Applications
    Academic article
  • Halabitska, Iryna; Petakh, Pavlo; Kamyshna, Iryna; Oksenych, Valentyn; Kainov, Denis; Kamyshnyi, Oleksandr. (2024) The interplay of gut microbiota, obesity, and depression: insights and interventions. Cellular and Molecular Life Sciences (CMLS)
    Academic literature review
  • Ianevski, Aleksandr; Frøysa, Irene Trøen; Lysvand, Hilde; Calitz, Carlemi; Smura, Teemu; Nilsen, Hans-Johnny. (2024) The combination of pleconaril, rupintrivir, and remdesivir efficiently inhibits enterovirus infections in vitro, delaying the development of drug-resistant virus variants. Antiviral Research
    Academic article

2023

  • Ravlo, Erlend; Ianevski, Aleksandr; Starheim, Eirin Johannessen; Wang, Wei; Ji, Ping; Lysvand, Hilde. (2023) Boosted production of antibodies that neutralized different SARS-CoV-2 variants in a COVID-19 convalescent following messenger RNA vaccination - a case study. International Journal of Infectious Diseases
    Article in business/trade/industry journal
  • Wang, Yining; Li, Pengfei; Xu, Lei; de Vries, Annemarie C.; Rottier, Robbert J.; Wang, Wenshi. (2023) Combating pan-coronavirus infection by indomethacin through simultaneously inhibiting viral replication and inflammatory response. iScience
    Academic article
  • Hermet, Paule; Delache, Benoît; Herate, Cecile; Wolf, Esther; Kivi, Gaily; Juronen, Erkki. (2023) Broadly neutralizing humanized SARS-CoV-2 antibody binds to a conserved epitope on Spike and provides antiviral protection through inhalation-based delivery in nonhuman primates. PLoS Pathogens
    Academic article
  • Kamyshnyi, Aleksandr; Koval, Halyna; Kobevko, Olha; Buchynskyi, Mykhailo; Oksenych, Valentyn; Kaynov, Denis. (2023) Therapeutic Effectiveness of Interferon-α2b against COVID-19 with Community-Acquired Pneumonia: The Ukrainian Experience. International Journal of Molecular Sciences
    Academic article
  • Petakh, Pavlo; Kamyshna, Iryna; Oksenych, Valentyn; Kainov, Denis; Kamyshnyi, Aleksandr. (2023) Metformin Therapy Changes Gut Microbiota Alpha-Diversity in COVID-19 Patients with Type 2 Diabetes: The Role of SARS-CoV-2 Variants and Antibiotic Treatment. Pharmaceuticals
    Academic article
  • Benjakul, Sopisa; Anthi, Aina Karen; Kolderup, Heidi Anette; Vaysburd, Marina; Lode, Heidrun Elisabeth; Mallery, D. (2023) A pan-SARS-CoV-2-specific soluble angiotensin-converting enzyme 2-albumin fusion engineered for enhanced plasma half-life and needle-free mucosal delivery. PNAS Nexus
    Academic article

