Katja Scheffler
About
Leader of the Neurobiological Laboratory with a strong expertise in the field of aging, neurodegenerative disease, DNA repair, epigenetics, and translational medicine.
My research lab is situated at both the Department of Neurology, St. Olavs Hospital and INB, NTNU which allows conducting high-quality basic research as well as patient-oriented clinical studies.
Research
Neuroepigenetics - Base Modifications in Cognitive Function
Genomic DNA is continuously challenged by endogenous and exogenous oxidative agents, thus preserving genomic integrity is a key for development and health. Base excision repair (BER) is the major pathway for removal of oxidized bases in the genome. BER is initiated by DNA glycosylases, recognizing and excising a broad range of base lesions. However, processing of oxidized base lesions to avoid DNA mutations seems not the main activity of DNA glycosylases but they rather have a novel role in regulating the epigenetic landscape. The main focus of my research is to unravel the molecular mechanism and function of DNA glycosylases in epigenetic remodeling in brain, thus laying the basis for novel diagnostic- and therapeutic strategies for brain-related disorders.
Next-Generation Translational Medicine in Alzheimer's disease
AD is a complex age-related neurodegenerative disorder that affect millions of people worldwide. With the steady growth of life expectancy, AD has become one of the biggest health challenges of our society. The underlying mechanisms that contribute to the development and progression of AD are still not fully understood, and no treatment is available to halt or delay the disease. We aim to adress these challenges by etablishing a platform for patient-derived cell models to reveal novel molecular pathways leading to AD.
Publications
2022
-
Grøntvedt, Gøril Rolfseng;
Sando, Sigrid Botne;
Lauridsen, Camilla;
Bråthen, Geir;
White, Linda Rosemary;
Salvesen, Øyvind.
(2022)
Association of Klotho protein levels and KL-VS heterozygosity with Alzheimer disease and amyloid and tau burden.
JAMA Network Open
Academic article
-
Egiazarian, Milena Armenovna;
Strømstad, Silje;
Sakshaug, Teri;
Núñez Nescolarde, Ana Beatriz;
Bethge, Nicole;
Bjørås, Magnar.
(2022)
Age- and sex-dependent effects of DNA glycosylase Neil3 on amyloid pathology, adult neurogenesis, and memory in a mouse model of Alzheimer's disease.
Free Radical Biology & Medicine
Academic article
-
Tari, Atefe R;
Berg, Helene Haugen;
Videm, Vibeke;
Bråthen, Geir;
White, Linda Rosemary;
Røsbjørgen, Ragnhild.
(2022)
Safety and efficacy of plasma transfusion from exercise - trained donors in patients with early Alzheimer’s disease: protocol for the ExPlas study.
BMJ Open
Article in business/trade/industry journal
2021
-
Hildrestrand, Gunn Annette;
Rolseth, Veslemøy;
Kunath, Nicolas;
Suganthan, Rajikala;
Jensen, Vidar;
Bugaj, Anna Maria.
(2021)
NEIL1 and NEIL2 DNA glycosylases modulate anxiety and learning in a cooperative manner in mice.
Communications Biology
Academic article
-
Sousa, Mirta;
Ye, Jing;
Gomez, Luisa Fernanda Luna;
Hildrestrand, Gunn Annette;
Bjørås, Karine;
Scheffler, Katja.
(2021)
Impact of oxidative DNA damage and the role of DNA glycosylases in neurological dysfunction.
International Journal of Molecular Sciences
Academic literature review
-
Quiles-Jiménez, Ana M T;
Gregersen, Ida;
Segers, Filip;
Skarpengland, Tonje;
Kroustallaki, Pinelopi;
Yang, Kuan.
(2021)
DNA glycosylase Neil3 regulates vascular smooth muscle cell biology during atherosclerosis development.
Atherosclerosis
Academic article
2020
-
Farooq, Amna;
Grønmyr, Sindre;
Omer, Ali Avan;
Rognes, Torbjørn;
Scheffler, Katja;
Bjørås, Magnar.
(2020)
HMST-Seq-Analyzer: A new python tool for differential methylation and hydroxymethylation analysis in various DNA methylation sequencing data.
Computational and Structural Biotechnology Journal
Academic article
-
Scheffler, Katja;
Jalland, Clara Maria Osnes;
Benestad, Sylvie L.;
Moldal, Torfinn;
Ersdal, Cecilie;
Gunnes, Gjermund.
(2020)
DNA glycosylase Neil2 contributes to genomic responses in the spleen during clinical prion disease.
Free Radical Biology & Medicine
Academic article
2019
-
Ystgaard, Martin Bogale;
Scheffler, Katja;
Suganthan, Rajikala;
Bjørås, Magnar;
Ranheim, Trine;
Sagen, Ellen Lund.
