René Winter
Background and activities
Postdoctoral Fellow at the Department of Physics, NTNU since December 2019 and part of the research group led by Prof. Kathrine Røe Redalen. Previous research carried out at Tuebingen University Hospital in the group of Prof. Daniela Thorwarth.
Research
Our research activities are in the field of imaging guided radiotherapy of cancer. Imaging techniques such as PET and MR have great potential to identify cancer patients with tumor recurrence or persistence. PET and MR may also help to improve the radiotherapy treatment, for example through a more precise delineation of tumor versus normal tissue which can improve the planning of the radiation dose. Another example is that parameters can be derived from the images and be used to characterize the tumor in terms of its biology. This can help to determine radioresistant subregions in the tumor, which may be prognsotic for the response to therapy and serve as a target for a higher radiation dose. Such patient indivudal, imaging based treatment adaptation may in future help to achieve a better treatment outcome. Our research therefore addresses different aspects of integrating PET/MR imaging into radiotherapy:
- Radiotherapy tailored imaging solutions for combined PET/MRI
- New strategies to characterize tumors in terms of biology and radiation therapy resistance using multiparametric PET/MRI, machine learning methods and radiomics
- Tumor control probability modelling and radiotherapy dose painting based on functional image data
- Machine learning of functional image data for automatic tumor delineation
- Optimization of radiotherapy specific imaging protocols for PET/MRI
- Streamlining synthetic CT generation and PET attenuation correction
Current teaching
- Physics of Medical Imaging TFY4320, Exercises spring 2022
Awards/Grants
- Travel grant by the Norwegian Nuclear Medicine Consortium, 2021
- ESTRO Jack Fowler Award, Vienna 2020
- ESTRO Poster Award, Barcelona 2015
Memberships/Reviewing
- Member of ESTRO
- Reviewer for Radiother Oncol, EJMP and phiRO
Scientific, academic and artistic work
Displaying a selection of activities. See all publications in the database
2021
- (2021) Streamlining the use of PET/MRI in an MR-only radiotherapy workflow. NACP 2020/21 Symposium: Annual Meeting of the Nordic Association for Clinical Physics (NACP) ; digital. 2021-04-11 - 2021-04-13.
- (2021) MRI-based automatic segmentation of rectal cancer using 2D U-Net on two independent cohorts. BiGART2021 - ActaOncologica conference . ActaOncologica and DCCC Radiotherapy; Virtual event. 2021-10-06 - 2021-10-06.
- (2021) Influence of functional MRI sequences on automatic segmentation of rectal cancer. NACP 2020/2021 symposium . Nordic Association for Clinical Physics; 2021-04-11 - 2021-04-13.
- (2021) PO-1666: Streamlining the use of PET/MRI in an MR-only radiotherapy workflow, Radiotherapy and Oncology, Volume 161, Supplement 1, 2021, Page S1389, ISSN 0167-8140. ESTRO 2021: Annual Meeting of the European Society for Radiation Therapy and Oncology (ESTRO) . ESTRO; Madrid. 2021-08-27 - 2021-08-31.
- (2021) R2* MRI based dose painting by contours in rectal cancer (Talk). NACP 2020/21 Symposium: Annual Meeting of the Nordic Association for Clinical Physics (NACP) ; digital. 2021-04-11 - 2021-04-13.
- (2021) R2* MRI based tumor control probability modelling for dose painting by contours in rectal cancer. Virtual 8th MR in RT Symposium 2021 in Heidelberg . German Cancer Research Center (DKFZ); Heidelberg. 2021-04-19 - 2021-04-21.
- (2021) PET attenuation correction for radiotherapy hardware components in combined PET/MRI. NACP 2020/21 Symposium: Annual Meeting of the Nordic Association for Clinical Physics (NACP) . NACP; digital. 2021-04-11 - 2021-04-13.
- (2021) First experience with an RT tailored imaging setup on the combined PET/MR (Invited Talk). 180N Autumn Webinar . Norwegian Nuclear Medicine Consortium; Digital. 2021-10-01.
- (2021) Streamlining the use of PET/MRI in an MR-only radiotherapy workflow (Invited Talk). Norwegian BiGART2021 . NIRO Network In Radiation Oncology; Oslo. 2021-10-05 - 2021-10-06.
- (2021) Streamlining the use of PET/MRI in an MR-only radiotherapy workflow. BiGART2021 - ActaOncologica conference . ActaOncologica and Danish Comprehensive Cancer Center (DCCC); Virtual Symposia. 2021-10-06.
2020
- (2020) PET/MRI and genetic intrapatient heterogeneity in head and neck cancers. Strahlentherapie und Onkologie (Print).
- (2020) OC-0584: Intratumoral prediction of dynamic FMISO-PET information by machine learning of multi-parametric MRI. Radiotherapy and Oncology, Volume 152, Supplement 1, 2020, Page S328, ISSN 0167-8140, https://doi.org/10.1016/S0167-8140(21)00606-X. ESTRO 2020: 39th Annual Meeting of the European Society for Radiation Therapy and Oncology (ESTRO) ; Vienna/digital. 2020-11-28 - 2020-12-01.
