Background and activities

Postdoctoral Fellow at the Department of Physics, NTNU since December 2019 and part of the research group led by Prof. Kathrine Røe Redalen. Previous research carried out at Tuebingen University Hospital in the group of Prof. Daniela Thorwarth.

Research 

Our research activities are in the field of imaging guided radiotherapy of cancer. Imaging techniques such as PET and MR have great potential to identify cancer patients with tumor recurrence or persistence. PET and MR may also help to improve the radiotherapy treatment, for example through a more precise delineation of tumor versus normal tissue which can improve the planning of the radiation dose. Another example is that parameters can be derived from the images and be used to characterize the tumor in terms of its biology. This can help to determine radioresistant subregions in the tumor, which may be prognsotic for the response to therapy and serve as a target for a higher radiation dose. Such patient indivudal, imaging based treatment adaptation may in future help to achieve a better treatment outcome. Our research therefore addresses different aspects of integrating PET/MR imaging into radiotherapy:

  • Radiotherapy tailored imaging solutions for combined PET/MRI
  • New strategies to characterize tumors in terms of biology and radiation therapy resistance using multiparametric PET/MRI, machine learning methods and radiomics
  • Tumor control probability modelling and radiotherapy dose painting based on functional image data
  • Machine learning of functional image data for automatic tumor delineation
  • Optimization of radiotherapy specific imaging protocols for PET/MRI
  • Streamlining synthetic CT generation and PET attenuation correction

Current teaching

Awards/Grants

Memberships/Reviewing

 

Scientific, academic and artistic work

Displaying a selection of activities. See all publications in the database

2021

  • Bach-Gansmo, Nina; Sæther, Oddbjørn; Alsaker, Mirjam Delange; Redalen, Kathrine; Winter, René M.. (2021) Streamlining the use of PET/MRI in an MR-only radiotherapy workflow. NACP 2020/21 Symposium: Annual Meeting of the Nordic Association for Clinical Physics (NACP) ; digital. 2021-04-11 - 2021-04-13.
  • Knuth, Franziska Hanna; Adde, Ingvild Askim; Huynh, Bao Ngoc; Grøndahl, Aurora Rosvoll; Winter, René; Negård, Anne; Holmedal, Stein Harald; Meltzer, Sebastian; Ree, Anne Hansen; Flatmark, Kjersti; Dueland, Svein; Hole, Knut Håkon; Seierstad, Therese; Redalen, Kathrine; Futsæther, Cecilia Marie. (2021) MRI-based automatic segmentation of rectal cancer using 2D U-Net on two independent cohorts. BiGART2021 - ActaOncologica conference . ActaOncologica and DCCC Radiotherapy; Virtual event. 2021-10-06 - 2021-10-06.
  • Knuth, Franziska; Grøndahl, Aurora Rosvoll; Winter, René M.; Torheim, Turid Katrine Gjerstad; Negård, Anne; Holmedal, Stein Harald; Bakke, Kine Mari; Meltzer, Sebastian; Futsæther, Cecilia Marie; Redalen, Kathrine. (2021) Influence of functional MRI sequences on automatic segmentation of rectal cancer. NACP 2020/2021 symposium . Nordic Association for Clinical Physics; 2021-04-11 - 2021-04-13.
  • Winter, René M.; Bach-Gansmo, Nina; Sæther, Oddbjørn; Alsaker, Mirjam Delange; Redalen, Kathrine. (2021) PO-1666: Streamlining the use of PET/MRI in an MR-only radiotherapy workflow, Radiotherapy and Oncology, Volume 161, Supplement 1, 2021, Page S1389, ISSN 0167-8140. ESTRO 2021: Annual Meeting of the European Society for Radiation Therapy and Oncology (ESTRO) . ESTRO; Madrid. 2021-08-27 - 2021-08-31.
  • Winter, René M.; Julbø, Frida M. I.; Marthinsen, Anne Beate Langeland; Negård, Anne; Meltzer, Sebastian; Redalen, Kathrine; Malinen, Eirik. (2021) R2* MRI based dose painting by contours in rectal cancer (Talk). NACP 2020/21 Symposium: Annual Meeting of the Nordic Association for Clinical Physics (NACP) ; digital. 2021-04-11 - 2021-04-13.
  • Winter, René M.; Julbø, Frida M. I.; Marthinsen, Anne Beate Langeland; Negård, Anne; Meltzer, Sebastian; Redalen, Kathrine; Malinen, Eirik. (2021) R2* MRI based tumor control probability modelling for dose painting by contours in rectal cancer. Virtual 8th MR in RT Symposium 2021 in Heidelberg . German Cancer Research Center (DKFZ); Heidelberg. 2021-04-19 - 2021-04-21.
  • Wivilson, Linnea; Hernandez, Guillermo G.; Sæther, Oddbjørn; Redalen, Kathrine; Winter, René M.. (2021) PET attenuation correction for radiotherapy hardware components in combined PET/MRI. NACP 2020/21 Symposium: Annual Meeting of the Nordic Association for Clinical Physics (NACP) . NACP; digital. 2021-04-11 - 2021-04-13.
  • Winter, René. (2021) First experience with an RT tailored imaging setup on the combined PET/MR (Invited Talk). 180N Autumn Webinar . Norwegian Nuclear Medicine Consortium; Digital. 2021-10-01.
  • Winter, René. (2021) Streamlining the use of PET/MRI in an MR-only radiotherapy workflow (Invited Talk). Norwegian BiGART2021 . NIRO Network In Radiation Oncology; Oslo. 2021-10-05 - 2021-10-06.
  • Winter, René; Bach-Gansmo, Nina; Sæther, Oddbjørn; Alsaker, Mirjam Delange; Redalen, Kathrine. (2021) Streamlining the use of PET/MRI in an MR-only radiotherapy workflow. BiGART2021 - ActaOncologica conference . ActaOncologica and Danish Comprehensive Cancer Center (DCCC); Virtual Symposia. 2021-10-06.

