Research activity

Our projects

Our projects

Randomised controlled multi centre study where the overall goal is to determine whether controls after drainage into the eardrum in children aged 3-10 can be performed by general practitioner without negative consequences for the patient. Primary endpoint is the child's hearing two years after surgery, and secondary endpoints are fluid in the ear, number of re-surgeries, subjective ailments, complication rate and patient satisfaction.

This project is based on the theory of a unified airway; from nose and oral cavity to the smallest lungalveole. We want to investigate occurance of nose and sinus symptoms, measure minimum cross section area, volume and maximum aif flow rate in the nose cavity of COPD patients, and compare this to a control group without COPD. Further, we want to investigate nose-sinus specific and general quality of life in COPD patients, content of inflammory cells in the nose as well as smell.

This is an RCT where 200 participants with normal sense of smell are randomised into three groups, two with different intensity of odour training (OT) and one control group without OT. The participants are followed up with three sense of smell tests over the course of a year. The goal is to examine whether odour training improves the sense of smell in patients with normal sense of smell and if intensive OT impact sense of smell more than low intensity OT. Unique for this study is that we follow up the participants for nine months after the end of treatment. Thereby, we can study if eventual changes in the sense of smell remain also in the time after OT has ended. Sixty of the participants also take part in an MR pilot study where we (1) by structural MR consider the volume of bulbus olfactorius (olfactory bulb) prior to and after the OT and (2) at resting status functional MRI studies if LT changes the activity in memory and smell centers in the brain. ​​​​​​​

In this project we want to develop and evaluate a new procedure with navigation guided injection of botulinum toxin A (BTA) for autonomous nerve blocking of ganglion sphenopalatinum (SPG) at CRSwNP. SPG is an accumulation of nerve tissue behind the sinuses. The goal with the study is to evaluate the safety of the procedure in this patient group, both related to the procedure itself and deposition of BTA against SPG with lateral access. Secondary goals are to map any symptom mitigation as well as collecting data as statistical basis for the planning of an effect study. A pilot study is planned with 10 patients.

In cooperation with the dental competence centre in Central Norway data is processed about oral mucosal disorders and the use of snus in 5000 patients in the HUNT 4 dental project.

The ENT department has a quality registry for patients undergoing surgical procedures in the nose. The registry was started in 2012 and focus on how the patients are faring after surgery. The registry is structured so that research on collected data is possible. At the moment, we have a Ph.D. student, Ann Helen Nilen, connected to the registry. She focuses on the quality of life of the patient before and after surgery to evaluate how effectively the interventions can lead to improvement. Previously, medical student Marte Fossum, has written a master's thesis about headache with the patients in the registry and surgery nurse Marit Amundsen has written her master's thesis based on the registry. We plan to use the registry for further research with astma and nasal congestion/sinus disorders and headaches.

In february 2019 Rhinlogicalq quality registry was further developed with a smell registry for patients who are referred primarily due to reduced sense of smell. The patients are smell tested at first out-patient visit, at 6 months (after odour training) and at 18 months. The goal is new knowledge of sense of smell that in the long term can improve treatment of this so far neglected patient group.

About 9500 tonsil surgeries are performed in Norway every year. Almost the same amount of surgeries are performed on children as on adults. The tonsil registry is a national registry run by St Olav's Hospital. The most important purpose of the registry is to ensure quality on diagnostics and treatment of patients who get tonsil surgery. The goal of the registry is to contribute to practice with fewer complications nationwide, and data from the registry will be used for quality improvement and health research. A systematic, national data collection is a requirement to gain new knowledge of tonsilectomy/tonsilotomy; which criteria are basis for surgical treatment, choice of surgical technique and complications in the treatment. Several research projects are planned

This is a collaberation group where Norway, Sweden, Denmark an Finland are represented. The group's goal is to compare practice in the nordic countries in order to learn from one another through research.

This is a collaberative project with the university hospital in Tromsø. Obstructive sleep apnea (OSA) is a disorder where the patient experience breathing cessation during sleep due to palate or pharynx collapse. This leads to poor sleep quality and increases risk of eg. cardiovascular disease and accidents resulting from poor oxygen saturation in the blood during sleep and fatigue/sleepiness.

CPAP is the first choice of treatment for OSA in Norway, but many experience discomfort when using and cease the treatment. An alternative to CPAP is apnea rails. Through mapping of patiant characteristics for OSA patients, we want to examine which patients benefit most from which treatment. The project's goal is to determine how a modern apnea rail differ from CPAP in regards to treatment effect, treatment compliance and impact on quality of life in patients with mild to moderate OSA. Our working hypothesis is that conventional CPAP treatment provides a somewhat better effect, while treatment with apnea rail will result in a larger portion of the patients completing treatment with good effect.

Study prevalence of chronic rhinosinusitis in Nord-Trøndelag. Study genetic tests to find out why patients develop chronic ailments with polyps and chronic sinusitis.