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Eirik Sundby

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Eirik Sundby

Professor
Department of Materials Science and Engineering
Faculty of Natural Sciences

eirik.sundby@ntnu.no
+4773559645 Teknologibygget, Kalvskinnet
Publications Teaching Outreach

Publications

  • Chronological
  • By category
  • All publications registered in NVA

2025

  • Cherukupalli, Srinivasulu; Degenhart, Carsten; Habenberger, Peter; Unger, Anke; Eickhoff, Jan; Hoff, Bård Helge; Sundby, Eirik. (2025) Design and Synthesis of Pyridine-Based Pyrrolo[2,3-d]pyrimidine Analogs as CSF1R Inhibitors: Molecular Hybridization and Scaffold Hopping Approach. Pharmaceuticals
    Academic article
  • Cherukupalli, Srinivasulu; Eickhoff, Jan; Degenhart, Carsten; Habenberger, Peter; Unger, Anke; Hoff, Bård Helge; Sundby, Eirik. (2025) Evaluating Triazole-Substituted Pyrrolopyrimidines as CSF1R Inhibitors. Molecules
    Academic article
  • Kissova, Miroslava; Segarra, Judit Martinez; Iveland, Tobias Solli; Vestvik, Marthe; Ravlo, Erlend; Wang, Wei; Hagen, Lars; Liabakk, Nina-Beate; Camara Quilez, Maria; Barenys, Miquel Arano. (2025) RNaseH2 inhibition potentiates temozolomide response in patient derived glioblastoma cells. Scientific Reports
    Academic article
  • Olsen, Cecilie Elisabeth; Simonsen, Signe; Merugu, Srinivas Reddy; Eigner, Vaclav; Aachmann, Finn Lillelund; Kragelund, Birthe B.; Sundby, Eirik; Hoff, Bård Helge. (2025) Synthesis and evaluation of fluorinated tetrahydrocarbazoles as probes in NMR based binding assay of the E. coli β sliding clamp. Bioorganic & Medicinal Chemistry
    Academic article
  • Cherukupalli, Srinivasulu; Karlsen, Morten; Hoff, Bård Helge; Sundby, Eirik. (2025) Design and Synthesis of a 18F-Radiolabeled Pyrrolo[2,3-d]pyrimidine Ligand as a CSF1R Receptor PET Imaging Agent. Journal of labelled compounds & radiopharmaceuticals
    Academic article

2024

  • Elumalai, Vijayaragavan; Eigner, Václav; Visnes, Torkild; Sundby, Eirik; Hoff, Bård Helge. (2024) Improved Synthetic Methodology, Substrate Scope and X-ray Crystal Structure for N, N’-disubstituted Guanidines. ChemistrySelect
    Academic article
  • Merugu, Srinivas Reddy; Selmer-Olsen, Sigrid M.E.; Johansen, Camilla; Sundby, Eirik; Hoff, Bård Helge. (2024) Synthetic Routes to 2-aryl-1H-pyrrolo[2,3-b]pyridin-4-amines: Cross-Coupling and Challenges in SEM-Deprotection. Molecules
    Academic article
  • Elumalai, Vijayaragavan; Eigner, Václav; Janjua, Nicholas Alexander; Åstrand, Per-Olof Harald; Visnes, Torkild; Sundby, Eirik; Hoff, Bård Helge. (2024) X-ray Structure of Eleven New N,N′-Substituted Guanidines: Effect of Substituents on Tautomer Structure in the Solid State. Crystals
    Academic article
  • Bjørnstad, Frithjof Andreas; Havik, Simen; Aarhus, Thomas Ihle; Mahdi, Iktedar; Unger, Anke; Habenberger, Peter; Degenhart, Carsten; Eickhoff, Jan; Klebl, Bert M.; Sundby, Eirik. (2024) Pyrrolopyrimidine based CSF1R inhibitors: Attempted departure from Flatland. European Journal of Medicinal Chemistry
    Academic article
  • Østby, Lene; Sundby, Eirik; Jakobsen, Anita Nordeng. (2024) Authentic Hands-On Learning Approaches for Bulky Student Cohorts in General Chemistry Laboratory Using Case and Peer Assessment. Journal of Chemical Education
    Academic article

2023

  • Bjørnstad, Frithjof Andreas; Sundby, Eirik; Hoff, Bård Helge. (2023) Directed Lithiation of Protected 4-Chloropyrrolopyrimidine: Addition to Aldehydes and Ketones Aided by Bis(2-dimethylaminoethyl)ether. Molecules
    Academic article
  • Singleton, Amanda Holstad; Bergum, Olaug Elisabeth Torheim; Søgaard, Caroline Krogh; Røst, Lisa M.; Olsen, Cecilie Elisabeth; Blindheim, Fredrik Heen; Ræder, Synnøve Brandt; Bjørnstad, Frithjof Andreas; Sundby, Eirik; Hoff, Bård Helge. (2023) Activation of multiple stress responses in Staphylococcus aureus substantially lowers the minimal inhibitory concentration when combining two novel antibiotic drug candidates. Frontiers in Microbiology
    Academic article
  • Aarhus, Thomas Ihle; Bjørnstad, Frithjof Andreas; Wolowczyk, Camilla Izabel; Larsen, Kristin Uhlving; Rognstad, Line; Leithaug, Trygve; Unger, Anke; Habenberger, Peter; Wolf, Alexander; Bjørkøy, Geir. (2023) Synthesis and Development of Highly Selective Pyrrolo[2,3-d]pyrimidine CSF1R Inhibitors Targeting the Autoinhibited Form. Journal of Medicinal Chemistry
    Academic article
  • Aarhus, Thomas Ihle; Teksum, Vilde; Unger, Anke; Habenberger, Peter; Wolf, Alexander; Eickhoff, Jan; Klebl, Bert; Wolowczyk, Camilla Izabel; Bjørkøy, Geir; Sundby, Eirik. (2023) Negishi Cross-Coupling in the Preparation of Benzyl Substituted Pyrrolo[2,3-d]pyrimidine Based CSF1R Inhibitors. European Journal of Organic Chemistry
    Academic article
  • Aarhus, Thomas Ihle; Eickhoff, Jan; Klebl, Bert; Unger, Anke; Boros, Johanna; Choidas, Axel; Zischinsky, Mia-Lisa; Wolowczyk, Camilla Izabel; Bjørkøy, Geir; Sundby, Eirik. (2023) A highly selective purine-based inhibitor of CSF1R potently inhibits osteoclast differentiation. European Journal of Medicinal Chemistry
    Academic article

2022

  • Olsen, Cecilie Elisabeth; Blindheim, Fredrik Heen; Søgaard, Caroline Krogh; Røst, Lisa M.; Singleton, Amanda; Bergum, Olaug Elisabeth Torheim; Bruheim, Per; Otterlei, Marit; Sundby, Eirik; Hoff, Bård Helge. (2022) Halogenated Pyrrolopyrimidines with Low MIC on Staphylococcus aureus and Synergistic Effects with an Antimicrobial Peptide. Antibiotics
    Academic article

2021

  • El-Behairy, Mohammed Farrag; Hassan, Rasha M.; Sundby, Eirik. (2021) Enantioselective chromatographic separation and lipase catalyzed asymmetric resolution of biologically important chiral amines. Separations
    Academic article
  • Blindheim, Fredrik Heen; Thoresen Malme, Ane; Dalhus, Bjørn; Sundby, Eirik; Hoff, Bård Helge. (2021) Synthesis and Evaluation of Fused Pyrimidines as E. coli Thymidylate Monophosphate Kinase Inhibitors. ChemistrySelect
    Academic article
  • Guttormsen, Yngve; Moldes-Anaya, Angel; Fjellaksel, Richard; Oteiza, Ana; Martin-Armas, Montserrat; Lindemann, Marcel; Bihler, Julia; Hoff, Bård Helge; Jakobsen, Steen; Sundby, Eirik. (2021) Development of a carbon-11 labeled thienopyrimidine based radioligand for EGFR-tyrosine-kinase-inhibitor (TKI) specific PET imaging of glioblastoma. Journal of Nuclear Medicine
    Conference abstract
  • Guttormsen, Yngve; Kranz, Mathias; Fjellaksel, Richard; Martin-Armas, Montserrat; Oteiza, Ana; Bihler, Julia; Lindemann, Marcel; Hoff, Bård Helge; Jakobsen, Steen; Sundby, Eirik. (2021) SP-015 - Preliminary evaluation of a novel carbon-11 labeled brain-penetrant EGFR-TKI radiotracer for brain cancer imaging. Nuclear Medicine and Biology
    Conference abstract
  • Blindheim, Fredrik Heen; Olsen, Cecilie Elisabeth; Søgaard, Caroline Krogh; Otterlei, Marit; Sundby, Eirik; Hoff, Bård Helge. (2021) Synthetic Strategies towards Imidazopyridinones and 7-Azaoxindoles and their Evaluation as Antibacterial Agents. European Journal of Organic Chemistry
    Academic article

2020

  • Sundby, Eirik; Haugen, Ingrid Naterstad. (2020) Comparison of Students' Perceived Learning in Two Similar Lab Courses with Different Teaching Staffs. Universal Journal of Educational Research
    Academic article

2019

  • Reiersølmoen, Ann Christin; Aarhus, Thomas Ihle; Eckelt, Sarah; Nørsett, Kristin Gabestad; Sundby, Eirik; Hoff, Bård Helge. (2019) Potent and selective EGFR inhibitors based on 5-aryl-7H-pyrrolopyrimidin-4-amines. Bioorganic chemistry (Print)
    Academic article

