Idun Maria Tokvam Burgos
About
Project: Modelling and optimizing a microbial consortia that produces medium-chain carboxylates from cellulose
Medium-chain carboxylates, such as caproate and caprylic acid, are products with a wide range of uses, including as insecticides and (after conversion) as fuel or medicine. They can be produced through the carboxylate platform, in which a microbial community of bacteria breaks down cellulose and ferments the constituent sugars. The species in such a community live in different types of symbiosis and can cooperate by exchanging metabolites or compete for limited resources. Microbial communities exist in all nooks and crannies of the world, including the stomachs of vertebrates and soil. Their efficient cooperation, stability to perturbations, and wide range of metabolic functions make them ideal for use in complex processes such as in the carboxylate platform.
The motivation for the project is to make better use of the biowaste produced each year, which otherwise would be sent to landfills. It is a collaboration called Cell4Chem under the ERA CoBiotech umbrella, with partners in Germany, France, Spain, and Slovenia. My task is to generate and use mathematical genome-scale metabolic models to guide the design of the ideal microbial community.
Supervisor: Daniel Machado
Publications
2025
-
Burgos, Idun Maria Tokvam;
Øyås, Ove;
Moutinho Luz Machado, Carlos Daniel.
(2025)
Genome-scale metabolic modeling of Ruminiclostridium cellulolyticum: a microbial cell factory for valorization of lignocellulosic biomass.
bioRxiv
Academic article
2024
-
Kobel, Carl Mathias;
Merkesvik, Jenny;
Burgos, Idun Maria Tokvam;
Lai, Wanxin;
Øyås, Ove;
Pope, Phillip.
(2024)
Integrating host and microbiome biology using holo-omics.
Molecular Omics
Academic literature review
-
Kobel, Carl Mathias;
Merkesvik, Jenny;
Burgos, Idun Maria Tokvam;
Lai, Wanxin;
Øyås, Ove;
Pope, Phillip.
(2024)
Integrating host and microbiome biology using holo-omics.
Molecular Omics
Academic article
2022
-
Simensen, Vetle;
Schulz, Christian;
Karlsen, Emil;
Bråtelund, Signe;
Burgos, Idun Maria Tokvam;
Thorfinnsdottir, Lilja Brekke.
(2022)
Experimental determination of Escherichia coli biomass composition for constraint-based metabolic modeling.
PLOS ONE
Academic article
Journal publications
-
Burgos, Idun Maria Tokvam;
Øyås, Ove;
Moutinho Luz Machado, Carlos Daniel.
(2025)
Genome-scale metabolic modeling of Ruminiclostridium cellulolyticum: a microbial cell factory for valorization of lignocellulosic biomass.
bioRxiv
Academic article
-
Kobel, Carl Mathias;
Merkesvik, Jenny;
Burgos, Idun Maria Tokvam;
Lai, Wanxin;
Øyås, Ove;
Pope, Phillip.
(2024)
Integrating host and microbiome biology using holo-omics.
Molecular Omics
Academic literature review
-
Kobel, Carl Mathias;
Merkesvik, Jenny;
Burgos, Idun Maria Tokvam;
Lai, Wanxin;
Øyås, Ove;
Pope, Phillip.
(2024)
Integrating host and microbiome biology using holo-omics.
Molecular Omics
Academic article
-
Simensen, Vetle;
Schulz, Christian;
Karlsen, Emil;
Bråtelund, Signe;
Burgos, Idun Maria Tokvam;
Thorfinnsdottir, Lilja Brekke.
(2022)
Experimental determination of Escherichia coli biomass composition for constraint-based metabolic modeling.
PLOS ONE
Academic article
Outreach
2024
-
LectureBurgos, Idun Maria Tokvam; Øyås, Ove; Moutinho Luz Machado, Carlos Daniel. (2024) Elucidating the roles of bacteria in cellulose- and xylan-enriched communities with genome-scale metabolic models. Centre for Digital Life Norway Norwegian Bioinformatics Days 2024 , Bergen, Norway 2024-05-28 - 2024-05-30
-
PosterStallvik, Andrea; Burgos, Idun Maria Tokvam; Moutinho Luz Machado, Carlos Daniel. (2024) Designing microbial consortia using metabolic modelling – possibilities and limitations. Centre for Digital Life Norway Norwegian Bioinformatics Days 2024 , Bergen, Norway 2024-05-28 - 2024-05-30
2022
-
PosterBurgos, Idun Maria Tokvam; Machado, Daniel. (2022) Modeling The Conversion Of Lignocellulose Into Medium-chain Carboxylates. International Society for Microbial Ecology ISME 18 , Lausanne, Switzerland 2022-08-14 - 2022-08-19