2020

2019

  • Winter, René M.. (2019) Multi-parametric functional imaging for personalized RT adaptations (Invited Talk). 50th Annual Meeting of the German Society for Medical Physics (DGMP) ; Stuttgart, Germany. 2019-09-18 - 2019-09-21.
  • Winter, René M.; Leibfarth, Sara; Boeke, Simon; Mena-Romano, Pamela; Krueger, Marcel; Cumhur Sezgin, Efe; Bowden, Gregory; Cotton, Jonathan; Pichler, Bernd J.; Zips, Daniel; Thorwarth, Daniela. (2019) EP-2029: Principal component analysis for quantitative and robust analysis of dynamic PET/MR imaging data, Radiotherapy and Oncology, Volume 133, Supplement 1, 2019, Pages S1113-S1114, ISSN 0167-8140. ESTRO 38: 38th Annual Meeting of the European Society for Radiotherapy and Oncology (ESTRO) ; Milan. 2019-04-26 - 2019-09-30.
  • Winter, René M.; Leibfarth, Sara; Boeke, Simon; Mena-Romano, Pamela; Krueger, Marcel; Cumhur Sezgin, Efe; Bowden, Gregory; Cotton, Jonathan; Pichler, Bernd J.; Zips, Daniel; Thorwarth, Daniela. (2019) Prediction of dynamic FMISO-PET voxel information by multi-parametric MRI features (Talk). 50th Annual Meeting of the German Society for Medical Physics (DGMP) ; Stuttgart, Germany. 2019-09-18 - 2019-09-21.

