René Winter
+4773592045
Realfagbygget, B4-139, Gløshaugen, Høgskoleringen 5
About
Postdoctoral Fellow at the Department of Physics, NTNU since December 2019 and part of the research group led by Prof. Kathrine Røe Redalen. Previous research carried out at Tuebingen University Hospital in the group of Prof. Daniela Thorwarth.
Research
Our research activities are in the field of imaging guided radiotherapy of cancer. Imaging techniques such as PET and MR have great potential to identify cancer patients with tumor recurrence or persistence. PET and MR may also help to improve the radiotherapy treatment, for example through a more precise delineation of tumor versus normal tissue which can improve the planning of the radiation dose. Another example is that parameters can be derived from the images and be used to characterize the tumor in terms of its biology. This can help to determine radioresistant subregions in the tumor, which may be prognsotic for the response to therapy and serve as a target for a higher radiation dose. Such patient indivudal, imaging based treatment adaptation may in future help to achieve a better treatment outcome. Our research therefore addresses different aspects of integrating PET/MR imaging into radiotherapy:
- Radiotherapy tailored imaging solutions for combined PET/MRI
- New strategies to characterize tumors in terms of biology and radiation therapy resistance using multiparametric PET/MRI, machine learning methods and radiomics
- Tumor control probability modelling and radiotherapy dose painting based on functional image data
- Machine learning of functional image data for automatic tumor delineation
- Optimization of radiotherapy specific imaging protocols for PET/MRI
- Streamlining synthetic CT generation and PET attenuation correction
Current teaching
- Physics of Medical Imaging TFY4320, Exercises spring 2022
Awards/Grants
- Research stay grants by the Norwegian Nuclear Medicine Consortium, 2021 and 2022
- ESTRO Jack Fowler Award, Vienna 2020
- ESTRO Poster Award, Barcelona 2015
Other activities
- Member of ESTRO and EANM
- Reviews for Radiother Oncol, EJNMMI, Med Phys, EJMP, phiRO, QIMS, ESTRO
- External sensor at the Norwegian University of Life Sciences, NMBU
Publications
2022
-
Knuth, Franziska Hanna;
Grøndahl, Aurora Rosvoll;
Winter, René;
Torheim, Turid Katrine Gjerstad;
Negård, Anne;
Holmedal, Stein Harald;
Bakke, Kine Mari;
Meltzer, Sebastian;
Futsæther, Cecilia Marie;
Redalen, Kathrine.
(2022)
Semi-automatic tumor segmentation of rectal cancer based on functional magnetic resonance imaging.
Physics and imaging in radiation oncology (PIRO).
volum 22.
Academic article
2021
-
Knuth, Franziska Hanna;
Adde, Ingvild Askim;
Huynh, Bao Ngoc;
Grøndahl, Aurora Rosvoll;
Winter, René;
Negård, Anne;
Holmedal, Stein Harald;
Meltzer, Sebastian;
Ree, Anne Hansen;
Flatmark, Kjersti;
Dueland, Svein;
Hole, Knut Håkon;
Seierstad, Therese;
Redalen, Kathrine;
Futsæther, Cecilia Marie.
(2021)
MRI-based automatic segmentation of rectal cancer using 2D U-Net on two independent cohorts.
Acta Oncologica.
volum 61 (2).
Academic article
2020
-
Clasen, Kerstin;
Leibfarth, Sara;
Hilke, Franz J.;
Admard, Jakob;
Winter, René M.;
Welz, Stefan;
Gatidis, Sergios;
Nann, Dominik;
Ossowski, Stephan;
Breuer, Thomas;
La Fougère, Christian;
Nikolaou, Konstantin;
Riess, Olaf;
Zips, Daniel;
Schroeder, Christopher;
Thorwarth, Daniela.
(2020)
PET/MRI and genetic intrapatient heterogeneity in head and neck cancers.
Strahlentherapie und Onkologie (Print).
Academic article
-
Böke, Simon;
Winter, René;
Nachbar, Marcel;
Clasen, Kerstin;
Gani, Cihan;
Stolte, A;
Boldt, J;
Marks, Claudia;
Gatidis, Sergios;
Nikolaou, Konstantin;
Zips, Daniel;
Thorwarth, Daniela.
