Course content

The course presents an overview of the principles of modern NMR spectroscopy and its application within organic chemistry. NMR puls techniques are presented. Various 1D experiments are discussed, including double resonance and those consisting of complex pulse sequences. Two-dimensional experiments and applications on static and dynamic structure determinations are reviewed. Selected examples of published applications are discussed.

Learning outcome

After having completed the course, the student should be able to:

1. Explain the basic principles of NMR at an advanced level.

2. Explain the concepts of 1D and 2D NMR experiments.

3. Show the effect of basic pulse sequences on macroscopic magnetization by applying Bloch's vector model.

4. Show and explain function of the main units of an NMR instrument.

5. Prepare a sample for an NMR experiment.

6. Process 1D and 2D NMR data by using Mnova software.

7. Analyze spectra using the same software and interpret them.

8. Elucidate structure of an unknown compound from a set of NMR spectra.

9. Design the most suitable NMR experiment setup for addressing a particular structure-related problem.

Learning methods and activities

Lectures (2 hours per week) and exercises (3 hours per week). Lectures and exercises are in English. The examination paper will only be given in English, and the answers have to be given in English as well.

Expected work load in the course is 200-225 hours.

Recommended previous knowledge

Basic principles of NMR. Course KJ2022 or related courses.

Course materials

H. Friebolin: Basic One- and Two-Dimensional NMR Spectroscopy, 5. ed., Wiley-VCH, 2011. E. Breitmaier: Structure Elucidation by NMR in Organic Chemistry, 3. ed., Wiley, 2002.

Credit reductions