2022

  • Pinto, Sneha M.; Subbannayya, Yashwanth; Kim, Hera; Hagen, Lars; Górna, Maria W; Nieminen, Anni I.. (2022) Multi-OMICs landscape of SARS-CoV-2-induced host responses in human lung epithelial cells. iScience
    Academic article
  • Ianevski, Aleksandr; Yao, Rouan; Simonsen, Ronja Meyer; Myhre, Vegard; Ravlo, Erlend; Kaynova, Gerda D.. (2022) Mono- and combinational drug therapies for global viral pandemic preparedness. iScience
    Academic literature review
  • Ravlo, Erlend; Evensen, Lasse; Sanson, Gorm; Hildonen, Siri; Ianevski, Aleksandr; Skjervold, Per Olav. (2022) Antiviral Immunoglobulins of Chicken Egg Yolk for Potential Prevention of SARS-CoV-2 Infection. Viruses
    Academic article
  • Ianevski, Aleksandr; Simonsen, Ronja Meyer; Myhre, Vegard; Tenson, Tanel; Oksenych, Valentyn; Bjørås, Magnar. (2022) DrugVirus.info 2.0: an integrative data portal for broad-spectrum antivirals (BSA) and BSA-containing drug combinations (BCCs). Nucleic Acids Research (NAR)
    Academic article
  • Kainov, Denis; Oksenych, Valentyn. (2022) Broad-Spectrum Antivirals and Antiviral Combinations: An Editorial Update. Viruses
    Editorial
  • Ianevski, Aleksandr; Zusinaite, Eva; Tenson, Tanel; Oksenych, Valentyn; Wang, Wei; Afset, Jan Egil. (2022) Novel Synergistic Anti-Enteroviral Drug Combinations. Viruses
    Academic article
  • Ianevski, Aleksandr; Ahmad, Shahzaib; Anunnitipat, Kraipit; Oksenych, Valentyn; Zusinaite, Eva; Tenson, Tanel. (2022) Seven classes of antiviral agents. Cellular and Molecular Life Sciences (CMLS)
    Academic literature review
  • Nordbø, Svein Arne; Linh, Hoang; Krokstad, Sidsel; Kainov, Denis; Sagvik, Eli Oline. (2022) Rask eliminasjon av SARS-CoV-2 hos fullvaksinert pasient. www.tidsskriftet.no
    Short communication
  • Oksenych, Valentyn; Kainov, Denis. (2022) Broad-Spectrum Antivirals and Antiviral Drug Combinations. Viruses
    Editorial
  • Li, Pengfei; Li, Yunlong; Wang, Yijin; Liu, Jiaye; Lavrijsen, Marla; Li, Yang. (2022) Recapitulating hepatitis E virus-host interactions and facilitating antiviral drug discovery in human liver-derived organoids. Science Advances
    Academic article

2021

  • Ianevski, Aleksandr; Yao, Rouan; Zusinaite, Eva; Lysvand, Hilde; Oksenych, Valentyn; Tenson, Tanel. (2021) Active components of commonly prescribed medicines affect influenza a virus–host cell interaction: A pilot study. Viruses
    Academic article
  • Rabben, Hanne-Line; Andersen, Gøran Troseth; Olsen, Magnus Kringstad; Øverby, Anders; Ianevski, Aleksandr; Kainov, Denis. (2021) Neural signaling modulates metabolism of gastric cancer. iScience
    Academic article
  • White, Judith M.; Schiffer, Joshua T.; Bender Ignacio, Rachel A.; Xu, Shuang; Kainov, Denis; Ianevski, Aleksandr. (2021) Drug Combinations as a First Line of Defense against Coronaviruses and Other Emerging Viruses. mBio
    Academic literature review
  • Yao, Rouan; Ianevski, Aleksandr; Kainov, Denis. (2021) Safe-in-Man Broad Spectrum Antiviral Agents. Springer
    Academic chapter/article/Conference paper
  • Li, Yunlong; Miao, Zhijiang; Li, Pengfei; Zhang, Ruyi; Kainov, Denis; Ma, Zhongren. (2021) Ivermectin effectively inhibits hepatitis E virus replication, requiring the host nuclear transport protein importin α1. Archives of Virology
    Academic article
  • Ianevski, Aleksandr; Yao, Rouan; Zusinaite, Eva; Lello, Laura Sandra; Wang, Sainan; Jo, Eunji. (2021) Synergistic interferon-alpha-based combinations for treatment of sars-cov-2 and other viral infections. Viruses
    Academic article
  • Kainov, Denis; Oksenych, Valentyn. (2021) DNA Damage Response. Biomolecules
    Editorial
  • Meehyun, Ko; Chang, Soo Young; Byun, Soo Young; Ianevski, Aleksandr; Choi, Inhee; Pham Hung, Anne-Laure. (2021) Screening of FDA-Approved Drugs Using a MERS-CoV Clinical Isolate from South Korea Identifies Potential Therapeutic Options for COVID-19. Viruses
    Academic article
  • Yang, Jaewon; König, Alexander; Park, Soonju; Jo, Eunji; Sung, Pil Soo; Yoon, Seung Kew. (2021) A new high-content screening assay of the entire hepatitis B virus life cycle identifies novel antivirals. JHEP Reports
    Academic article
  • Ianevski, Aleksandr; Yao, Rouan; Lysvand, Hilde; Grødeland, Gunnveig; Legrand, Nicolas; Oksenych, Valentyn. (2021) Nafamostat–interferon-α combination suppresses sars-cov-2 infection in vitro and in vivo by cooperatively targeting host tmprss2. Viruses
    Academic article
  • Ladner, Jason T.; Henson, Sierra N.; Boyle, Annalee S.; Engelbrektson, Anna L.; Fink, Zane W.; Rahee, Fatima. (2021) Epitope-resolved profiling of the SARS-CoV-2 antibody response identifies cross-reactivity with endemic human coronaviruses. Cell Reports Medicine
    Academic article
  • Rabben, Hanne-Line; Andersen, Gøran Troseth; Ianevski, Aleksandr; Olsen, Magnus Kringstad; Kainov, Denis; Grønbech, Jon Erik. (2021) Computational Drug Repositioning and Experimental Validation of Ivermectin in Treatment of Gastric Cancer. Frontiers in Pharmacology
    Academic article
  • Oksenych, Valentyn; Kainov, Denis. (2021) DNA Damage Response. Biomolecules
    Editorial

