Rapid Molecular Evaluation of Human Kidney Tissue Sections by In Situ Mass Spectrometry and Machine Learning to Classify the Nephrotic Syndrome
A rapid DESI-MS analysis on renal biopsies from 37 nephrotic syndrome (NS) patients identified lipid profiles for IgA nephropathy, membranous glomerulonephritis, and lupus nephritis. Using ML models, the method achieved 100% classification accuracy.