TrønderBrain - Department of Neuroscience
The Trønderbrain project has been established in 2003 as a collaboration between the INB, NTNU and the Department of Neurology, St. Olavs Hospital to promote translational research on neurodegenerative diseases.
This heterogenous group of disorders is characterized by a progressive degeneration of brain structure and function. Common neurodegenerative diseases include Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS). The risk of being affected increases dramatically with age. With a steady increase of life expectancy, neurodegenerative diseases have become one of the biggest global health concerns among elderly.
The research focus of Trønderbrain is to understand molecular processes that drive the initiation and progression of neurodegenerative diseases with special emphasis on AD. The overall goal is to identify novel biomarkers for early diagnosis and targets for effective therapy. To achieve this, we have brought together a team of clinicians and research scientists to build the bridge from basic research in cell and animal models to clinical research in humans
Diagnosis of neurodegenerative diseases at an early stage still remains a challenge, thus methods to improve pre-symptomatic detection would provide opportunities for early intervention, treatment, and improved patient function.
We aim to identify novel biomarkers for neurodegenerative diseases by using advanced imaging technologies including 7T-MRI and PET-scanning as well as the promising liquid biopsy-based analysis of cell-free DNA and RNA. Further, investigating the underlying disease mechanisms will contribute to identify novel targets for diagnosis.
The underlying causes of neurodegenerative diseases are still mainly unknown. The pathogeneses are likely a result from complex interactions between genetic, epigenetic, and environmental factors preceding clinical manifestation of the diseases. Notably, no effective treatment to halt or reverse neurodegeneration is to date available. We aim to identify the molecular mechanisms underlying neurodegenerative diseases by combining state-of-the-art technologies including iPSC-reprogramming, direct neuronal conversion and generation of brain organoids from patient-derived blood cells with next-generation sequencing and functional neuroscience.
For our research we rely on volunteers that would like to participate in the project as healthy controls.
Do you still remember well?
Are between 55 and 80 years old?
Are you willing to return for follow-up visits after 2, 4 and 10 years?
Do you live in acceptable distance to St. Olavs Hospital?
Then, we ask you to carefully read the information about what your participation in our research would involve and get in contact with us.