2020

  • Li, Yunlong; Li, Pengfei; Li, Yang; Zhang, Ruyi; Yu, Peifa; Ma, Zhongren. (2020) Drug screening identified gemcitabine inhibiting hepatitis E virus by inducing interferon-like response via activation of STAT1 phosphorylation. Antiviral Research
    Academic article
  • Anderssen, Petter Inge; Ianevski, Aleksandr; Lysvand, Hilde; Vitkauskiene, Astra; Oksenych, Valentyn; Bjørås, Magnar. (2020) Discovery and development of safe-in-man broad-spectrum antiviral agents. International Journal of Infectious Diseases
    Academic literature review
  • Chen, Sunrui; Wang, Yining; Li, Pengfei; Yin, Yuebang; Bijvelds, Marcel J.; de Jonge, Hugo R.. (2020) Drug screening identifies gemcitabine inhibiting rotavirus through alteration of pyrimidine nucleotide synthesis pathway. Antiviral Research
    Academic article
  • Ianevski, Aleksandr; Yao, Rouan; Fenstad, Mona H.; Biza, Svetlana; Zusinaite, Eva; Reisberg, Tuuli. (2020) Potential Antiviral Options against SARS-CoV-2 Infection. Viruses. Viruses
    Academic article
  • Ianevski, Aleksandr; Yao, Rouan; Biza, Svetlana; Zusinaite, Eva; Mannik, Andres; Kivi, Gaily. (2020) Identification and Tracking of Antiviral Drug Combinations. Viruses
    Academic article
  • Ianevski, Aleksandr; Kulesskiy, Evgeny; Krpina, Klara; Lou, Guofeng; Aman, Yahyah; Bugai, Andrii. (2020) Chemical, Physical and Biological Triggers of Evolutionary Sonserved Bcl-xL-Mediated Apoptosis. Cancers
    Academic article

2019

  • Ianevski, Aleksandr; Anderssen, Petter Inge; Merits, Andres; Bjørås, Magnar; Kainov, Denis. (2019) Expanding the activity spectrum of antiviral agents. Drug Discovery Today
    Academic literature review
  • Ianevski, Aleksandr; Zusinaite, Eva; Shtaida, Nastassia; Kallio-Kokko, Hannimari; Valkonen, Mia; Kantele, Anu. (2019) Low temperature and low UV indexes correlated with peaks of influenza virus activity in Northern Europe during 2010-2018. Viruses
    Academic article
  • Anderssen, Petter Inge; Krpina, Klara; Ianevski, Aleksandr; Shtaida, Nastassia; Jo, Eunji; Yang, Jaewon. (2019) Novel antiviral activities of obatoclax, emetine, niclosamide, brequinar, and homoharringtonine. Viruses
    Academic article
  • Bösl, Korbinian; Ianevski, Aleksandr; Than, Thoa T.; Anderssen, Petter Inge; Kuivanen, Suvi; Teppor, Mona. (2019) Common nodes of virus-host interaction revealed through an integrated network analysis. Frontiers in Immunology
    Academic article