(2019)
Neuromodulatory effect of NLRP3 and ASC in neonatal hypoxic ischemic encephalopathy.
Neonatology
Academic article
-
Scheffler, Katja;
Bjørås, Karine Øian;
Bjørås, Magnar.
(2019)
Diverse functions of DNA glycosylases processing oxidative base lesions in brain.
DNA Repair
Academic literature review
2018
-
Scheffler, Katja;
Rachek, Lyudmila;
You, Panpan;
Rowe, Alexander D.;
Wang, Wei;
Kuśnierczyk, Anna.
(2018)
8-oxoguanine DNA glycosylase (Ogg1) controls hepatic gluconeogenesis.
DNA Repair
Academic article
2017
-
Olsen, Maria Belland;
Hildrestrand, Gunn Annette;
Scheffler, Katja;
Vinge, Leif Erik;
Alfsnes, Katrine;
Palibrk, Vuk.
(2017)
NEIL3-Dependent Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture.
Cell reports
Academic article
-
Rolseth, Veslemøy;
Gomez, Luisa Fernanda Luna;
Olsen, Ann-Karin;
Suganthan, Rajikala;
Scheffler, Katja;
Neurauter, Christine Gran.
(2017)
No cancer predisposition or increased spontaneous mutation frequencies in NEIL DNA glycosylases-deficient mice.
Scientific Reports
Academic article
2016
-
Palibrk, Vuk;
Suganthan, Rajikala;
Scheffler, Katja;
Wang, Wei;
Bjørås, Magnar;
Bøe, Stig Ove.
(2016)
PML regulates neuroprotective innate immunity and neuroblast commitment in a hypoxic–ischemic encephalopathy model.
Cell Death & Disease
Academic article
-
Jalland, Clara Maria Osnes;
Scheffler, Katja;
Benestad, Sylvie Lafond;
Moldal, Torfinn;
Ersdal, Cecilie;
Gunnes, Gjermund.
(2016)
Neil3 induced neurogenesis protects against prion disease during the clinical phase.
Scientific Reports
Academic article
-
Skarpengland, Tonje;
Dahl, Tuva Børresdatter;
Skjelland, Mona;
Scheffler, Katja;
Sousa, Mirta;
Gregersen, Ida.
(2016)
Enhanced base excision repair capacity in carotid atherosclerosis may protect nuclear DNA but not mitochondrial DNA.
Free Radical Biology & Medicine
Academic article
-
Skarpengland, Tonje;
Holm, Sverre;
Scheffler, Katja;
Gregersen, Ida;
Dahl, Tuva Børresdatter;
Suganthan, Rajikala.
(2016)
Neil3-dependent base excision repair regulates lipid metabolism and prevents atherosclerosis in Apoe-deficient mice.
Scientific Reports
Academic article
-
Wang, Wei;
Scheffler, Katja;
Esbensen, Qin Ying;
Eide, Lars.
(2016)
Quantification of DNA Damage by Real-Time qPCR.
Springer
Chapter
2015
-
Wang, Wei;
Esbensen, Qin Ying;
Scheffler, Katja;
Eide, Lars.
(2015)
Analysis of Mitochondrial DNA and RNA Integrity by a Real-Time qPCR-Based Method.
Springer
Chapter
-
Bjørge, Monica Dahl;
Hildrestrand, Gunn Annette;
Scheffler, Katja;
Suganthan, Rajikala;
Rolseth, Veslemøy;
Kusnierczyk, Anna.
(2015)
Synergistic Actions of Ogg1 and Mutyh DNA Glycosylases Modulate Anxiety-like Behavior in Mice.
Cell reports
Academic article
2014
-
Strand, Janne Maren;
Skinnes, Ragnhild;
Scheffler, Katja;
Rootwelt, Terje;
Woldseth, Berit;
Bjørås, Magnar.
(2014)
Genome instability in Maple Syrup Urine Disease correlates with impaired mitochondrial biogenesis.
Metabolism: Clinical and Experimental
Academic article
-
Strand, Janne Maren;
Scheffler, Katja;
Bjørås, Magnar;
Eide, Lars.
(2014)
The distribution of DNA damage is defined by region-specific susceptibility to DNA damage formation rather than repair differences.
DNA Repair
Academic article
-
Wang, Wei;
Scheffler, Katja;
Esbensen, Qin Ying;
Strand, Janne Maren;
Stewart, James B.;
Bjørås, Magnar.
(2014)
Addressing RNA integrity to determine the impact of mitochondrial DNA mutations on brain mitochondrial function with age.