2018

  • Reiersølmoen, Ann Christin; Han, Jin; Sundby, Eirik; Hoff, Bård Helge. (2018) Identification of fused pyrimidines as interleukin 17 secretion inhibitors. European Journal of Medicinal Chemistry
    Academic article

2017

  • Petrovic, Voin; Olaisen, Camilla; Sharma, Animesh; Nepal, Anala; Bugge, Steffen; Sundby, Eirik; Hoff, Bård Helge; Slupphaug, Geir; Otterlei, Marit. (2017) Changes in cellular signaling proteins in extracts from A549, H460, and U2OS cells treated with cisplatin or docetaxel. Data in Brief
    Academic article
  • Hoff, Bård Helge; Sundby, Eirik. (2017) Is literature data useful for identifying enzyme catalysts for new substrates? A case study on reduction of 1-aryl-2-alkanoates. Bioorganic chemistry (Print)
    Academic article
  • Petrovic, Voin; Olaisen, Camilla; Sharma, Animesh; Nepal, Anala; Bugge, Steffen; Sundby, Eirik; Hoff, Bård Helge; Slupphaug, Geir; Otterlei, Marit. (2017) On-column trypsinization allows for re-use of matrix in modified multiplexed inhibitor beads assay. Analytical Biochemistry
    Academic article
  • Willumsen, Fredrik Bysting; Bugge, Steffen; Sundby, Eirik; Hoff, Bård Helge. (2017) Investigation of Heck coupling on 6-bromo[2,3-d]thienopyrimidines for construction of new EGFR inhibitor lead structures. RSC Advances
    Academic article

2016

  • Bugge, Steffen; Buene, Audun Formo; Jurisch-Yaksi, Nathalie; Moen, Ingri Ullestad; Skjønsfjell, Ellen Martine; Sundby, Eirik; Hoff, Bård Helge. (2016) Extended structure-activity study of thienopyrimidine-based EGFR inhibitors with evaluation of drug-like properties. European Journal of Medicinal Chemistry
    Academic article
  • Han, Jin; Henriksen, Silje; Nørsett, Kristin Gabestad; Sundby, Eirik; Hoff, Bård Helge. (2016) Balancing potency, metabolic stability and permeability in pyrrolopyrimidine-based EGFR inhibitors. European Journal of Medicinal Chemistry
    Academic article
  • El-Behairy, Mohammed Farrag; Sundby, Eirik. (2016) One-step lipase-catalysed preparation of eslicarbazepine. RSC Advances
    Academic article
  • Han, Jin; Kaspersen, Svein Jacob; Nervik, Sondre; Nørsett, Kristin; Sundby, Eirik; Hoff, Bård Helge. (2016) Chiral 6-aryl-furo[2,3-d]pyrimidin-4-amines as EGFR inhibitors. European Journal of Medicinal Chemistry
    Academic article

2015

  • Bugge, Steffen; Moen, Ingri Ullestad; Sylte, Kent-Ove Kragseth; Sundby, Eirik; Hoff, Bård Helge. (2015) Truncated structures used in search for new lead compounds and in a retrospective analysis of thienopyrimidine-based EGFR inhibitors. European Journal of Medicinal Chemistry
    Academic article
  • Sundby, Eirik; Han, Jin; Kaspersen, Svein Jacob; Hoff, Bård Helge. (2015) In vitro baselining of new pyrrolopyrimidine EGFR-TK inhibitors with Erlotinib. European Journal of Pharmaceutical Sciences
    Academic article

2014

  • Bugge, Steffen; Skjønsfjell, Ellen Martine; Willumsen, Fredrik Bysting; Sundby, Eirik; Hoff, Bård Helge. (2014) Improved and Scalable Preparation of 6-Bromo-4-Chlorothieno[2,3-d]Pyrimidine. Chemistry of Heterocyclic Compounds
    Academic article
  • Bugge, Steffen; Kaspersen, Svein Jacob; Larsen, Synne; Nonstad, Unni; Bjørkøy, Geir; Sundby, Eirik; Hoff, Bård Helge. (2014) Structure-activity study leading to identification of a highly active thienopyrimidine based EGFR inhibitor. European Journal of Medicinal Chemistry
    Academic article
  • Kaspersen, Svein Jacob; Han, Jin; Nørsett, Kristin; Rydså, Line; Kjøbli, Eli; Bugge, Steffen; Bjørkøy, Geir; Sundby, Eirik; Hoff, Bård Helge. (2014) Identification of new 4-N-substituted 6-aryl-7H-pyrrolo[2,3-d]pyrimidine-4- amines as highly potent EGFR-TK inhibitors with Src-family activity. European Journal of Pharmaceutical Sciences
    Academic article

2013

  • Thvedt, Thor Håkon Krane; Kaasa, Kristin; Sundby, Eirik; Charnock, Colin; Hoff, Bård Helge. (2013) Chiral N-benzyl-N-methyl-1-(naphthalen-1-yl)ethanamines and their in vitro antifungal activity against Cryptococcus neoformans, Trichophyton mentagrophytes and Trichophyton rubrum. European Journal of Medicinal Chemistry
    Academic article
  • Ali, Mohammed Farrag Mohammed; Sundby, Eirik. (2013) Synthesis of the antiepileptic (R)-Stiripentol by a combination of lipase catalyzed resolution and alkene metathesis. Tetrahedron: asymmetry
    Academic article
  • Hoff, Bård Helge; Sundby, Eirik. (2013) Preparation of pharmaceutical important fluorinated 1-arylethanols using isolated enzymes. Bioorganic chemistry (Print)
    Academic literature review
  • Han, Jin; Sundby, Eirik; Hoff, Bård Helge. (2013) Solvent selection in synthesis of 4-(1-arylfluoroethoxy)quinazolines and thienopyrimidines. Journal of fluorine chemistry
    Academic article

2012

  • Jacobsen, Elisabeth Egholm; Anthonsen, Thorleif; El-Behairy, Mohammed Farrag; Sundby, Eirik; Aboul-Enein, Mohamed Nabil; Attia, Mohamed Ibrahim; El-Azzouny, Aida Abd El-Sattar; Amin, Kamilia M.; Abdel-Rehim, Mohamed. (2012) Lipase Catalysed Kinetic Resolution of Stiripentol. International Journal of Chemistry
    Academic article
  • Bugge, Steffen; Kaspersen, Svein Jacob; Sundby, Eirik; Hoff, Bård Helge. (2012) Route selection in the synthesis of C-4 and C-6 substituted thienopyrimidines. Tetrahedron
    Academic article
  • Kaspersen, Svein Jacob; Sundby, Eirik; Charnock, Colin; Hoff, Bård Helge. (2012) Activity of 6-aryl-pyrrolo[2,3-d]pyrimidine-4-amines to Tetrahymena. Bioorganic chemistry (Print)
    Academic article
  • Esmurziev, Aslan; Reimers, Arne; Andreassen, Trygve; Simic, Nebojsa; Sundby, Eirik; Hoff, Bård Helge. (2012) Benzoylated uronic Acid building blocks and synthesis of N-uronate conjugates of lamotrigine. Molecules
    Academic article

2011

  • Slungård, Sigrid Volden; Krakeli, Tor-Arne; Thvedt, Thor Håkon Krane; Fuglseth, Erik; Sundby, Eirik; Hoff, Bård Helge. (2011) Investigation into the enantioselection mechanism of ruthenium-arene-diamine transfer hydrogenation catalysts using fluorinated substrates. Tetrahedron
    Academic article
  • Reimers, Arne; Østby, Lene; Stuen, Ina; Sundby, Eirik. (2011) Expression of UDP-glucuronosyltransferase 1A4 in human placenta at term. European journal of drug metabolism and pharmacokinetics
    Academic article
  • Kaspersen, Svein Jacob; Sørum, Christopher; Willassen, Veronica; Fuglseth, Erik; Kjøbli, Eli; Bjørkøy, Geir; Sundby, Eirik; Hoff, Bård Helge. (2011) Synthesis and in vitro EGFR (ErbB1) tyrosine kinase inhibitory activity of 4-N-substituted 6-aryl-7H-pyrrolo[2,3-d]pyrimidine-4-amines. European Journal of Medicinal Chemistry
    Academic article
  • Thvedt, Thor Håkon Krane; Kristensen, Tor Erik Holt; Sundby, Eirik; Hansen, Tore; Hoff, Bård Helge. (2011) Enantioselectivity, swelling and stability of 4-hydroxyprolinol containing acrylic polymer beads in the asymmetric reduction of ketones. Tetrahedron: asymmetry
    Academic article

2010

  • Thvedt, Thor Håkon Krane; Fuglseth, Erik; Sundby, Eirik; Hoff, Bård Helge. (2010) Enantioenriched 1-aryl-2-fluoroethylamines. Efficient lipase-catalysed resolution and limitations to the Mitsunobu inversion protocol. Tetrahedron
    Academic article
  • Sørum, Christopher; Simic, Nebojsa; Sundby, Eirik; Hoff, Bård Helge. (2010) 1H,13C and 19F NMR data of N-substituted 6-(4-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amines in DMSO-d6. Magnetic Resonance in Chemistry
    Academic article
  • Esmurziev, Aslan; Simic, Nebojsa; Hoff, Bård Helge; Sundby, Eirik. (2010) Synthesis and Structure Elucidation of Benzoylated Deoxyfluoropyranosides. Journal of carbohydrate chemistry
    Academic article