2018

  • Zusinaite, Eva; Ianevski, Aleksandr; Niukkanen, Diana; Poranen, Minna M.; Bjørås, Magnar; Afset, Jan Egil. (2018) A systems approach to study immuno- and neuro-modulatory properties of antiviral agents. Viruses
    Academic literature review
  • Loevenich, Simon; Ianevski, Aleksandr; Oitmaa, Eneli; Kainov, Denis; Anthonsen, Marit Walbye. (2018) Single passage of human metapneumovirus in LLCMK2 cells does not affect viral protein-coding capacity. Microbiology Resource Announcements (MRA)
    Short communication
  • Ianevski, Aleksandr; Zusinaite, Eva; Kuivanen, Suvi; Strand, Mårten; Lysvand, Hilde; Teppor, Mona. (2018) Novel activities of safe-in-human broad-spectrum antiviral agents. Antiviral Research
    Academic article

2017

  • Bulanova, Daria; Ianevski, Aleksandr; Bugai, Andrii; Akimov, Yevhen; Kuivanen, Suvi; Paavilainen, Henrik. (2017) Antiviral properties of chemical inhibitors of cellular anti-apoptotic Bcl-2 proteins. Viruses
    Academic article
  • Gaelings, Lana; Söderholm, Sandra; Bugai, Andrii; Fu, Yu; Nandania, Jatin; Schepens, Bert. (2017) Regulation of kynurenine biosynthesis during influenza virus infection. The FEBS Journal
    Academic article
  • Shim, Jung Min; Kim, Jinhee; Tenson, Tanel; Min, Ji-Young; Kainov, Denis. (2017) Influenza virus infection, interferon response, viral counter-response, and apoptosis. Viruses
    Academic literature review

2016

  • Nyman, Tuula Anneli; Söderholm, Sandra; Kainov, Denis; Ohman, Tiina; Denisova, Oxana V.; Schepens, Bert. (2016) Phosphoproteomics to Characterize Host Response During Influenza A Virus Infection of Human Macrophages. Molecular & Cellular Proteomics
    Academic article
  • Anastasina, Maria; Le May, Nicolas; Bugai, Andrii; Fu, Yu; Söderholm, Sandra; Gaelings, Lana. (2016) Influenza virus NS1 protein binds cellular DNA to block transcription of antiviral genes. Biochimica et Biophysica Acta. Gene Regulatory Mechanisms
    Academic article
  • Söderholm, Sandra; Kainov, Denis E.; Öhman, Tiina; Denisova, Oxana V.; Schepens, Bert; Kulesskiy, Evgeny. (2016) Phosphoproteomics to characterize host response during influenza a virus infection of human macrophages. Molecular & Cellular Proteomics
    Academic article