2019
- (2019) Multi-parametric functional imaging for personalized RT adaptations (Invited Talk). 50th Annual Meeting of the German Society for Medical Physics (DGMP) ; Stuttgart, Germany. 2019-09-18 - 2019-09-21.
- (2019) EP-2029: Principal component analysis for quantitative and robust analysis of dynamic PET/MR imaging data, Radiotherapy and Oncology, Volume 133, Supplement 1, 2019, Pages S1113-S1114, ISSN 0167-8140. ESTRO 38: 38th Annual Meeting of the European Society for Radiotherapy and Oncology (ESTRO) ; Milan. 2019-04-26 - 2019-09-30.
- (2019) Prediction of dynamic FMISO-PET voxel information by multi-parametric MRI features (Talk). 50th Annual Meeting of the German Society for Medical Physics (DGMP) ; Stuttgart, Germany. 2019-09-18 - 2019-09-21.
2018
- (2018) MR-simulation for radiotherapy treatment planning of head and neck cancer using 3T MAGNETOM Vida. MReadings: MR in RT. vol. 4.
- (2018) Image quality assessment of a dedicated hardware setup for PET/MRI in radiotherapy treatment position (Invited Talk). Medical Physics Colloquium of the German Cancer Research Center (DKFZ) ; Heidelberg, Germany. 2018-11-07.
- (2018) PCA for robust analysis of dynamic PET/MR imaging data (Talk). 2nd ESTRO Physics Workshop on Quantitative Imaging by the European Society for Radiotherapy and Oncology (ESTRO) ; Malaga. 2018-10-26 - 2018-10-27.
- (2018) Assessment of image quality of a radiotherapy-specific hardware solution for PET/MRI in head and neck cancer patients. Radiotherapy and Oncology. vol. 128 (3).
- (2018) Image quality assessment of a dedicated hardware setup for simultaneous PET/MRI in radiotherapy treatment position (Talk). 49th Annual Meeting of the German Society for Medical Physics (DGMP) - 21st Annual Meeting of the German Chapter of the International Society for Magnetic Resonance in Medicine (ISMRM) ; Nuremberg, Germany. 2018-09-19 - 2018-09-22.
- (2018) Voxel-wise correlation of functional imaging parameters in HNSCC patients receiving PET/MRI in an irradiation setup. Strahlentherapie und Onkologie (Print). vol. 194 (8).
- (2018) Potentials and challenges of diffusion-weighted magnetic resonance imaging in radiotherapy. Clinical and Translational Radiation Oncology. vol. 13.
2017
- (2017) Voxelbased analysis of FMISO-PET and diffusion-weighted MRI of two different HNSCC models in mice (Poster EP-1688). ESTRO 36: 36th Annual Meeting of the European Society for Radiotherapy and Oncology (ESTRO) ; Vienna. 2017-05-05 - 2017-05-09.
- (2017) Distortion correction of diffusion-weighted magnetic resonance imaging of the head and neck in radiotherapy position. Acta Oncologica. vol. 56 (11).
- (2017) Hardware solution for simultaneous PET/MRI in radiotherapy treatment position: diffusion-weighted imaging in head and neck cancer (Poster). BiGART 2017: 15th Acta Oncologica conference on Biology-Guided Adaptive Radiotherapy (BiGART) ; Aarhus. 2017-06-14 - 2017-06-16.
2016
- (2016) Integrated PET/MR imaging of tumor response to fractionated irradiation in xenograft models of human HNSCC - a feasibility study (Poster). Congress of the Center for Personalized Medicine (ZPM) Tuebingen ; Tuebingen, Germany. 2016-05-18 - 2016-05-20.
- (2016) Evaluation der Bildgebungseigenschaften einer Hardwareloesung fuer strahlentherapiespezifische Patientenlagerung in der PET/MR Bildgebung (Talk). 22nd Annual Meeting of the German Society for Radiation Oncology (DEGRO) ; Mannheim, Germany. 2016-06-16 - 2016-06-19.
- (2016) Evaluation of diffusion-weighted imaging properties of a RT-specific positioning solution for PET/MR imaging (Poster EP-1910). ESTRO 35: 35th Annual Meeting of the European Society for Radiotherapy and Oncology (ESTRO) ; Turin. 2016-04-29 - 2016-05-03.
2015
- (2015) Evaluation of imaging properties of a dedicated RT positioning solution for combined PET/MR imaging (Poster PD-0454, Poster Award). 3rd ESTRO Forum, Annual Meeting of the European Society for Radiotherapy and Oncology (ESTRO) ; Barcelona. 2015-04-24 - 2015-04-28.
- (2015) Prototype hardware solution to allow for RT-specific positioning of HN cancer patients during PET/MR imaging - Evaluation of imaging properties (Poster). EMIM 2015: European Molecular Imaging Meeting (EMIM), the 10th Annual Meeting of the European Society for Molecular Imaging (ESMI) ; Tuebingen, Germany. 2015-03-18 - 2015-03-20.
2014
- (2014) Evaluation of a dedicated radiotherapy positioning solution for combined PET/MR imaging (Talk). ESTRO 33: 33rd Annual Meeting of the European Society for Radiotherapy and Oncology (ESTRO) ; Vienna. 2014-04-04 - 2014-04-08.