(2020)
PO-1685 Serial DWI in HNC treated on a 1.5 T MRLinac and benchmark to a reference 3 T diagnostic MR scanner.
Radiotherapy and Oncology.
volum 152.
Summary/Abstract
2018
-
Thorwarth, Daniela;
Zwirner, Kerstin;
Winter, René M.;
Welz, Stefan;
Zips, Daniel;
Gatidis, Sergios;
Weiß, Jakob;
Nikolaou, Konstantin.
(2018)
MR-simulation for radiotherapy treatment planning of head and neck cancer using 3T MAGNETOM Vida.
MReadings: MR in RT.
volum 4.
Article
-
Winter, René M.;
Leibfarth, Sara;
Schmidt, Holger;
Zwirner, Kerstin;
Moennich, David;
Welz, Stefan;
Schwenzer, Nina F.;
La Fougère, Christian;
Nikolaou, Konstantin;
Gatidis, Sergios;
Zips, Daniel;
Thorwarth, Daniela.
(2018)
Assessment of image quality of a radiotherapy-specific hardware solution for PET/MRI in head and neck cancer patients.
Radiotherapy and Oncology.
volum 128 (3).
Academic article
-
Zwirner, Kerstin;
Thorwarth, Daniela;
Winter, René M.;
Welz, Stefan;
Weiss, Jakob;
Schwenzer, Nina F.;
Schmidt, Holger;
La Fougère, Christian;
Nikolaou, Konstantin;
Zips, Daniel;
Gatidis, Sergios.
(2018)
Voxel-wise correlation of functional imaging parameters in HNSCC patients receiving PET/MRI in an irradiation setup.
Strahlentherapie und Onkologie (Print).
volum 194 (8).
Academic article
-
Leibfarth, Sara;
Winter, René M.;
Lyng, Heidi;
Zips, Daniel;
Thorwarth, Daniela.
(2018)
Potentials and challenges of diffusion-weighted magnetic resonance imaging in radiotherapy.
Clinical and Translational Radiation Oncology.
volum 13.
Academic article
2017
-
Winter, René M.;
Schmidt, Holger;
Leibfarth, Sara;
Zwirner, Kerstin;
Welz, Stefan;
Schwenzer, Nina F.;
La Fougère, Christian;
Nikolaou, Konstantin;
Gatidis, Sergios;
Zips, Daniel;
Thorwarth, Daniela.
(2017)
Distortion correction of diffusion-weighted magnetic resonance imaging of the head and neck in radiotherapy position.
Acta Oncologica.
volum 56 (11).
Letter to the editor
Scientific articles
-
Knuth, Franziska Hanna;
Grøndahl, Aurora Rosvoll;
Winter, René;
Torheim, Turid Katrine Gjerstad;
Negård, Anne;
Holmedal, Stein Harald;
Bakke, Kine Mari;
Meltzer, Sebastian;
Futsæther, Cecilia Marie;
Redalen, Kathrine.
(2022)
Semi-automatic tumor segmentation of rectal cancer based on functional magnetic resonance imaging.
Physics and imaging in radiation oncology (PIRO).
volum 22.
Academic article
-
Knuth, Franziska Hanna;
Adde, Ingvild Askim;
Huynh, Bao Ngoc;
Grøndahl, Aurora Rosvoll;
Winter, René;
Negård, Anne;
Holmedal, Stein Harald;
Meltzer, Sebastian;
Ree, Anne Hansen;
Flatmark, Kjersti;
Dueland, Svein;
Hole, Knut Håkon;
Seierstad, Therese;
Redalen, Kathrine;
Futsæther, Cecilia Marie.
(2021)
MRI-based automatic segmentation of rectal cancer using 2D U-Net on two independent cohorts.
Acta Oncologica.
volum 61 (2).
Academic article
-
Clasen, Kerstin;
Leibfarth, Sara;
Hilke, Franz J.;
Admard, Jakob;
Winter, René M.;
Welz, Stefan;
Gatidis, Sergios;
Nann, Dominik;
Ossowski, Stephan;
Breuer, Thomas;
La Fougère, Christian;
Nikolaou, Konstantin;
Riess, Olaf;
Zips, Daniel;
Schroeder, Christopher;
Thorwarth, Daniela.