Journal publications

  • Ravlo, Erlend; Ianevski, Aleksandr; Schjølberg, Jørn-Ove; Solvang, Vanessa; Dumaru, Rabina; Lysvand, Hilde. (2025) Synergistic combination of orally available safe-in-man pleconaril, AG7404, and mindeudesivir inhibits enterovirus infections in human cell and organoid cultures. Cellular and Molecular Life Sciences (CMLS)
    Academic article
  • Kainov, Denis; Ravlo, Erlend; Ianevski, Aleksandr. (2025) Seeking innovative concepts in development of antiviral drug combinations. Antiviral Research
    Academic literature review
  • Andersen, Gøran Troseth; Ianevski, Aleksandr; Resell, Mathilde Victoria; Pojskic, Naris; Rabben, Hanne-Line; Geithus, Synne. (2024) Multi-bioinformatics revealed potential biomarkers and repurposed drugs for gastric adenocarcinoma-related gastric intestinal metaplasia. npj Systems Biology and Applications
    Academic article
  • Halabitska, Iryna; Petakh, Pavlo; Kamyshna, Iryna; Oksenych, Valentyn; Kainov, Denis; Kamyshnyi, Oleksandr. (2024) The interplay of gut microbiota, obesity, and depression: insights and interventions. Cellular and Molecular Life Sciences (CMLS)
    Academic literature review
  • Ianevski, Aleksandr; Frøysa, Irene Trøen; Lysvand, Hilde; Calitz, Carlemi; Smura, Teemu; Nilsen, Hans-Johnny. (2024) The combination of pleconaril, rupintrivir, and remdesivir efficiently inhibits enterovirus infections in vitro, delaying the development of drug-resistant virus variants. Antiviral Research
    Academic article
  • Ravlo, Erlend; Ianevski, Aleksandr; Starheim, Eirin Johannessen; Wang, Wei; Ji, Ping; Lysvand, Hilde. (2023) Boosted production of antibodies that neutralized different SARS-CoV-2 variants in a COVID-19 convalescent following messenger RNA vaccination - a case study. International Journal of Infectious Diseases
    Article in business/trade/industry journal
  • Wang, Yining; Li, Pengfei; Xu, Lei; de Vries, Annemarie C.; Rottier, Robbert J.; Wang, Wenshi. (2023) Combating pan-coronavirus infection by indomethacin through simultaneously inhibiting viral replication and inflammatory response. iScience
    Academic article
  • Hermet, Paule; Delache, Benoît; Herate, Cecile; Wolf, Esther; Kivi, Gaily; Juronen, Erkki. (2023) Broadly neutralizing humanized SARS-CoV-2 antibody binds to a conserved epitope on Spike and provides antiviral protection through inhalation-based delivery in nonhuman primates. PLoS Pathogens
    Academic article
  • Kamyshnyi, Aleksandr; Koval, Halyna; Kobevko, Olha; Buchynskyi, Mykhailo; Oksenych, Valentyn; Kaynov, Denis. (2023) Therapeutic Effectiveness of Interferon-α2b against COVID-19 with Community-Acquired Pneumonia: The Ukrainian Experience. International Journal of Molecular Sciences
    Academic article
  • Petakh, Pavlo; Kamyshna, Iryna; Oksenych, Valentyn; Kainov, Denis; Kamyshnyi, Aleksandr. (2023) Metformin Therapy Changes Gut Microbiota Alpha-Diversity in COVID-19 Patients with Type 2 Diabetes: The Role of SARS-CoV-2 Variants and Antibiotic Treatment. Pharmaceuticals
    Academic article
  • Benjakul, Sopisa; Anthi, Aina Karen; Kolderup, Heidi Anette; Vaysburd, Marina; Lode, Heidrun Elisabeth; Mallery, D. (2023) A pan-SARS-CoV-2-specific soluble angiotensin-converting enzyme 2-albumin fusion engineered for enhanced plasma half-life and needle-free mucosal delivery. PNAS Nexus
    Academic article
  • Pinto, Sneha M.; Subbannayya, Yashwanth; Kim, Hera; Hagen, Lars; Górna, Maria W; Nieminen, Anni I.. (2022) Multi-OMICs landscape of SARS-CoV-2-induced host responses in human lung epithelial cells. iScience
    Academic article
  • Ianevski, Aleksandr; Yao, Rouan; Simonsen, Ronja Meyer; Myhre, Vegard; Ravlo, Erlend; Kaynova, Gerda D.. (2022) Mono- and combinational drug therapies for global viral pandemic preparedness. iScience
    Academic literature review
  • Ravlo, Erlend; Evensen, Lasse; Sanson, Gorm; Hildonen, Siri; Ianevski, Aleksandr; Skjervold, Per Olav. (2022) Antiviral Immunoglobulins of Chicken Egg Yolk for Potential Prevention of SARS-CoV-2 Infection. Viruses
    Academic article
  • Ianevski, Aleksandr; Simonsen, Ronja Meyer; Myhre, Vegard; Tenson, Tanel; Oksenych, Valentyn; Bjørås, Magnar. (2022) DrugVirus.info 2.0: an integrative data portal for broad-spectrum antivirals (BSA) and BSA-containing drug combinations (BCCs). Nucleic Acids Research (NAR)