2009

  • Esmurziev, Aslan; Sundby, Eirik; Hoff, Bård Helge. (2009) Regioselective C-6 Hydrolysis of Methyl O-Benzoyl-pyranosides Catalysed by Candida Rugosa Lipase. European Journal of Organic Chemistry
    Academic article
  • Esmurziev, Aslan; Simic, N.; Sundby, Eirik; Hoff, Bård Helge. (2009) H-1 and C-13 NMR data of methyl tetra-O-benzoyl-D-pyranosides in acetone-d(6). Magnetic Resonance in Chemistry
    Academic article
  • Fuglseth, Erik; Sundby, Eirik; Hoff, Bård Helge. (2009) Ruthenium-catalysed asymmetric transfer hydrogenation of para-substituted alpha-fluoroacetophenones. Journal of fluorine chemistry
    Academic article

2008

  • Fuglseth, Erik; Sundby, Eirik; Bruheim, Per; Hoff, Bård Helge. (2008) Asymmetric reduction using (R)-MeCBS and determination of absolute configuration of para-substituted 2-fluoroarylethanols. Tetrahedron: asymmetry
    Academic article
  • Sundby, Eirik; Frommholz, David. (2008) Conversion of Cod Liver Oil to Fatty Acid Methyl Esters Catalyzed by Various Lipases in a Solvent-free system. HiST
    Research report

2007

  • Sundby, Eirik. (2007) Lynkurs i organisk kjemi for ikke-kjemikere. KMT/AFT
    Working paper
  • Jørgensen, Kåre B.; Sundby, Eirik. (2007) The 21st International Symposium for Polycyclic Aromatic Compounds Om tjærestoffer i Trondheim. Kjemi
    Professional article
  • Sundby, Eirik. (2007) Polyfunksjonell navnsetting. KMT/AFT
    Working paper

2006

  • Østby, Lene; Sundby, Eirik; Krøkje, Åse. (2006) Evaluation of CYP1A protein induction, biotransformation capacity and DNA adduct formation in a rat hepatoma cell line (Fao), as biomarkers of organic contamination in environmental soil samples. Water, Air and Soil Pollution
    Academic article
  • Østby, Lene; Sundby, Eirik; Krøkje, Åse. (2006) Evaluation of CYP1A protein induction, biotransformation capacity and DNA adduct formation in a rat hepatoma cell line (FAO), as biomarkers of organic contamination in environmental soil samples. Water, Air and Soil Pollution
    Academic article

2004

  • Sundby, Eirik; Anthonsen, Thorleif; Perk, L; Aasen, Arne Jørgen; Hansen, TV. (2004) Synthesis of (+)-Goniothalamin and its Enantiomer by Combination of Lipase Catalyzed Resolution and Alkene Metathesis. Tetrahedron
    Academic article
  • Sundby, Eirik; Holt, Jarle; Vik, Anders; Anthonsen, Thorleif. (2004) Chemoenzymatic synthesis of (2S)- and (2R)-2-(1,3-dithian-2-ylmethyl)oxirane. European Journal of Organic Chemistry
    Academic article
  • Sundby, Eirik; Perk, Lars; Anthonsen, Thorleif; Aasen, Arne Jørgen; Hansen, Trond Vidar. (2004) Synthesis of (+)-goniothalamin and its enantiomer by combination of lipase catalyzed resolution and alkene metathesis. Tetrahedron
    Academic article
  • Sundby, Eirik; Holt, Jarle; Vik, Anders; Anthonsen, Thorleif. (2004) Chemoenzymatic synthesis of (2S)- and (2R)-2-(1,3-dithian-2-ylmethyl)oxirane. European Journal of Organic Chemistry
    Academic article

2003

  • Sundby, Eirik. (2003) Biological reductions and esterifications for the production of enantiopure secondary alcohols : chemo-enzymatic synthesis of chiral building blocks with sulphur-containing rings. Norges teknisk-naturvitenskapelige universitet
    Doctoral thesis
  • Sundby, Eirik; Zotti, Martha De; Anthonsen, Thorleif. (2003) The Enantioselectivity of Reduction of Ethyl 4-bromo-3-oxobutanoate catalyzed by Geotrichum candidum depends on the Cofactor. Journal of Molecular Catalysis B: Enzymatic
    Academic article

2002

  • Sundby, Eirik; Anthonsen, Thorleif; Andersen, Morten Myhre; Hoff, Bård Helge. (2002) Lipase catalysed resolution and microbial reduction for obtaining enantiopure 1-(2-thienyl)alkanols. ARKIVOC
    Academic article

1999

  • Anthonsen, Thorleif; Hoff, Bård Helge; Hofsløkken, Nini; Skattebøl, Lars; Sundby, Eirik. (1999) Synthesis of 1,3-dithianes and 1,3-dithiolanes. Baker´s yeast reduction and lipase-catalyzed resolution for synthesis of enantiopure derivatives. Acta Chemica Scandinavica
    Academic article
  • Anthonsen, Thorleif; DÁrrigo, P; Pedrocche-Fantoni, G; Secundo, F; Servi, Stefano; Sundby, Eirik. (1999) Phospholipid hydrolysis in organic solvents catalysed by immobilised Phospholipase C. Journal of Molecular Catalysis B: Enzymatic
    Academic article

1998

  • Sundby, Eirik; Azerad, Robert; Anthonsen, Thorleif. (1998) 2,2-Dimethyl-1,3-propanediol as protective group promotes microbial hydroxylation of cis bicyclo[3.3.0]octane-3,7-dione. Biotechnology Letters
    Academic article