(2020)
PET/MRI and genetic intrapatient heterogeneity in head and neck cancers.
Strahlentherapie und Onkologie (Print).
Academic article
-
Winter, René M.;
Leibfarth, Sara;
Schmidt, Holger;
Zwirner, Kerstin;
Moennich, David;
Welz, Stefan;
Schwenzer, Nina F.;
La Fougère, Christian;
Nikolaou, Konstantin;
Gatidis, Sergios;
Zips, Daniel;
Thorwarth, Daniela.
(2018)
Assessment of image quality of a radiotherapy-specific hardware solution for PET/MRI in head and neck cancer patients.
Radiotherapy and Oncology.
volum 128 (3).
Academic article
-
Zwirner, Kerstin;
Thorwarth, Daniela;
Winter, René M.;
Welz, Stefan;
Weiss, Jakob;
Schwenzer, Nina F.;
Schmidt, Holger;
La Fougère, Christian;
Nikolaou, Konstantin;
Zips, Daniel;
Gatidis, Sergios.
(2018)
Voxel-wise correlation of functional imaging parameters in HNSCC patients receiving PET/MRI in an irradiation setup.
Strahlentherapie und Onkologie (Print).
volum 194 (8).
Academic article
-
Leibfarth, Sara;
Winter, René M.;
Lyng, Heidi;
Zips, Daniel;
Thorwarth, Daniela.
(2018)
Potentials and challenges of diffusion-weighted magnetic resonance imaging in radiotherapy.
Clinical and Translational Radiation Oncology.
volum 13.
Academic article
Journal publications
-
Böke, Simon;
Winter, René;
Nachbar, Marcel;
Clasen, Kerstin;
Gani, Cihan;
Stolte, A;
Boldt, J;
Marks, Claudia;
Gatidis, Sergios;
Nikolaou, Konstantin;
Zips, Daniel;
Thorwarth, Daniela.
(2020)
PO-1685 Serial DWI in HNC treated on a 1.5 T MRLinac and benchmark to a reference 3 T diagnostic MR scanner.
Radiotherapy and Oncology.
volum 152.
Summary/Abstract
-
Thorwarth, Daniela;
Zwirner, Kerstin;
Winter, René M.;
Welz, Stefan;
Zips, Daniel;
Gatidis, Sergios;
Weiß, Jakob;
Nikolaou, Konstantin.
(2018)
MR-simulation for radiotherapy treatment planning of head and neck cancer using 3T MAGNETOM Vida.
MReadings: MR in RT.
volum 4.
Article
-
Winter, René M.;
Schmidt, Holger;
Leibfarth, Sara;
Zwirner, Kerstin;
Welz, Stefan;
Schwenzer, Nina F.;
La Fougère, Christian;
Nikolaou, Konstantin;
Gatidis, Sergios;
Zips, Daniel;
Thorwarth, Daniela.
(2017)
Distortion correction of diffusion-weighted magnetic resonance imaging of the head and neck in radiotherapy position.
Acta Oncologica.
volum 56 (11).
Letter to the editor
Media
2022
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PosterBratting, Ole Jakob; Lium, Maren; Sæther, Oddbjørn; Engelsen, Ola; Redalen, Kathrine; Winter, René. (2022) O02 Multicenter diffusion-weighted MRI on a hybrid PET/MR with a radiotherapy setup: phantom studies (poster presentation). 180N Conference Tromsø . Norwegian Nuclear Medicine Consortium; Tromsø. 2022-03-29 - 2022-03-31.
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LectureLium, Maren; Sæther, Oddbjørn; Engelsen, Ola; Redalen, Kathrine; Winter, René. (2022) Quality assurance of multicenter diffusion-weighted MRI on a hybrid PET/MR with a radiotherapy setup (talk). MEDFYS 2022 . Norsk Forening for Medisinsk Fysikk; Hurdal. 2022-05-23 - 2022-05-25.
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LectureWinter, René. (2022) Erfaringer fra bruk av MR i stråleterapi (invited talk). MEDFYS 2022 . Norsk Forening for Medisinsk Fysikk; Hurdal. 2022-05-23 - 2022-05-25.