    Academic article
  • Kainov, Denis; Oksenych, Valentyn. (2022) Broad-Spectrum Antivirals and Antiviral Combinations: An Editorial Update. Viruses
    Editorial
  • Ianevski, Aleksandr; Zusinaite, Eva; Tenson, Tanel; Oksenych, Valentyn; Wang, Wei; Afset, Jan Egil. (2022) Novel Synergistic Anti-Enteroviral Drug Combinations. Viruses
    Academic article
  • Ianevski, Aleksandr; Ahmad, Shahzaib; Anunnitipat, Kraipit; Oksenych, Valentyn; Zusinaite, Eva; Tenson, Tanel. (2022) Seven classes of antiviral agents. Cellular and Molecular Life Sciences (CMLS)
    Academic literature review
  • Nordbø, Svein Arne; Linh, Hoang; Krokstad, Sidsel; Kainov, Denis; Sagvik, Eli Oline. (2022) Rask eliminasjon av SARS-CoV-2 hos fullvaksinert pasient. www.tidsskriftet.no
    Short communication
  • Oksenych, Valentyn; Kainov, Denis. (2022) Broad-Spectrum Antivirals and Antiviral Drug Combinations. Viruses
    Editorial
  • Li, Pengfei; Li, Yunlong; Wang, Yijin; Liu, Jiaye; Lavrijsen, Marla; Li, Yang. (2022) Recapitulating hepatitis E virus-host interactions and facilitating antiviral drug discovery in human liver-derived organoids. Science Advances
    Academic article
  • Ianevski, Aleksandr; Yao, Rouan; Zusinaite, Eva; Lysvand, Hilde; Oksenych, Valentyn; Tenson, Tanel. (2021) Active components of commonly prescribed medicines affect influenza a virus–host cell interaction: A pilot study. Viruses
    Academic article
  • Rabben, Hanne-Line; Andersen, Gøran Troseth; Olsen, Magnus Kringstad; Øverby, Anders; Ianevski, Aleksandr; Kainov, Denis. (2021) Neural signaling modulates metabolism of gastric cancer. iScience
    Academic article
  • White, Judith M.; Schiffer, Joshua T.; Bender Ignacio, Rachel A.; Xu, Shuang; Kainov, Denis; Ianevski, Aleksandr. (2021) Drug Combinations as a First Line of Defense against Coronaviruses and Other Emerging Viruses. mBio
    Academic literature review
  • Li, Yunlong; Miao, Zhijiang; Li, Pengfei; Zhang, Ruyi; Kainov, Denis; Ma, Zhongren. (2021) Ivermectin effectively inhibits hepatitis E virus replication, requiring the host nuclear transport protein importin α1. Archives of Virology
    Academic article
  • Ianevski, Aleksandr; Yao, Rouan; Zusinaite, Eva; Lello, Laura Sandra; Wang, Sainan; Jo, Eunji. (2021) Synergistic interferon-alpha-based combinations for treatment of sars-cov-2 and other viral infections. Viruses
    Academic article
  • Kainov, Denis; Oksenych, Valentyn. (2021) DNA Damage Response. Biomolecules
    Editorial
  • Meehyun, Ko; Chang, Soo Young; Byun, Soo Young; Ianevski, Aleksandr; Choi, Inhee; Pham Hung, Anne-Laure. (2021) Screening of FDA-Approved Drugs Using a MERS-CoV Clinical Isolate from South Korea Identifies Potential Therapeutic Options for COVID-19. Viruses
    Academic article
  • Yang, Jaewon; König, Alexander; Park, Soonju; Jo, Eunji; Sung, Pil Soo; Yoon, Seung Kew. (2021) A new high-content screening assay of the entire hepatitis B virus life cycle identifies novel antivirals. JHEP Reports
    Academic article
  • Ianevski, Aleksandr; Yao, Rouan; Lysvand, Hilde; Grødeland, Gunnveig; Legrand, Nicolas; Oksenych, Valentyn. (2021) Nafamostat–interferon-α combination suppresses sars-cov-2 infection in vitro and in vivo by cooperatively targeting host tmprss2. Viruses
    Academic article
  • Ladner, Jason T.; Henson, Sierra N.; Boyle, Annalee S.; Engelbrektson, Anna L.; Fink, Zane W.; Rahee, Fatima. (2021) Epitope-resolved profiling of the SARS-CoV-2 antibody response identifies cross-reactivity with endemic human coronaviruses. Cell Reports Medicine
    Academic article
  • Rabben, Hanne-Line; Andersen, Gøran Troseth; Ianevski, Aleksandr; Olsen, Magnus Kringstad; Kainov, Denis; Grønbech, Jon Erik. (2021) Computational Drug Repositioning and Experimental Validation of Ivermectin in Treatment of Gastric Cancer. Frontiers in Pharmacology
    Academic article
  • Oksenych, Valentyn; Kainov, Denis. (2021) DNA Damage Response. Biomolecules
    Editorial
  • Li, Yunlong; Li, Pengfei; Li, Yang; Zhang, Ruyi; Yu, Peifa; Ma, Zhongren. (2020) Drug screening identified gemcitabine inhibiting hepatitis E virus by inducing interferon-like response via activation of STAT1 phosphorylation. Antiviral Research
    Academic article