Journal publications

  • Cherukupalli, Srinivasulu; Degenhart, Carsten; Habenberger, Peter; Unger, Anke; Eickhoff, Jan; Hoff, Bård Helge; Sundby, Eirik. (2025) Design and Synthesis of Pyridine-Based Pyrrolo[2,3-d]pyrimidine Analogs as CSF1R Inhibitors: Molecular Hybridization and Scaffold Hopping Approach. Pharmaceuticals
    Academic article
  • Cherukupalli, Srinivasulu; Eickhoff, Jan; Degenhart, Carsten; Habenberger, Peter; Unger, Anke; Hoff, Bård Helge; Sundby, Eirik. (2025) Evaluating Triazole-Substituted Pyrrolopyrimidines as CSF1R Inhibitors. Molecules
    Academic article
  • Kissova, Miroslava; Segarra, Judit Martinez; Iveland, Tobias Solli; Vestvik, Marthe; Ravlo, Erlend; Wang, Wei; Hagen, Lars; Liabakk, Nina-Beate; Camara Quilez, Maria; Barenys, Miquel Arano. (2025) RNaseH2 inhibition potentiates temozolomide response in patient derived glioblastoma cells. Scientific Reports
    Academic article
  • El-Behairy, Mohammed Farrag; Hassan, Rasha M.; Sundby, Eirik. (2021) Enantioselective chromatographic separation and lipase catalyzed asymmetric resolution of biologically important chiral amines. Separations
    Academic article
  • Reiersølmoen, Ann Christin; Han, Jin; Sundby, Eirik; Hoff, Bård Helge. (2018) Identification of fused pyrimidines as interleukin 17 secretion inhibitors. European Journal of Medicinal Chemistry
    Academic article
  • Bugge, Steffen; Buene, Audun Formo; Jurisch-Yaksi, Nathalie; Moen, Ingri Ullestad; Skjønsfjell, Ellen Martine; Sundby, Eirik; Hoff, Bård Helge. (2016) Extended structure-activity study of thienopyrimidine-based EGFR inhibitors with evaluation of drug-like properties. European Journal of Medicinal Chemistry
    Academic article
  • Østby, Lene; Sundby, Eirik; Krøkje, Åse. (2006) Evaluation of CYP1A protein induction, biotransformation capacity and DNA adduct formation in a rat hepatoma cell line (Fao), as biomarkers of organic contamination in environmental soil samples. Water, Air and Soil Pollution
    Academic article
  • Blindheim, Fredrik Heen; Thoresen Malme, Ane; Dalhus, Bjørn; Sundby, Eirik; Hoff, Bård Helge. (2021) Synthesis and Evaluation of Fused Pyrimidines as E. coli Thymidylate Monophosphate Kinase Inhibitors. ChemistrySelect
    Academic article
  • Bjørnstad, Frithjof Andreas; Sundby, Eirik; Hoff, Bård Helge. (2023) Directed Lithiation of Protected 4-Chloropyrrolopyrimidine: Addition to Aldehydes and Ketones Aided by Bis(2-dimethylaminoethyl)ether. Molecules
    Academic article
  • Jørgensen, Kåre B.; Sundby, Eirik. (2007) The 21st International Symposium for Polycyclic Aromatic Compounds Om tjærestoffer i Trondheim. Kjemi
    Professional article
  • Guttormsen, Yngve; Moldes-Anaya, Angel; Fjellaksel, Richard; Oteiza, Ana; Martin-Armas, Montserrat; Lindemann, Marcel; Bihler, Julia; Hoff, Bård Helge; Jakobsen, Steen; Sundby, Eirik. (2021) Development of a carbon-11 labeled thienopyrimidine based radioligand for EGFR-tyrosine-kinase-inhibitor (TKI) specific PET imaging of glioblastoma. Journal of Nuclear Medicine
    Conference abstract
  • Guttormsen, Yngve; Kranz, Mathias; Fjellaksel, Richard; Martin-Armas, Montserrat; Oteiza, Ana; Bihler, Julia; Lindemann, Marcel; Hoff, Bård Helge; Jakobsen, Steen; Sundby, Eirik. (2021) SP-015 - Preliminary evaluation of a novel carbon-11 labeled brain-penetrant EGFR-TKI radiotracer for brain cancer imaging. Nuclear Medicine and Biology
    Conference abstract
  • Han, Jin; Henriksen, Silje; Nørsett, Kristin Gabestad; Sundby, Eirik; Hoff, Bård Helge. (2016) Balancing potency, metabolic stability and permeability in pyrrolopyrimidine-based EGFR inhibitors. European Journal of Medicinal Chemistry
    Academic article
  • Singleton, Amanda Holstad; Bergum, Olaug Elisabeth Torheim; Søgaard, Caroline Krogh; Røst, Lisa M.; Olsen, Cecilie Elisabeth; Blindheim, Fredrik Heen; Ræder, Synnøve Brandt; Bjørnstad, Frithjof Andreas; Sundby, Eirik; Hoff, Bård Helge. (2023) Activation of multiple stress responses in Staphylococcus aureus substantially lowers the minimal inhibitory concentration when combining two novel antibiotic drug candidates. Frontiers in Microbiology
    Academic article
  • Thvedt, Thor Håkon Krane; Fuglseth, Erik; Sundby, Eirik; Hoff, Bård Helge. (2010) Enantioenriched 1-aryl-2-fluoroethylamines. Efficient lipase-catalysed resolution and limitations to the Mitsunobu inversion protocol. Tetrahedron
    Academic article
  • Petrovic, Voin; Olaisen, Camilla; Sharma, Animesh; Nepal, Anala; Bugge, Steffen; Sundby, Eirik; Hoff, Bård Helge; Slupphaug, Geir; Otterlei, Marit. (2017) Changes in cellular signaling proteins in extracts from A549, H460, and U2OS cells treated with cisplatin or docetaxel. Data in Brief
    Academic article
  • Olsen, Cecilie Elisabeth; Simonsen, Signe; Merugu, Srinivas Reddy; Eigner, Vaclav; Aachmann, Finn Lillelund; Kragelund, Birthe B.; Sundby, Eirik; Hoff, Bård Helge. (2025) Synthesis and evaluation of fluorinated tetrahydrocarbazoles as probes in NMR based binding assay of the E. coli β sliding clamp. Bioorganic & Medicinal Chemistry
    Academic article
  • Bugge, Steffen; Moen, Ingri Ullestad; Sylte, Kent-Ove Kragseth; Sundby, Eirik; Hoff, Bård Helge. (2015) Truncated structures used in search for new lead compounds and in a retrospective analysis of thienopyrimidine-based EGFR inhibitors. European Journal of Medicinal Chemistry
    Academic article
  • Elumalai, Vijayaragavan; Eigner, Václav; Visnes, Torkild; Sundby, Eirik; Hoff, Bård Helge. (2024) Improved Synthetic Methodology, Substrate Scope and X-ray Crystal Structure for N, N’-disubstituted Guanidines. ChemistrySelect
    Academic article
  • Sundby, Eirik; Anthonsen, Thorleif; Perk, L; Aasen, Arne Jørgen; Hansen, TV. (2004) Synthesis of (+)-Goniothalamin and its Enantiomer by Combination of Lipase Catalyzed Resolution and Alkene Metathesis. Tetrahedron
    Academic article
  • Sundby, Eirik; Holt, Jarle; Vik, Anders; Anthonsen, Thorleif. (2004) Chemoenzymatic synthesis of (2S)- and (2R)-2-(1,3-dithian-2-ylmethyl)oxirane. European Journal of Organic Chemistry
    Academic article
  • Hoff, Bård Helge; Sundby, Eirik. (2017) Is literature data useful for identifying enzyme catalysts for new substrates? A case study on reduction of 1-aryl-2-alkanoates. Bioorganic chemistry (Print)
    Academic article
  • Sørum, Christopher; Simic, Nebojsa; Sundby, Eirik; Hoff, Bård Helge. (2010) 1H,13C and 19F NMR data of N-substituted 6-(4-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amines in DMSO-d6. Magnetic Resonance in Chemistry
    Academic article
  • Esmurziev, Aslan; Simic, Nebojsa; Hoff, Bård Helge; Sundby, Eirik. (2010) Synthesis and Structure Elucidation of Benzoylated Deoxyfluoropyranosides. Journal of carbohydrate chemistry
    Academic article
  • Esmurziev, Aslan; Sundby, Eirik; Hoff, Bård Helge. (2009) Regioselective C-6 Hydrolysis of Methyl O-Benzoyl-pyranosides Catalysed by Candida Rugosa Lipase. European Journal of Organic Chemistry
    Academic article
  • Esmurziev, Aslan; Simic, N.; Sundby, Eirik; Hoff, Bård Helge. (2009) H-1 and C-13 NMR data of methyl tetra-O-benzoyl-D-pyranosides in acetone-d(6). Magnetic Resonance in Chemistry
    Academic article
  • Merugu, Srinivas Reddy; Selmer-Olsen, Sigrid M.E.; Johansen, Camilla; Sundby, Eirik; Hoff, Bård Helge. (2024) Synthetic Routes to 2-aryl-1H-pyrrolo[2,3-b]pyridin-4-amines: Cross-Coupling and Challenges in SEM-Deprotection. Molecules
    Academic article
  • Elumalai, Vijayaragavan; Eigner, Václav; Janjua, Nicholas Alexander; Åstrand, Per-Olof Harald; Visnes, Torkild; Sundby, Eirik; Hoff, Bård Helge. (2024) X-ray Structure of Eleven New N,N′-Substituted Guanidines: Effect of Substituents on Tautomer Structure in the Solid State. Crystals
    Academic article
  • Jacobsen, Elisabeth Egholm; Anthonsen, Thorleif; El-Behairy, Mohammed Farrag; Sundby, Eirik; Aboul-Enein, Mohamed Nabil; Attia, Mohamed Ibrahim; El-Azzouny, Aida Abd El-Sattar; Amin, Kamilia M.; Abdel-Rehim, Mohamed. (2012) Lipase Catalysed Kinetic Resolution of Stiripentol. International Journal of Chemistry
    Academic article
  • Fuglseth, Erik; Sundby, Eirik; Hoff, Bård Helge. (2009) Ruthenium-catalysed asymmetric transfer hydrogenation of para-substituted alpha-fluoroacetophenones. Journal of fluorine chemistry
    Academic article
  • Fuglseth, Erik; Sundby, Eirik; Bruheim, Per; Hoff, Bård Helge. (2008) Asymmetric reduction using (R)-MeCBS and determination of absolute configuration of para-substituted 2-fluoroarylethanols. Tetrahedron: asymmetry
    Academic article
  • Sundby, Eirik; Han, Jin; Kaspersen, Svein Jacob; Hoff, Bård Helge. (2015) In vitro baselining of new pyrrolopyrimidine EGFR-TK inhibitors with Erlotinib. European Journal of Pharmaceutical Sciences
    Academic article
  • El-Behairy, Mohammed Farrag; Sundby, Eirik. (2016) One-step lipase-catalysed preparation of eslicarbazepine. RSC Advances
    Academic article
  • Bugge, Steffen; Skjønsfjell, Ellen Martine; Willumsen, Fredrik Bysting; Sundby, Eirik; Hoff, Bård Helge. (2014) Improved and Scalable Preparation of 6-Bromo-4-Chlorothieno[2,3-d]Pyrimidine. Chemistry of Heterocyclic Compounds
    Academic article