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LectureWinter, René; Bratting, Ole Jakob; Lium, Maren; Brekke, Njål; Sæterstøl, Jostein; Engelsen, Ola; Sæther, Oddbjørn; Redalen, Kathrine. (2022) Image quality assessment for quantitative radiotherapy-tailored PET/MR in multicenter trials: a phantom study. Biophysics and Medical Physics Spring Meeting 2022 ; Trondheim. 2022-05-12 - 2022-05-13.
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PosterWinter, René; Bratting, Ole Jakob; Lium, Maren; Brekke, Njål; Sæther, Oddbjørn; Engelsen, Ola; Redalen, Kathrine. (2022) PO-1656 Accuracy of diffusion-weighted MRI in radiotherapy setup for multicenter PET/MRI in head/neck cancer. ESTRO 2022 ; Copenhagen. 2022-05-06 - 2022-05-10.
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PosterWinter, René; Engelsen, Ola; Sæterstøl, Jostein; Sæther, Oddbjørn; Redalen, Kathrine. (2022) PO-1653 Reproducibility of quantitative PET in radiotherapy setup for multicenter PET/MR in head/neck cancer. ESTRO 2022 ; Copenhagen. 2022-05-06 - 2022-05-10.
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Academic lectureWinter, René; Engelsen, Ola; Sæther, Oddbjørn; Redalen, Kathrine. (2022) OP-567 PET image quality assessment for quantitative radiotherapy-tailored PET/MR in multicenter trials: a phantom study. EANM 2022 . European Association of Nuclear Medicine; Barcelona. 2022-10-15 - 2022-10-19.
2021
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PosterBach-Gansmo, Nina; Sæther, Oddbjørn; Alsaker, Mirjam Delange; Redalen, Kathrine; Winter, René M.. (2021) Streamlining the use of PET/MRI in an MR-only radiotherapy workflow. NACP 2020/21 Symposium: Annual Meeting of the Nordic Association for Clinical Physics (NACP) ; digital. 2021-04-11 - 2021-04-13.
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PosterWinter, René M.; Bach-Gansmo, Nina; Sæther, Oddbjørn; Alsaker, Mirjam Delange; Redalen, Kathrine. (2021) PO-1666: Streamlining the use of PET/MRI in an MR-only radiotherapy workflow, Radiotherapy and Oncology, Volume 161, Supplement 1, 2021, Page S1389, ISSN 0167-8140. ESTRO 2021: Annual Meeting of the European Society for Radiation Therapy and Oncology (ESTRO) . ESTRO; Madrid. 2021-08-27 - 2021-08-31.
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Academic lectureWinter, René M.; Julbø, Frida M. I.; Marthinsen, Anne Beate Langeland; Negård, Anne; Meltzer, Sebastian; Redalen, Kathrine; Malinen, Eirik. (2021) R2* MRI based dose painting by contours in rectal cancer (Talk). NACP 2020/21 Symposium: Annual Meeting of the Nordic Association for Clinical Physics (NACP) ; digital. 2021-04-11 - 2021-04-13.
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Academic lectureWinter, René M.; Julbø, Frida M. I.; Marthinsen, Anne Beate Langeland; Negård, Anne; Meltzer, Sebastian; Redalen, Kathrine; Malinen, Eirik. (2021) R2* MRI based tumor control probability modelling for dose painting by contours in rectal cancer. Virtual 8th MR in RT Symposium 2021 in Heidelberg . German Cancer Research Center (DKFZ); Heidelberg. 2021-04-19 - 2021-04-21.
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Academic lectureWivilson, Linnea; Hernandez, Guillermo G.; Sæther, Oddbjørn; Redalen, Kathrine; Winter, René M.. (2021) PET attenuation correction for radiotherapy hardware components in combined PET/MRI. NACP 2020/21 Symposium: Annual Meeting of the Nordic Association for Clinical Physics (NACP) . NACP; digital. 2021-04-11 - 2021-04-13.
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Academic lectureWinter, René. (2021) First experience with an RT tailored imaging setup on the combined PET/MR (Invited Talk). 180N Autumn Webinar . Norwegian Nuclear Medicine Consortium; Digital. 2021-10-01.
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Academic lectureWinter, René. (2021) Streamlining the use of PET/MRI in an MR-only radiotherapy workflow (Invited Talk). Norwegian BiGART2021 . NIRO Network In Radiation Oncology; Oslo. 2021-10-05 - 2021-10-06.