2018

2017

  • Winter, René M.; Boeke, Simon; Krueger, Marcel; Menegakis, Apostolos; Cumhur Sezgin, Efe; Wack, Linda; Reischl, Gerald; Pichler, Bernd J.; Zips, Daniel; Thorwarth, Daniela. (2017) Voxelbased analysis of FMISO-PET and diffusion-weighted MRI of two different HNSCC models in mice (Poster EP-1688). ESTRO 36: 36th Annual Meeting of the European Society for Radiotherapy and Oncology (ESTRO) ; Vienna. 2017-05-05 - 2017-05-09.
  • Winter, René M.; Schmidt, Holger; Leibfarth, Sara; Zwirner, Kerstin; Welz, Stefan; Schwenzer, Nina F.; La Fougère, Christian; Nikolaou, Konstantin; Gatidis, Sergios; Zips, Daniel; Thorwarth, Daniela. (2017) Distortion correction of diffusion-weighted magnetic resonance imaging of the head and neck in radiotherapy position. Acta Oncologica. vol. 56 (11).
  • Winter, René M.; Schmidt, Holger; Leibfarth, Sara; Zwirner, Kerstin; Welz, Stefan; Schwenzer, Nina F.; La Fougère, Christian; Nikolaou, Konstantin; Gatidis, Sergios; Zips, Daniel; Thorwarth, Daniela. (2017) Hardware solution for simultaneous PET/MRI in radiotherapy treatment position: diffusion-weighted imaging in head and neck cancer (Poster). BiGART 2017: 15th Acta Oncologica conference on Biology-Guided Adaptive Radiotherapy (BiGART) ; Aarhus. 2017-06-14 - 2017-06-16.

2016

  • Winter, René M.; Boeke, Simon; Krueger, Marcel; Stegen, Benjamin; Menegakis, Apostolos; Wack, Linda; Zips, Daniel; Thorwarth, Daniela. (2016) Integrated PET/MR imaging of tumor response to fractionated irradiation in xenograft models of human HNSCC - a feasibility study (Poster). Congress of the Center for Personalized Medicine (ZPM) Tuebingen ; Tuebingen, Germany. 2016-05-18 - 2016-05-20.
  • Winter, René M.; Leibfarth, Sara; Schmidt, Holger; Schwenzer, Nina F.; Zips, Daniel; Thorwarth, Daniela. (2016) Evaluation der Bildgebungseigenschaften einer Hardwareloesung fuer strahlentherapiespezifische Patientenlagerung in der PET/MR Bildgebung (Talk). 22nd Annual Meeting of the German Society for Radiation Oncology (DEGRO) ; Mannheim, Germany. 2016-06-16 - 2016-06-19.
  • Winter, René M.; Leibfarth, Sara; Schmidt, Holger; Schwenzer, Nina F.; Zips, Daniel; Thorwarth, Daniela. (2016) Evaluation of diffusion-weighted imaging properties of a RT-specific positioning solution for PET/MR imaging (Poster EP-1910). ESTRO 35: 35th Annual Meeting of the European Society for Radiotherapy and Oncology (ESTRO) ; Turin. 2016-04-29 - 2016-05-03.

2015

  • Winter, René M.; Leibfarth, Sara; Gatidis, Sergios; Schmidt, Holger; Schwenzer, Nina F.; Zips, Daniel; Thorwarth, Daniela. (2015) Evaluation of imaging properties of a dedicated RT positioning solution for combined PET/MR imaging (Poster PD-0454, Poster Award). 3rd ESTRO Forum, Annual Meeting of the European Society for Radiotherapy and Oncology (ESTRO) ; Barcelona. 2015-04-24 - 2015-04-28.
  • Winter, René M.; Leibfarth, Sara; Gatidis, Sergios; Schmidt, Holger; Schwenzer, Nina F.; Zips, Daniel; Thorwarth, Daniela. (2015) Prototype hardware solution to allow for RT-specific positioning of HN cancer patients during PET/MR imaging - Evaluation of imaging properties (Poster). EMIM 2015: European Molecular Imaging Meeting (EMIM), the 10th Annual Meeting of the European Society for Molecular Imaging (ESMI) ; Tuebingen, Germany. 2015-03-18 - 2015-03-20.

2014

  • Winter, René M.; Leibfarth, Sara; Paulus, Daniel H.; Quick, Harald H.; Gatidis, Sergios; Schmidt, Holger; Schwenzer, Nina F.; Zips, Daniel; Thorwarth, Daniela. (2014) Evaluation of a dedicated radiotherapy positioning solution for combined PET/MR imaging (Talk). ESTRO 33: 33rd Annual Meeting of the European Society for Radiotherapy and Oncology (ESTRO) ; Vienna. 2014-04-04 - 2014-04-08.