  • Anderssen, Petter Inge; Ianevski, Aleksandr; Lysvand, Hilde; Vitkauskiene, Astra; Oksenych, Valentyn; Bjørås, Magnar. (2020) Discovery and development of safe-in-man broad-spectrum antiviral agents. International Journal of Infectious Diseases
    Academic literature review
  • Chen, Sunrui; Wang, Yining; Li, Pengfei; Yin, Yuebang; Bijvelds, Marcel J.; de Jonge, Hugo R.. (2020) Drug screening identifies gemcitabine inhibiting rotavirus through alteration of pyrimidine nucleotide synthesis pathway. Antiviral Research
    Academic article
  • Ianevski, Aleksandr; Yao, Rouan; Fenstad, Mona H.; Biza, Svetlana; Zusinaite, Eva; Reisberg, Tuuli. (2020) Potential Antiviral Options against SARS-CoV-2 Infection. Viruses. Viruses
    Academic article
  • Ianevski, Aleksandr; Yao, Rouan; Biza, Svetlana; Zusinaite, Eva; Mannik, Andres; Kivi, Gaily. (2020) Identification and Tracking of Antiviral Drug Combinations. Viruses
    Academic article
  • Ianevski, Aleksandr; Kulesskiy, Evgeny; Krpina, Klara; Lou, Guofeng; Aman, Yahyah; Bugai, Andrii. (2020) Chemical, Physical and Biological Triggers of Evolutionary Sonserved Bcl-xL-Mediated Apoptosis. Cancers
    Academic article
  • Ianevski, Aleksandr; Anderssen, Petter Inge; Merits, Andres; Bjørås, Magnar; Kainov, Denis. (2019) Expanding the activity spectrum of antiviral agents. Drug Discovery Today
    Academic literature review
  • Ianevski, Aleksandr; Zusinaite, Eva; Shtaida, Nastassia; Kallio-Kokko, Hannimari; Valkonen, Mia; Kantele, Anu. (2019) Low temperature and low UV indexes correlated with peaks of influenza virus activity in Northern Europe during 2010-2018. Viruses
    Academic article
  • Anderssen, Petter Inge; Krpina, Klara; Ianevski, Aleksandr; Shtaida, Nastassia; Jo, Eunji; Yang, Jaewon. (2019) Novel antiviral activities of obatoclax, emetine, niclosamide, brequinar, and homoharringtonine. Viruses
    Academic article
  • Bösl, Korbinian; Ianevski, Aleksandr; Than, Thoa T.; Anderssen, Petter Inge; Kuivanen, Suvi; Teppor, Mona. (2019) Common nodes of virus-host interaction revealed through an integrated network analysis. Frontiers in Immunology
    Academic article
  • Zusinaite, Eva; Ianevski, Aleksandr; Niukkanen, Diana; Poranen, Minna M.; Bjørås, Magnar; Afset, Jan Egil. (2018) A systems approach to study immuno- and neuro-modulatory properties of antiviral agents. Viruses
    Academic literature review
  • Loevenich, Simon; Ianevski, Aleksandr; Oitmaa, Eneli; Kainov, Denis; Anthonsen, Marit Walbye. (2018) Single passage of human metapneumovirus in LLCMK2 cells does not affect viral protein-coding capacity. Microbiology Resource Announcements (MRA)
    Short communication
  • Ianevski, Aleksandr; Zusinaite, Eva; Kuivanen, Suvi; Strand, Mårten; Lysvand, Hilde; Teppor, Mona. (2018) Novel activities of safe-in-human broad-spectrum antiviral agents. Antiviral Research
    Academic article
  • Bulanova, Daria; Ianevski, Aleksandr; Bugai, Andrii; Akimov, Yevhen; Kuivanen, Suvi; Paavilainen, Henrik. (2017) Antiviral properties of chemical inhibitors of cellular anti-apoptotic Bcl-2 proteins. Viruses
    Academic article
  • Gaelings, Lana; Söderholm, Sandra; Bugai, Andrii; Fu, Yu; Nandania, Jatin; Schepens, Bert. (2017) Regulation of kynurenine biosynthesis during influenza virus infection. The FEBS Journal
    Academic article
  • Shim, Jung Min; Kim, Jinhee; Tenson, Tanel; Min, Ji-Young; Kainov, Denis. (2017) Influenza virus infection, interferon response, viral counter-response, and apoptosis. Viruses
    Academic literature review
  • Nyman, Tuula Anneli; Söderholm, Sandra; Kainov, Denis; Ohman, Tiina; Denisova, Oxana V.; Schepens, Bert. (2016) Phosphoproteomics to Characterize Host Response During Influenza A Virus Infection of Human Macrophages. Molecular & Cellular Proteomics
    Academic article
  • Anastasina, Maria; Le May, Nicolas; Bugai, Andrii; Fu, Yu; Söderholm, Sandra; Gaelings, Lana. (2016) Influenza virus NS1 protein binds cellular DNA to block transcription of antiviral genes. Biochimica et Biophysica Acta. Gene Regulatory Mechanisms
    Academic article
  • Söderholm, Sandra; Kainov, Denis E.; Öhman, Tiina; Denisova, Oxana V.; Schepens, Bert; Kulesskiy, Evgeny. (2016) Phosphoproteomics to characterize host response during influenza a virus infection of human macrophages. Molecular & Cellular Proteomics
    Academic article