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PosterWinter, René; Bach-Gansmo, Nina; Sæther, Oddbjørn; Alsaker, Mirjam Delange; Redalen, Kathrine. (2021) Streamlining the use of PET/MRI in an MR-only radiotherapy workflow. BiGART2021 - ActaOncologica conference . ActaOncologica and Danish Comprehensive Cancer Center (DCCC); Virtual Symposia. 2021-10-06.
2020
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Academic lectureWinter, René M.; Leibfarth, Sara; Boeke, Simon; Krueger, Marcel; Mena-Romano, Pamela; Cumhur Sezgin, Efe; Bowden, Gregory; Cotton, Jonathan; Pichler, Bernd J.; Zips, Daniel; Thorwarth, Daniela. (2020) OC-0584: Intratumoral prediction of dynamic FMISO-PET information by machine learning of multi-parametric MRI. Radiotherapy and Oncology, Volume 152, Supplement 1, 2020, Page S328, ISSN 0167-8140, https://doi.org/10.1016/S0167-8140(21)00606-X. ESTRO 2020: 39th Annual Meeting of the European Society for Radiation Therapy and Oncology (ESTRO) ; Vienna/digital. 2020-11-28 - 2020-12-01.
2019
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Academic lectureWinter, René M.. (2019) Multi-parametric functional imaging for personalized RT adaptations (Invited Talk). 50th Annual Meeting of the German Society for Medical Physics (DGMP) ; Stuttgart, Germany. 2019-09-18 - 2019-09-21.
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PosterWinter, René M.; Leibfarth, Sara; Boeke, Simon; Mena-Romano, Pamela; Krueger, Marcel; Cumhur Sezgin, Efe; Bowden, Gregory; Cotton, Jonathan; Pichler, Bernd J.; Zips, Daniel; Thorwarth, Daniela. (2019) EP-2029: Principal component analysis for quantitative and robust analysis of dynamic PET/MR imaging data, Radiotherapy and Oncology, Volume 133, Supplement 1, 2019, Pages S1113-S1114, ISSN 0167-8140. ESTRO 38: 38th Annual Meeting of the European Society for Radiotherapy and Oncology (ESTRO) ; Milan. 2019-04-26 - 2019-09-30.
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Academic lectureWinter, René M.; Leibfarth, Sara; Boeke, Simon; Mena-Romano, Pamela; Krueger, Marcel; Cumhur Sezgin, Efe; Bowden, Gregory; Cotton, Jonathan; Pichler, Bernd J.; Zips, Daniel; Thorwarth, Daniela. (2019) Prediction of dynamic FMISO-PET voxel information by multi-parametric MRI features (Talk). 50th Annual Meeting of the German Society for Medical Physics (DGMP) ; Stuttgart, Germany. 2019-09-18 - 2019-09-21.
2018
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Academic lectureWinter, René M.. (2018) Image quality assessment of a dedicated hardware setup for PET/MRI in radiotherapy treatment position (Invited Talk). Medical Physics Colloquium of the German Cancer Research Center (DKFZ) ; Heidelberg, Germany. 2018-11-07.
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Academic lectureWinter, René M.. (2018) PCA for robust analysis of dynamic PET/MR imaging data (Talk). 2nd ESTRO Physics Workshop on Quantitative Imaging by the European Society for Radiotherapy and Oncology (ESTRO) ; Malaga. 2018-10-26 - 2018-10-27.
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Academic lectureWinter, René M.; Leibfarth, Sara; Zwirner, Kerstin; Schmidt, Holger; Welz, Stefan; Schwenzer, Nina F.; La Fougère, Christian; Nikolaou, Konstantin; Gatidis, Sergios; Zips, Daniel; Thorwarth, Daniela. (2018) Image quality assessment of a dedicated hardware setup for simultaneous PET/MRI in radiotherapy treatment position (Talk). 49th Annual Meeting of the German Society for Medical Physics (DGMP) - 21st Annual Meeting of the German Chapter of the International Society for Magnetic Resonance in Medicine (ISMRM) ; Nuremberg, Germany. 2018-09-19 - 2018-09-22.