  • Sundby, Eirik; Perk, Lars; Anthonsen, Thorleif; Aasen, Arne Jørgen; Hansen, Trond Vidar. (2004) Synthesis of (+)-goniothalamin and its enantiomer by combination of lipase catalyzed resolution and alkene metathesis. Tetrahedron
    Academic article
  • Sundby, Eirik; Holt, Jarle; Vik, Anders; Anthonsen, Thorleif. (2004) Chemoenzymatic synthesis of (2S)- and (2R)-2-(1,3-dithian-2-ylmethyl)oxirane. European Journal of Organic Chemistry
    Academic article
  • Bjørnstad, Frithjof Andreas; Havik, Simen; Aarhus, Thomas Ihle; Mahdi, Iktedar; Unger, Anke; Habenberger, Peter; Degenhart, Carsten; Eickhoff, Jan; Klebl, Bert M.; Sundby, Eirik. (2024) Pyrrolopyrimidine based CSF1R inhibitors: Attempted departure from Flatland. European Journal of Medicinal Chemistry
    Academic article
  • Bugge, Steffen; Kaspersen, Svein Jacob; Sundby, Eirik; Hoff, Bård Helge. (2012) Route selection in the synthesis of C-4 and C-6 substituted thienopyrimidines. Tetrahedron
    Academic article
  • Kaspersen, Svein Jacob; Sundby, Eirik; Charnock, Colin; Hoff, Bård Helge. (2012) Activity of 6-aryl-pyrrolo[2,3-d]pyrimidine-4-amines to Tetrahymena. Bioorganic chemistry (Print)
    Academic article
  • Sundby, Eirik; Haugen, Ingrid Naterstad. (2020) Comparison of Students' Perceived Learning in Two Similar Lab Courses with Different Teaching Staffs. Universal Journal of Educational Research
    Academic article
  • Slungård, Sigrid Volden; Krakeli, Tor-Arne; Thvedt, Thor Håkon Krane; Fuglseth, Erik; Sundby, Eirik; Hoff, Bård Helge. (2011) Investigation into the enantioselection mechanism of ruthenium-arene-diamine transfer hydrogenation catalysts using fluorinated substrates. Tetrahedron
    Academic article
  • Anthonsen, Thorleif; Hoff, Bård Helge; Hofsløkken, Nini; Skattebøl, Lars; Sundby, Eirik. (1999) Synthesis of 1,3-dithianes and 1,3-dithiolanes. Baker´s yeast reduction and lipase-catalyzed resolution for synthesis of enantiopure derivatives. Acta Chemica Scandinavica
    Academic article
  • Anthonsen, Thorleif; DÁrrigo, P; Pedrocche-Fantoni, G; Secundo, F; Servi, Stefano; Sundby, Eirik. (1999) Phospholipid hydrolysis in organic solvents catalysed by immobilised Phospholipase C. Journal of Molecular Catalysis B: Enzymatic
    Academic article
  • Blindheim, Fredrik Heen; Olsen, Cecilie Elisabeth; Søgaard, Caroline Krogh; Otterlei, Marit; Sundby, Eirik; Hoff, Bård Helge. (2021) Synthetic Strategies towards Imidazopyridinones and 7-Azaoxindoles and their Evaluation as Antibacterial Agents. European Journal of Organic Chemistry
    Academic article
  • Reiersølmoen, Ann Christin; Aarhus, Thomas Ihle; Eckelt, Sarah; Nørsett, Kristin Gabestad; Sundby, Eirik; Hoff, Bård Helge. (2019) Potent and selective EGFR inhibitors based on 5-aryl-7H-pyrrolopyrimidin-4-amines. Bioorganic chemistry (Print)
    Academic article
  • Sundby, Eirik; Zotti, Martha De; Anthonsen, Thorleif. (2003) The Enantioselectivity of Reduction of Ethyl 4-bromo-3-oxobutanoate catalyzed by Geotrichum candidum depends on the Cofactor. Journal of Molecular Catalysis B: Enzymatic
    Academic article
  • Sundby, Eirik; Azerad, Robert; Anthonsen, Thorleif. (1998) 2,2-Dimethyl-1,3-propanediol as protective group promotes microbial hydroxylation of cis bicyclo[3.3.0]octane-3,7-dione. Biotechnology Letters
    Academic article
  • Bugge, Steffen; Kaspersen, Svein Jacob; Larsen, Synne; Nonstad, Unni; Bjørkøy, Geir; Sundby, Eirik; Hoff, Bård Helge. (2014) Structure-activity study leading to identification of a highly active thienopyrimidine based EGFR inhibitor. European Journal of Medicinal Chemistry
    Academic article
  • Kaspersen, Svein Jacob; Han, Jin; Nørsett, Kristin; Rydså, Line; Kjøbli, Eli; Bugge, Steffen; Bjørkøy, Geir; Sundby, Eirik; Hoff, Bård Helge. (2014) Identification of new 4-N-substituted 6-aryl-7H-pyrrolo[2,3-d]pyrimidine-4- amines as highly potent EGFR-TK inhibitors with Src-family activity. European Journal of Pharmaceutical Sciences
    Academic article
  • Reimers, Arne; Østby, Lene; Stuen, Ina; Sundby, Eirik. (2011) Expression of UDP-glucuronosyltransferase 1A4 in human placenta at term. European journal of drug metabolism and pharmacokinetics
    Academic article
  • Esmurziev, Aslan; Reimers, Arne; Andreassen, Trygve; Simic, Nebojsa; Sundby, Eirik; Hoff, Bård Helge. (2012) Benzoylated uronic Acid building blocks and synthesis of N-uronate conjugates of lamotrigine. Molecules
    Academic article
  • Aarhus, Thomas Ihle; Bjørnstad, Frithjof Andreas; Wolowczyk, Camilla Izabel; Larsen, Kristin Uhlving; Rognstad, Line; Leithaug, Trygve; Unger, Anke; Habenberger, Peter; Wolf, Alexander; Bjørkøy, Geir. (2023) Synthesis and Development of Highly Selective Pyrrolo[2,3-d]pyrimidine CSF1R Inhibitors Targeting the Autoinhibited Form. Journal of Medicinal Chemistry
    Academic article
  • Han, Jin; Kaspersen, Svein Jacob; Nervik, Sondre; Nørsett, Kristin; Sundby, Eirik; Hoff, Bård Helge. (2016) Chiral 6-aryl-furo[2,3-d]pyrimidin-4-amines as EGFR inhibitors. European Journal of Medicinal Chemistry
    Academic article
  • Aarhus, Thomas Ihle; Teksum, Vilde; Unger, Anke; Habenberger, Peter; Wolf, Alexander; Eickhoff, Jan; Klebl, Bert; Wolowczyk, Camilla Izabel; Bjørkøy, Geir; Sundby, Eirik. (2023) Negishi Cross-Coupling in the Preparation of Benzyl Substituted Pyrrolo[2,3-d]pyrimidine Based CSF1R Inhibitors. European Journal of Organic Chemistry
    Academic article
  • Sundby, Eirik; Anthonsen, Thorleif; Andersen, Morten Myhre; Hoff, Bård Helge. (2002) Lipase catalysed resolution and microbial reduction for obtaining enantiopure 1-(2-thienyl)alkanols. ARKIVOC
    Academic article
  • Cherukupalli, Srinivasulu; Karlsen, Morten; Hoff, Bård Helge; Sundby, Eirik. (2025) Design and Synthesis of a 18F-Radiolabeled Pyrrolo[2,3-d]pyrimidine Ligand as a CSF1R Receptor PET Imaging Agent. Journal of labelled compounds & radiopharmaceuticals
    Academic article
  • Østby, Lene; Sundby, Eirik; Jakobsen, Anita Nordeng. (2024) Authentic Hands-On Learning Approaches for Bulky Student Cohorts in General Chemistry Laboratory Using Case and Peer Assessment. Journal of Chemical Education
    Academic article
  • Østby, Lene; Sundby, Eirik; Krøkje, Åse. (2006) Evaluation of CYP1A protein induction, biotransformation capacity and DNA adduct formation in a rat hepatoma cell line (FAO), as biomarkers of organic contamination in environmental soil samples. Water, Air and Soil Pollution
    Academic article
  • Olsen, Cecilie Elisabeth; Blindheim, Fredrik Heen; Søgaard, Caroline Krogh; Røst, Lisa M.; Singleton, Amanda; Bergum, Olaug Elisabeth Torheim; Bruheim, Per; Otterlei, Marit; Sundby, Eirik; Hoff, Bård Helge. (2022) Halogenated Pyrrolopyrimidines with Low MIC on Staphylococcus aureus and Synergistic Effects with an Antimicrobial Peptide. Antibiotics
    Academic article
  • Thvedt, Thor Håkon Krane; Kaasa, Kristin; Sundby, Eirik; Charnock, Colin; Hoff, Bård Helge. (2013) Chiral N-benzyl-N-methyl-1-(naphthalen-1-yl)ethanamines and their in vitro antifungal activity against Cryptococcus neoformans, Trichophyton mentagrophytes and Trichophyton rubrum. European Journal of Medicinal Chemistry
    Academic article
  • Petrovic, Voin; Olaisen, Camilla; Sharma, Animesh; Nepal, Anala; Bugge, Steffen; Sundby, Eirik; Hoff, Bård Helge; Slupphaug, Geir; Otterlei, Marit. (2017) On-column trypsinization allows for re-use of matrix in modified multiplexed inhibitor beads assay. Analytical Biochemistry
    Academic article
  • Ali, Mohammed Farrag Mohammed; Sundby, Eirik. (2013) Synthesis of the antiepileptic (R)-Stiripentol by a combination of lipase catalyzed resolution and alkene metathesis. Tetrahedron: asymmetry
    Academic article
  • Hoff, Bård Helge; Sundby, Eirik. (2013) Preparation of pharmaceutical important fluorinated 1-arylethanols using isolated enzymes. Bioorganic chemistry (Print)
    Academic literature review
  • Willumsen, Fredrik Bysting; Bugge, Steffen; Sundby, Eirik; Hoff, Bård Helge. (2017) Investigation of Heck coupling on 6-bromo[2,3-d]thienopyrimidines for construction of new EGFR inhibitor lead structures. RSC Advances
    Academic article
  • Aarhus, Thomas Ihle; Eickhoff, Jan; Klebl, Bert; Unger, Anke; Boros, Johanna; Choidas, Axel; Zischinsky, Mia-Lisa; Wolowczyk, Camilla Izabel; Bjørkøy, Geir; Sundby, Eirik. (2023) A highly selective purine-based inhibitor of CSF1R potently inhibits osteoclast differentiation. European Journal of Medicinal Chemistry
    Academic article
  • Han, Jin; Sundby, Eirik; Hoff, Bård Helge. (2013) Solvent selection in synthesis of 4-(1-arylfluoroethoxy)quinazolines and thienopyrimidines. Journal of fluorine chemistry
    Academic article
  • Kaspersen, Svein Jacob; Sørum, Christopher; Willassen, Veronica; Fuglseth, Erik; Kjøbli, Eli; Bjørkøy, Geir; Sundby, Eirik; Hoff, Bård Helge. (2011) Synthesis and in vitro EGFR (ErbB1) tyrosine kinase inhibitory activity of 4-N-substituted 6-aryl-7H-pyrrolo[2,3-d]pyrimidine-4-amines. European Journal of Medicinal Chemistry
    Academic article
  • Thvedt, Thor Håkon Krane; Kristensen, Tor Erik Holt; Sundby, Eirik; Hansen, Tore; Hoff, Bård Helge. (2011) Enantioselectivity, swelling and stability of 4-hydroxyprolinol containing acrylic polymer beads in the asymmetric reduction of ketones. Tetrahedron: asymmetry
    Academic article