PLOS ONE
Academic article
-
Jalland, Clara;
Benestad, Sylvie Lafond;
Ersdal, Cecilie;
Scheffler, Katja;
Suganthan, Rajikala;
Nakabeppu, Yusaku.
(2014)
Accelerated clinical course of prion disease in mice compromised in repair of oxidative DNA damage.
Free Radical Biology & Medicine
Academic article
2012
-
Halsne, Ruth;
Esbensen, Qin Ying;
Wang, Wei;
Scheffler, Katja;
Suganthan, Rajikala;
Bjørås, Magnar.
(2012)
Lack of the DNA glycosylases MYH and OGG1 in the cancer prone double mutant mouse does not increase mitochondrial DNA mutagenesis.
DNA Repair
Academic article
Journal publications
-
Grøntvedt, Gøril Rolfseng;
Sando, Sigrid Botne;
Lauridsen, Camilla;
Bråthen, Geir;
White, Linda Rosemary;
Salvesen, Øyvind.
(2022)
Association of Klotho protein levels and KL-VS heterozygosity with Alzheimer disease and amyloid and tau burden.
JAMA Network Open
Academic article
-
Egiazarian, Milena Armenovna;
Strømstad, Silje;
Sakshaug, Teri;
Núñez Nescolarde, Ana Beatriz;
Bethge, Nicole;
Bjørås, Magnar.
(2022)
Age- and sex-dependent effects of DNA glycosylase Neil3 on amyloid pathology, adult neurogenesis, and memory in a mouse model of Alzheimer's disease.
Free Radical Biology & Medicine
Academic article
-
Tari, Atefe R;
Berg, Helene Haugen;
Videm, Vibeke;
Bråthen, Geir;
White, Linda Rosemary;
Røsbjørgen, Ragnhild.
(2022)
Safety and efficacy of plasma transfusion from exercise - trained donors in patients with early Alzheimer’s disease: protocol for the ExPlas study.
BMJ Open
Article in business/trade/industry journal
-
Hildrestrand, Gunn Annette;
Rolseth, Veslemøy;
Kunath, Nicolas;
Suganthan, Rajikala;
Jensen, Vidar;
Bugaj, Anna Maria.
(2021)
NEIL1 and NEIL2 DNA glycosylases modulate anxiety and learning in a cooperative manner in mice.
Communications Biology
Academic article
-
Sousa, Mirta;
Ye, Jing;
Gomez, Luisa Fernanda Luna;
Hildrestrand, Gunn Annette;
Bjørås, Karine;
Scheffler, Katja.
(2021)
Impact of oxidative DNA damage and the role of DNA glycosylases in neurological dysfunction.
International Journal of Molecular Sciences
Academic literature review
-
Quiles-Jiménez, Ana M T;
Gregersen, Ida;
Segers, Filip;
Skarpengland, Tonje;
Kroustallaki, Pinelopi;
Yang, Kuan.
(2021)
DNA glycosylase Neil3 regulates vascular smooth muscle cell biology during atherosclerosis development.
Atherosclerosis
Academic article
-
Farooq, Amna;
Grønmyr, Sindre;
Omer, Ali Avan;
Rognes, Torbjørn;
Scheffler, Katja;
Bjørås, Magnar.
(2020)
HMST-Seq-Analyzer: A new python tool for differential methylation and hydroxymethylation analysis in various DNA methylation sequencing data.
Computational and Structural Biotechnology Journal
Academic article
-
Scheffler, Katja;
Jalland, Clara Maria Osnes;
Benestad, Sylvie L.;
Moldal, Torfinn;
Ersdal, Cecilie;
Gunnes, Gjermund.
(2020)
DNA glycosylase Neil2 contributes to genomic responses in the spleen during clinical prion disease.
Free Radical Biology & Medicine
Academic article
-
Ystgaard, Martin Bogale;
Scheffler, Katja;
Suganthan, Rajikala;
Bjørås, Magnar;
Ranheim, Trine;
Sagen, Ellen Lund.
(2019)
Neuromodulatory effect of NLRP3 and ASC in neonatal hypoxic ischemic encephalopathy.
Neonatology
Academic article
-
Scheffler, Katja;
Bjørås, Karine Øian;
Bjørås, Magnar.
(2019)
Diverse functions of DNA glycosylases processing oxidative base lesions in brain.
DNA Repair
Academic literature review
-
Scheffler, Katja;
Rachek, Lyudmila;
You, Panpan;
Rowe, Alexander D.;
Wang, Wei;
Kuśnierczyk, Anna.
(2018)
8-oxoguanine DNA glycosylase (Ogg1) controls hepatic gluconeogenesis.