2017
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PosterWinter, René M.; Boeke, Simon; Krueger, Marcel; Menegakis, Apostolos; Cumhur Sezgin, Efe; Wack, Linda; Reischl, Gerald; Pichler, Bernd J.; Zips, Daniel; Thorwarth, Daniela. (2017) EP-1688 Voxelbased analysis of FMISO-PET and diffusion-weighted MRI of two different HNSCC models in mice. ESTRO 36: 36th Annual Meeting of the European Society for Radiotherapy and Oncology (ESTRO) ; Vienna. 2017-05-05 - 2017-05-09.
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PosterWinter, René M.; Schmidt, Holger; Leibfarth, Sara; Zwirner, Kerstin; Welz, Stefan; Schwenzer, Nina F.; La Fougère, Christian; Nikolaou, Konstantin; Gatidis, Sergios; Zips, Daniel; Thorwarth, Daniela. (2017) Hardware solution for simultaneous PET/MRI in radiotherapy treatment position: diffusion-weighted imaging in head and neck cancer (Poster). BiGART 2017: 15th Acta Oncologica conference on Biology-Guided Adaptive Radiotherapy (BiGART) ; Aarhus. 2017-06-14 - 2017-06-16.
2016
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PosterWinter, René M.; Boeke, Simon; Krueger, Marcel; Stegen, Benjamin; Menegakis, Apostolos; Wack, Linda; Zips, Daniel; Thorwarth, Daniela. (2016) Integrated PET/MR imaging of tumor response to fractionated irradiation in xenograft models of human HNSCC - a feasibility study (Poster). Congress of the Center for Personalized Medicine (ZPM) Tuebingen ; Tuebingen, Germany. 2016-05-18 - 2016-05-20.
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PosterWinter, René M.; Leibfarth, Sara; Schmidt, Holger; Schwenzer, Nina F.; Zips, Daniel; Thorwarth, Daniela. (2016) EP-1910 Evaluation of diffusion-weighted imaging properties of a RT-specific positioning solution for PET/MR imaging. ESTRO 35: 35th Annual Meeting of the European Society for Radiotherapy and Oncology (ESTRO) ; Turin. 2016-04-29 - 2016-05-03.
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Academic lectureWinter, René M.; Leibfarth, Sara; Schmidt, Holger; Schwenzer, Nina F.; Zips, Daniel; Thorwarth, Daniela. (2016) V05-2 Evaluation der Bildgebungseigenschaften einer Hardwareloesung fuer strahlentherapiespezifische Patientenlagerung in der PET/MR Bildgebung. 22nd Annual Meeting of the German Society for Radiation Oncology (DEGRO) ; Mannheim, Germany. 2016-06-16 - 2016-06-19.
2015
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PosterWinter, René M.; Leibfarth, Sara; Gatidis, Sergios; Schmidt, Holger; Schwenzer, Nina F.; Zips, Daniel; Thorwarth, Daniela. (2015) PD-0454 Evaluation of imaging properties of a dedicated RT positioning solution for combined PET/MR imaging. 3rd ESTRO Forum, Annual Meeting of the European Society for Radiotherapy and Oncology (ESTRO) ; Barcelona. 2015-04-24 - 2015-04-28.
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PosterWinter, René M.; Leibfarth, Sara; Gatidis, Sergios; Schmidt, Holger; Schwenzer, Nina F.; Zips, Daniel; Thorwarth, Daniela. (2015) Prototype hardware solution to allow for RT-specific positioning of HN cancer patients during PET/MR imaging - Evaluation of imaging properties (Poster). EMIM 2015: European Molecular Imaging Meeting (EMIM), the 10th Annual Meeting of the European Society for Molecular Imaging (ESMI) ; Tuebingen, Germany. 2015-03-18 - 2015-03-20.
2014
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Academic lectureWinter, René M.; Leibfarth, Sara; Paulus, Daniel H.; Quick, Harald H.; Gatidis, Sergios; Schmidt, Holger; Schwenzer, Nina F.; Zips, Daniel; Thorwarth, Daniela. (2014) OC-0083 Evaluation of a dedicated radiotherapy positioning solution for combined PET/MR imaging. ESTRO 33: 33rd Annual Meeting of the European Society for Radiotherapy and Oncology (ESTRO) ; Vienna. 2014-04-04 - 2014-04-08.