Report

  • Sundby, Eirik. (2007) Lynkurs i organisk kjemi for ikke-kjemikere. KMT/AFT
    Working paper
  • Sundby, Eirik. (2007) Polyfunksjonell navnsetting. KMT/AFT
    Working paper
  • Sundby, Eirik; Frommholz, David. (2008) Conversion of Cod Liver Oil to Fatty Acid Methyl Esters Catalyzed by Various Lipases in a Solvent-free system. HiST
    Research report

Student thesis or dissertation

  • Sundby, Eirik. (2003) Biological reductions and esterifications for the production of enantiopure secondary alcohols : chemo-enzymatic synthesis of chiral building blocks with sulphur-containing rings. Norges teknisk-naturvitenskapelige universitet
    Doctoral thesis

Teaching

Courses

  • IMAK2021 - Organic Chemistry for Engineers
  • TMT4500 - Materials Technology, Specialization Project
  • IMAK2022 - Applied Organic Chemistry with Biochemistry
  • IMAK3002 - Bachelor Thesis for Engineers, Chemistry
  • TKJE1016 - General and Organic Chemistry
  • IMAK2003 - Organic Chemistry and Biomolecules 2
  • TKJE1006 - General Chemistry
  • MT8218 - Advanced Materials Science
  • IMAK2008 - Instrumental analysis and biopolymers

Outreach

2026

  • Conference poster
    Kristiansen, Tonje Leine; Paustian, Sophia Tiada; Sundby, Eirik; Hoff, Bård Helge. (2026) 4-(Arylmethoxy)phenol Building Blocks and Routes for Kinase Inhibitors. OKV39 Organisk Kjemisk Vintermøte
  • Conference poster
    Gabestad, Maja; Hoff, Bård Helge; Sundby, Eirik; Cherukupalli, Srinivasulu. (2026) Conformation specific inhibition of colony stimulated factor 1 receptor. OKV39 Organisk Kjemisk Vintermøte
  • Conference poster
    Nedregaard, Kristine Mortensen; Sundby, Eirik; Hoff, Bård Helge. (2026) Identifying cheaper and more sustainable protection groups for pyrrolopyrimidine chemistry. OKV39 Organisk Kjemisk Vintermøte
  • Conference poster
    Rolfsen, Jacob Strand; Cherukupalli, Srinivasulu; Sundby, Eirik; Hoff, Bård Helge. (2026) Triazole-Functionalized 7-Azaindoles: A synthetic Study Using Sonogashira Cross-Coupling and Copper-Catalyzed Azide-Alkyne Cycloaddition. OKV39 Organisk Kjemisk Vintermøte
  • Conference poster
    Cieplak, Aleksandra; Cherukupalli, Srinivasulu; Sundby, Eirik; Hoff, Bård Helge. (2026) Synthesis towards irreversible inhibitors of the CSF1R tyrosine kinase. OKV39 Organisk Kjemisk Vintermøte

2025

  • Conference poster
    Hetland, Emma Li Stangeland; Cherukupalli, Srinivasulu; Sundby, Eirik; Hoff, Bård Helge. (2025) Synthetic studies towards drug-dye conjugates indented for CSF1R mechanistical studies. OKV38-Organisk Kjemisk Vintermøte 2025
  • Conference poster
    Rolfsen, Jacob Strand; Hoff, Bård Helge; Sundby, Eirik; Cherukupalli, Srinivasulu. (2025) Synthetic studies of novel 3,5-diarylated-7-azaindoles for possible pharmacological evaluation as DYRK1A inhibitors. OKV38-Organisk Kjemisk Vintermøte 2025
  • Conference poster
    Merugu, Srinivas Reddy; Sundby, Eirik; Hoff, Bård Helge. (2025) Routes to specific 7-azaindoles: cross-coupling, and challenges in SEM-deprotection. OKV38-Organisk Kjemisk Vintermøte 2025
  • Conference poster
    Sakariassen, Sivert; Raastad, Andreas; Sundby, Eirik; Hoff, Bård Helge. (2025) Synthesis of 5-aryl-7H[2,3-d]pyrimidine-4-amines for inhibition of CDC2 like kinase 1 (CLK1). OKV38-Organisk Kjemisk Vintermøte 2025
  • Lecture
    Strøm, Silje Iren; Olsen, Cecilie Elisabeth; Sundby, Eirik; Hoff, Bård Helge. (2025) Synthesis of Dopamine-Carbazole Conjugates as Potential Inhibitors of the Bacterial DNA Sliding Clamp. OKV38-Organisk Kjemisk Vintermøte 2025
  • Conference poster
    Cherukupalli, Srinivasulu; Karlsen, Morten; Hoff, Bård Helge; Sundby, Eirik. (2025) Design and synthesis of a 18F-radiolabelled pyrrolo[2,3-d)pyrimidine ligand as CSF1R receptor PET imaging agent. OKV38-Organisk Kjemisk Vintermøte 2025

2024

  • Lecture
    Hoff, Bård Helge; Sundby, Eirik. (2024) Pyrrolopyrimidines and Purines as CSF1R inhibitors. 7th International Conference on Biocatalysis in Non-conventional Media
  • Conference poster
    Strøm, Silje Iren; Markussen, Solveig Auranaune; Olsen, Cecilie Elisabeth; Sundby, Eirik; Hoff, Bård Helge. (2024) Synthesis of carbazole derivatives for testing as antibacterial agents. OKV37-Organisk Kjemisk Vintermøte 2024
  • Conference poster
    Janjua, Nicholas A.; Koch, Sebastian P; Vijayyaragavan, Elumalai; Eigner, Václav; Sundby, Eirik; Hoff, Bård Helge. (2024) Synthesis and crystal structure of N,N’-disubstituted guanidines. OKV37-Organisk Kjemisk Vintermøte 2024
  • Lecture
    Olsen, Cecilie Elisabeth; Sundby, Eirik; Hoff, Bård Helge. (2024) Synthesis and evaluation of tetrahydrobarbazoles targeting the b sliding clamp. OKV37-Organisk Kjemisk Vintermøte 2024

2023

  • Conference poster
    Bathen, Mina; Olsen, Cecilie Elisabeth; Sundby, Eirik; Hoff, Bård Helge. (2023) Synthesis of aniline substituted heterocycles: searching for anticancer agents. Organisk Kjemisk Vintermøte-OKV36
  • Conference poster
    Elumalai, Vijayaragavan; Visnes, Torkild; Sundby, Eirik; Hoff, Bård Helge. (2023) Synthesis of pyrimidinyl guanidine derivatives for medicinal applications. Organisk Kjemisk Vintermøte-OKV36
  • Conference poster
    Svergja, Hanne; Olsen, Cecilie Elisabeth; Sundby, Eirik; Hoff, Bård Helge. (2023) Acid catalyzed amination of 4-chloro-pyrrolo[2,3-d]pyrimidines with anilines. Organisk Kjemisk Vintermøte-OKV36
  • Conference poster
    Østby, Lene; Sundby, Eirik; Steinsbekk, Kristin Solum; Mehli, Lisbeth; Nonstad, Liv Anita; Ekeberg, IS; Paulsen, H.; Jakobsen, Anita Nordeng. (2023) Fra kokebok til kontekstualisering i generell kjemi: Erfaringer fra implementering av casebasert laboratorieundervisning og medstudentvurdering. MNT-konferansen
  • Conference lecture
    Olsen, Cecilie Elisabeth; Blindheim, Fredrik Heen; Sundby, Eirik; Hoff, Bård Helge. (2023) Halogenated pyrrolopyrimidines with antibacterial activity towards S. aureus. Organisk Kjemisk Vintermøte-OKV36
  • Conference lecture
    Bjørnstad, Frithjof A; Sundby, Eirik; Hoff, Bård Helge. (2023) Directed lithiation of protected 4-chloropyrrolopyrimidine: addition to aldehydes and ketones aided by bis(2-dimethylaminoethyl)ether. Organisk Kjemisk Vintermøte-OKV36

2022

  • Conference lecture
    Wahl, Markus Solberg; Boucher, Susanne Aspen; Lamb, Jacob Joseph; Sundby, Eirik; Thomas, Peter James; Hjelme, Dag Roar; Burheim, Odne Stokke. (2022) Towards in-situ state of health monitoring of lithium-ion batteries using internal fiber-optic sensors. 241st ECS Meeting
  • Conference lecture
    Elumalai, Vijayaragavan; Olaisen, Camilla; Naderi, Sheida; To, Vu; Wågbø, Ane Marit; Klinkenberg, Geir; Sundby, Eirik; Hoff, Bård Helge; Visnes, Torkild. (2022) Small molecule inhibitors to modulate DNA repair-mediated gene regulation. NORBER
  • Conference lecture
    Elumalai, Vijayaragavan; Olaisen, Camilla; Naderi, Sheida; To, Vu; Wågbø, Ane Marit; Klinkenberg, Geir; Sundby, Eirik; Hoff, Bård Helge; Visnes, Torkild. (2022) Small molecule inhibitors to modulate DNA repair-mediated gene regulation. Oslo Epigenetics Symposium
  • Conference lecture
    Jakobsen, Anita Nordeng; Steinsbekk, Kristin Solum; Østby, Lene; Sundby, Eirik; Kjøbli, Eli; Mehli, Lisbeth. (2022) Studentaktiv læring og vurdering i «store» grunnlagsemner; Hvordan få med oss alle?. Læringsfestivalen