Part of book/report

  • Yao, Rouan; Ianevski, Aleksandr; Kainov, Denis. (2021) Safe-in-Man Broad Spectrum Antiviral Agents. Springer
    Academic chapter/article/Conference paper

Teaching

Courses

  • MFEL4852 - Experts in Teamwork - Science and fiction

MOL3020 Virologi

MFEL4852 Eksperter i team - Vitenskap og fiksjon

 

 

Supervision

Currently supervising one Master Student.

Outreach

The enormous but unknown curative power of old drugs

A legislative reform being prepared by the European Union plans to promote the use of already approved drugs to treat other illnesses. Doing so will speed up the approval of treatments and save on research costs

Why you should be vaccinated even if you have had COVID-19

Convalescent plasma therapy research provides an unanticipated insight into how the body fights COVID-19 variants

Rapid passive immunity via inhalation - a novel approach against respiratory pathogens

Broadly neutralizing humanized SARS-CoV-2 antibody binds to a conserved epitope on Spike and provides antiviral protection through inhalation-based delivery in non-human primates

A long-acting biologic with transmucosal transport properties that arrest SARS-CoV-2 virus variants

A pan-SARS-CoV-2 specific soluble ACE2-albumin fusion engineered for enhanced plasma half-life and needle-free mucosal delivery

New drug screening tool to fight the next pandemic

A database with existing active antiviral substances that have gone through initial pharmaceutical testing could jumpstart the development of new treatments when the next pandemic comes

Common medications alter flu virus activity

Some medications amplify the effects of the virus, while others reduce it

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