DNA Repair
Academic article
-
Olsen, Maria Belland;
Hildrestrand, Gunn Annette;
Scheffler, Katja;
Vinge, Leif Erik;
Alfsnes, Katrine;
Palibrk, Vuk.
(2017)
NEIL3-Dependent Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture.
Cell reports
Academic article
-
Rolseth, Veslemøy;
Gomez, Luisa Fernanda Luna;
Olsen, Ann-Karin;
Suganthan, Rajikala;
Scheffler, Katja;
Neurauter, Christine Gran.
(2017)
No cancer predisposition or increased spontaneous mutation frequencies in NEIL DNA glycosylases-deficient mice.
Scientific Reports
Academic article
-
Palibrk, Vuk;
Suganthan, Rajikala;
Scheffler, Katja;
Wang, Wei;
Bjørås, Magnar;
Bøe, Stig Ove.
(2016)
PML regulates neuroprotective innate immunity and neuroblast commitment in a hypoxic–ischemic encephalopathy model.
Cell Death & Disease
Academic article
-
Jalland, Clara Maria Osnes;
Scheffler, Katja;
Benestad, Sylvie Lafond;
Moldal, Torfinn;
Ersdal, Cecilie;
Gunnes, Gjermund.
(2016)
Neil3 induced neurogenesis protects against prion disease during the clinical phase.
Scientific Reports
Academic article
-
Skarpengland, Tonje;
Dahl, Tuva Børresdatter;
Skjelland, Mona;
Scheffler, Katja;
Sousa, Mirta;
Gregersen, Ida.
(2016)
Enhanced base excision repair capacity in carotid atherosclerosis may protect nuclear DNA but not mitochondrial DNA.
Free Radical Biology & Medicine
Academic article
-
Skarpengland, Tonje;
Holm, Sverre;
Scheffler, Katja;
Gregersen, Ida;
Dahl, Tuva Børresdatter;
Suganthan, Rajikala.
(2016)
Neil3-dependent base excision repair regulates lipid metabolism and prevents atherosclerosis in Apoe-deficient mice.
Scientific Reports
Academic article
-
Bjørge, Monica Dahl;
Hildrestrand, Gunn Annette;
Scheffler, Katja;
Suganthan, Rajikala;
Rolseth, Veslemøy;
Kusnierczyk, Anna.
(2015)
Synergistic Actions of Ogg1 and Mutyh DNA Glycosylases Modulate Anxiety-like Behavior in Mice.
Cell reports
Academic article
-
Strand, Janne Maren;
Skinnes, Ragnhild;
Scheffler, Katja;
Rootwelt, Terje;
Woldseth, Berit;
Bjørås, Magnar.
(2014)
Genome instability in Maple Syrup Urine Disease correlates with impaired mitochondrial biogenesis.
Metabolism: Clinical and Experimental
Academic article
-
Strand, Janne Maren;
Scheffler, Katja;
Bjørås, Magnar;
Eide, Lars.
(2014)
The distribution of DNA damage is defined by region-specific susceptibility to DNA damage formation rather than repair differences.
DNA Repair
Academic article
-
Wang, Wei;
Scheffler, Katja;
Esbensen, Qin Ying;
Strand, Janne Maren;
Stewart, James B.;
Bjørås, Magnar.
(2014)
Addressing RNA integrity to determine the impact of mitochondrial DNA mutations on brain mitochondrial function with age.
PLOS ONE
Academic article
-
Jalland, Clara;
Benestad, Sylvie Lafond;
Ersdal, Cecilie;
Scheffler, Katja;
Suganthan, Rajikala;
Nakabeppu, Yusaku.
(2014)
Accelerated clinical course of prion disease in mice compromised in repair of oxidative DNA damage.
Free Radical Biology & Medicine
Academic article
-
Halsne, Ruth;
Esbensen, Qin Ying;
Wang, Wei;
Scheffler, Katja;
Suganthan, Rajikala;
Bjørås, Magnar.
(2012)
Lack of the DNA glycosylases MYH and OGG1 in the cancer prone double mutant mouse does not increase mitochondrial DNA mutagenesis.
DNA Repair
Academic article
Part of book/report
-
Wang, Wei;
Scheffler, Katja;
Esbensen, Qin Ying;
Eide, Lars.
(2016)
Quantification of DNA Damage by Real-Time qPCR.
Springer
Chapter
-
Wang, Wei;
Esbensen, Qin Ying;
Scheffler, Katja;
Eide, Lars.
(2015)
Analysis of Mitochondrial DNA and RNA Integrity by a Real-Time qPCR-Based Method.
Springer
Chapter