2020

  • Conference poster
    Olsen, Cecilie Elisabeth; Blindheim, Fredrik Heen; Sundby, Eirik; Hoff, Bård Helge. (2020) Synthesis of an Imidazopyridinone-Based Thymidylate Kinase Inhibitor. Organisk kjemisk Vintermøte 2020
  • Conference lecture
    Blindheim, Fredrik Heen; Hoff, Bård Helge; Sundby, Eirik. (2020) Towards bacterial thymidylate kinase inhibitors. Organisk kjemisk Vintermøte 2020
  • Conference poster
    Aarhus, Thomas Ihle; Sundby, Eirik; Hoff, Bård Helge. (2020) Syntetic reactions in the pursuit of bioactive pyrrolo[2,3-d]pyrimidines. Organisk kjemisk Vintermøte 2020

2019

  • Conference poster
    Bygdås, Håkon Steinholt; Aarhus, Thomas Ihle; Sundby, Eirik; Hoff, Bård Helge. (2019) Evaluation of protective groups in synthesis towards substituted purines. Organisk Kjemisk Vintermøte OKV34
  • Conference poster
    Selmer-Olsen, Sigrid; Aarhus, Thomas Ihle; Sundby, Eirik; Hoff, Bård Helge. (2019) Strategies towards substituted pyrrolopyridines. Organisk Kjemisk Vintermøte OKV34
  • Conference poster
    Aarhus, Thomas Ihle; Reiersølmoen, Ann Christin; Nørsett, Kristin Gabestad; Sundby, Eirik; Hoff, Bård Helge. (2019) Highly potent and selective EGFR inhibitors based on 5-aryl-7H-pyrrolopyrimidin-4-amines. Organisk Kjemisk Vintermøte OKV34
  • Conference poster
    Blindheim, Fredrik Heen; Hoff, Bård Helge; Sundby, Eirik. (2019) Synthesis of novel thymidylate monophosphate kinase inhibitors. Organisk Kjemisk Vintermøte OKV34
  • Conference poster
    Rognstad, Line; Tsui, Hay Man Hilde; Aarhus, Thomas Ihle; Sundby, Eirik; Hoff, Bård Helge. (2019) Synthesis of 4,6-disubstituted pyrrolo[2,3,d]pyrimidines. Organisk Kjemisk Vintermøte OKV34
  • Conference poster
    Haugen, Ingrid Naterstad; Sundby, Eirik. (2019) Sammenligning av gjennomføring, ressursbruk og læringskvalitet på like lab-kurs ved IMA. Læringsfestivalen 2019

2018

  • Lecture
    Hoff, Bård Helge; Sundby, Eirik. (2018) Synthesis of fused pyrimidines and their EGFR inhibitory activity. Chemtrends-2018
  • Conference poster
    Ramsnes, Andreas B.; Aarhus, Thomas Ihle; Sundby, Eirik; Hoff, Bård Helge. (2018) Synthesis of thienopyrimidine based EGFR inhibitors. Organisk Kjemisk Vintermøte OKV33
  • Conference poster
    Skinderhaug, Jori; Hjøllo, Elisabeth; Aarhus, Thomas Ihle; Sundby, Eirik; Hoff, Bård Helge. (2018) Synthetic strategies towards substituted purines. Organisk Kjemisk Vintermøte OKV33

2017

  • Conference poster
    Johansen, Camilla; Aarhus, Thomas Ihle; Sundby, Eirik; Hoff, Bård Helge. (2017) Synthetic strategies towards substituted pyrrolopyridines. Organisk Kjemisk Vintermøte OKV32

2016

  • Conference poster
    Reiersølmoen, Ann Christin; Han, Jin; Sundby, Eirik; Hoff, Bård Helge. (2016) Synthesis of pyrrolopyrimidines with acrylate warehead for irreversible inhibition. Organisk Kjemisk vintermøte OKV31
  • Conference poster
    Larsen, Kristin Uhlving; Han, Jin; Aarhus, Thomas Ihle; Sundby, Eirik; Hoff, Bård Helge. (2016) Synthesis of pyrrolopyrimidines for use in SAR study of CSF-1R kinase. Organisk Kjemisk vintermøte OKV31
  • Conference lecture
    Han, Jin; Sundby, Eirik; Hoff, Bård Helge. (2016) Balancing potency, metabolic stability and permeability in pyrrolopyrimidine based EGFR-TK inhibitors. Organisk kjemisk vintermøte OKV31

2015

  • Conference poster
    Hoff, Bård Helge; Sundby, Eirik; Han, Jin; Bugge, Steffen. (2015) Thieno- and Pyrrolo[2,3-d]pyrimidine base EGFR inhibitors and their ADME profile. , International Symposium in Synthetic and Medicinal Chemistry
  • Conference poster
    Buene, Audun Formo; Bugge, Steffen; Sundby, Eirik; Hoff, Bård Helge. (2015) Synthesis of amide containing thienopyrimidines. Organisk kjemisk vintermøte OKV 30
  • Conference poster
    Willumsen, Fredrik Bysting; Bugge, Steffen; Sundby, Eirik; Hoff, Bård Helge. (2015) Optimization of Heck reaction on the thienopyrimidine scaffold. Organisk kjemisk vintermøte OKV 30
  • Conference poster
    Bekkevard, Pål Unnerud; Han, Jin; Sundby, Eirik; Hoff, Bård Helge. (2015) Instability of 7N-protected pyrrolo[2,3-d]pyrimidines. Organisk kjemisk vintermøte
  • Lecture
    Han, Jin; Kaspersen, Svein Jacob; Sundby, Eirik; Hoff, Bård Helge. (2015) Highly potent pyrrolo[2,3-d]pyrimidines as EGFR-TK inhibitors with interesting Src-familiy and CSF1R activity. Organisk kjemisk Vintermøte OKV 30
  • Conference poster
    Nervik, Sondre; Han, Jin; Sundby, Eirik; Hoff, Bård Helge. (2015) Furopyrimidines as EGFR tyrosine kinase inhibitors. Organisk kjemisk vintermøte OKV 30
  • Conference poster
    Henriksen, Silje; Han, Jin; Sundby, Eirik; Hoff, Bård Helge. (2015) Chiral pyrrolopyrimidine based EGFR inhibitors. Organisk kjemisk vintermøte OKV 30
  • Conference lecture
    Hoff, Bård Helge; Sundby, Eirik. (2015) Thieno- and pyrrolopyrimidine based epidermal growth factor inhibitors: synthesis, SAR study, cellular profiling and ADME challenges. Lecture at Bar Ilan University

2014

  • Conference lecture
    Bugge, Steffen; Kaspersen, Svein Jacob; Sundby, Eirik; Hoff, Bård Helge. (2014) Structure-activity study leading to the identification of a highly active thienopyrimidine based EGFR inhibitor. Organisk kjemisk vintermøte 2014
  • Conference poster
    Moen, Ingri Ullestad; Sylte, Kent-Ove Kragseth; Bugge, Steffen; Sundby, Eirik; Hoff, Bård Helge. (2014) Fragment based approach in the search for new kinase inhibitors. Organisk kjemisk vintermøte 2014
  • Conference poster
    Han, Jin; Bartling, Christian; Sundby, Eirik; Hoff, Bård Helge. (2014) Challanges in synthesis of electron rich furopyrimidines. Organisk kjemisk vintermøte 2014
  • Conference poster
    Bugge, Steffen; Kaspersen, Svein Jacob; Sundby, Eirik; Hoff, Bård Helge. (2014) Use of the thienopyrimidine scaffold for development of new EGFR-TK inhibitors. Kinase 2014: Past, Present and Beyond. 19-20 May 2014
  • Conference poster
    Han, Jin; Kaspersen, Svein Jacob; Sundby, Eirik; Hoff, Bård Helge. (2014) Highly potent pyrrolo[2,3-d]pyrimidines as EGFR-TK inhibitors with interesting Src-family and CSF1R activity. Kinase 2014: Past, Present and Beyond. 19-20 May 2014

2013

  • Conference lecture
    Kaspersen, Svein Jacob; Bugge, Steffen; Sundby, Eirik; Hoff, Bård Helge. (2013) Pyrrolopyrimidines as Potential EGFR Kinase Inhibitors. The 24. International Society of Heterocyclic Chemistry Congress
  • Conference poster
    Han, Jin; Sundby, Eirik; Hoff, Bård Helge. (2013) Identifying mild coupling conditions for fluorinated alcohols. Det 28. Organisk kjemiske vintermøte
  • Conference poster
    Bugge, Steffen; Kaspersen, Svein Jacob; Lange, Sandra; Sundby, Eirik; Hoff, Bård Helge. (2013) Structure-activity study of thienopyrimidines as EGFR tyrosine kinase inhibitors. Det 28. Organisk kjemiske vintermøte
  • Conference poster
    Rydså, Line; Kaspersen, Svein Jacob; Sundby, Eirik; Hoff, Bård Helge. (2013) Investigation of the synthesis of 6-iodo-4-chloroprrolo[2,3-d]pyrimidine. Det 28. Organisk kjemiske vintermøte
  • Conference poster
    Skjønsfjell, Ellen Martine; Bugge, Steffen; Sundby, Eirik; Hoff, Bård Helge. (2013) Investigation and scale up of the synthesis of 6-bromo-4-chlorothieno[2,3-d]pyrimidine. Det 28. Organisk kjemiske vintermøte
  • Conference lecture
    Jacobsen, Elisabeth Egholm; El-Behairy, Mohammed Farrag; Sundby, Eirik; Anthonsen, Thorleif. (2013) Antiepileptic Drug (R)-Stiripentol by Lipase Catalysis. Drug Discovery & Therapy World Congress 2013

2012

  • Conference lecture
    Bugge, Steffen; Kaspersen, Svein Jacob; Sundby, Eirik; Hoff, Bård Helge. (2012) Route selection in synthesis of thienopyrimidines. Organisk kjemisk vintermøte 2012
  • Conference lecture
    Kaspersen, Svein Jacob; Bjørkøy, Geir; Sundby, Eirik; Hoff, Bård Helge. (2012) In vitro testing of pyrrolopyrimidines as kinase inhibitors. Organisk kjemisk vintermøte 2012
  • Conference poster
    Zolubas, Giedrius; Bugge, Steffen; Thvedt, Thor Håkon Krane; Sundby, Eirik; Hoff, Bård Helge. (2012) Building blocks for thienopyrimidines synthezised using microwave heating. Organisk kjemisk vintermøte
  • Conference poster
    Han, Jin; Larsen, Synne; Kaspersen, Svein Jacob; Sundby, Eirik; Hoff, Bård Helge. (2012) Investigation into the synthesis of 2-aminopyrroles. Organisk kjemisk vintermøte 2012
  • Conference poster
    Jacobsen, Elisabeth Egholm; Sundby, Eirik; El-Behairy, Mohammed Farrag; Anthonsen, Thorleif. (2012) Synthesis of chiral drugs by Candida antarctica lipase A catalysis. 7th CeBiTec Symposium: Bio-integrated Organic Synthesis in Industry:

2011

  • Conference poster
    El-Behairy, Mohammed Farrag; Jacobsen, Elisabeth Egholm; Sundby, Eirik; Skattebøl, Lars; Anthonsen, Thorleif. (2011) Kinetic resolution of dihalocyclopropyl alcohols. COST Action CM0701 Biocatalysis Summer Training School
  • Conference poster
    Thvedt, Thor Håkon Krane; Kaasa, Kristin; Sundby, Eirik; Charnock, Colin; Hoff, Bård Helge. (2011) Chiral derivatives of Butenafine and Terbinafine: synthesis and antifungal activity. 17. European Symposium on Organic Chemistry
  • Conference poster
    Kaspersen, Svein Jacob; Bugge, Steffen; Sundby, Eirik; Hoff, Bård Helge. (2011) Pyrrolo- and thienopyrimidines as potential kinase inhibitors. 17. European Symposium on Organic Chemistry
  • Conference poster
    Kaspersen, Svein Jacob; Bugge, Steffen; Sundby, Eirik; Hoff, Bård Helge. (2011) Pyrrolo-and thienopyrimidines as potential kinase inhibitors. The 2011 PhD Candidate seminar on medicinal technology

2010

  • Conference lecture
    Hoff, Bård Helge; Thvedt, Thor Håkon Krane; Fuglseth, Erik; Sundby, Eirik. (2010) Microwave assisted side chain fluorination of 1-arylethanones. Organisk Kjemisk Vintermøte
  • Conference poster
    Kaspersen, Jacob; Willassen, Veronica; Sundby, Eirik; Hoff, Bård Helge. (2010) Pyrrolopyrimidines as potential kinase inhibitors. Organisk Kjemisk Vintermøte
  • Conference poster
    Thvedt, Thor Håkon Krane; Sundby, Eirik; Hoff, Bård Helge. (2010) Synthesis of new chiral building blocks: 1-aryl-2-fluoroethylamines. Organisk Kjemisk Vintermøte
  • Conference poster
    Slungård, Sigrid; Engøy, Ingemund; Fuglseth, Erik; Sundby, Eirik; Hoff, Bård Helge. (2010) Ruthenium catalysed asymmetric transfer hydrogenation of fluorinated ketones. Organisk Kjemisk Vintermøte
  • Conference lecture
    Esmurziev, Aslan; Hoff, Bård Helge; Sundby, Eirik. (2010) Chemo-enzymatic synthesis of benzoylated hexapyranosides and derivatives. Organisk Kjemisk Vintermøte
  • Conference poster
    Jacobsen, Elisabeth Egholm; Sundby, Eirik; Anthonsen, Thorleif. (2010) Biocatalysis for Green chemistry. The World Forum, University of Cambridge

2009

  • Conference lecture
    Sundby, Eirik. (2009) Enzymatic synthesis of benzoylated uronic acids using lipase hydrolysis and laccase oxidations in tandem. Cascade Chemoenzymatic Processes ¿ New Synergies Between Chemistry and Biochemistry

2008

  • Conference poster
    Fuglseth, Erik; Thvedt, Thor Håkon Krane; Sundby, Eirik; Hoff, Bård Helge. (2008) Asymmetric reduction of 4¿-substituted _a-fluoroacetophenones. OKV 2008
  • Conference poster
    Esmurziev, Aslan; Hoff, Bård Helge; Sundby, Eirik. (2008) Regioselective enzymatic hydrolysis of tetrabenzoylated hexapyranosides. Biocatalysis in Non-Convential Media

2007

  • Conference poster
    Sundby, Eirik; Esmurziev, Aslan. (2007) Synthesis and characterisation of olanzapine N-10-glucuronide and lamotrigin N-2-glucuronide. Chemical synthesis of glucuronides
  • Conference poster
    Pettersen, Nina M.; Liu, Hui-Ling; Zahlsen, Kolbjørn; Sundby, Eirik; Johansen, Jon Eigill. (2007) Designer Internal Standards. OKV 2007

2006

  • Conference poster
    Sundby, Eirik; Johansen, Jon Eigill. (2006) Chemoenzymatic synthesis of PAH-glucuronides. Organisk kjemisk vintermøte
  • Conference poster
    Sundby, Eirik; Stuen, Ina. (2006) (2R,4R)-2,4-dimethyl-1,3-dithian as a chiral acyl anion equivalent. Organisk kjemisk vintermøte

2005

  • Conference lecture
    Sundby, Eirik; Liu, Hui-Ling; Fetzer, John; Johansen, Jon Eigill. (2005) Reference Standards for PAH Analysis and Reasearch. Dioxin 2005/ISPAC 20
  • Interview
    Sundby, Eirik. (2005) Jakten på de gode ideene.
  • Conference poster
    Sundby, Eirik. (2005) Metatese: En molekylær pardans med partnerbytte. Nobelprisen i kjemi 2005 Norsk Kjemisk Selskap Trondheim

2001

  • Conference lecture
    Sundby, Eirik; Zotti, Martha De; Anthonsen, Thorleif. (2001) The enantioselectivity of reduction of ethyl 4-bromo-3-oxobutanoate catalysed by Geotrichum candium depends on the cofactor. Applied Biocatalysis 1980-2020: The future impact of modelling proteins and thermodynamics, 2001, NTNU, Trondheim, Norway
  • Conference poster
    Sundby, Eirik; Holt, Jarle; Anthonsen, Thorleif. (2001) Enantiopure 1-(1,3-dithian-2-yl)-3-halo-2-propanol. Building Blocks for Biologically Active Compounds by Lipase-Catalyzed Kinetic Resolution. Applied Biocatalysis 1980-2020: The future impact of modelling proteins and thermodynamics, 2001, NTNU, Trondheim, Norway
  • Conference poster
    Sundby, Eirik; Holt, Jarle; Anthonsen, Thorleif. (2001) Enantiopure 1-(1,3-dithian-2-yl)-4-halo-2-propanol as Building Blocks for Biologically Active Compounds by Lipase-Catalyzed Kinetic Resolution. 16th Norwegian Organic Chemistry Wintermeeting
  • Conference poster
    Sundby, Eirik; Zotti, Marta De; Anthonsen, Thorleif. (2001) The Enantioselectivity of Reduction of Ethyl 4-bromo-3-oxobutanoate Catalyzed by Geotrichum candidum Depends on the Cofactor. 16th Norwegian Organic Chemistry Wintermeeting

2000

  • Conference lecture
    Anthonsen, Thorleif; Hoff, Bård Helge; Liu, Hui Ling; Sundby, Eirik. (2000) Enantiopure chiral building blocks by biocatalysis. Organisk kjemisk vintermøte
  • Conference poster
    Sundby, Eirik; DeZotti, Marta; Anthonsen, Thorleif. (2000) The enantioselectivity of reduction of ethyl 4-bromo-3-oxobutanoate catalysed by Geotrichum candidum depends on the cofactor. Organic Transformations: Selective Processes and Asymmetric Catalysis, COST D12 Workshop

1999

  • Conference lecture
    Anthonsen, Thorleif; Hoff, Bård Helge; Hoffsløkken, Nini; Skattebøl, Lars; Sundby, Eirik. (1999) Synthesis of Enantiopure 1,3-Dithianes and 1,3-Dithiolanes. 7. Nordic Conference on Biocatalysis in Organic Chemistry
  • Conference poster
    Anthonsen, Thorleif; Hoff, Bård Helge; Liu, Hui-Ling; Sundby, Eirik. (1999) Enantiopure chiral building blocks by biocatalysis. Metal and bio-promoted selective organic transformations. COST D12 Workshop

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