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Daniel Machado

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Daniel Machado

Associate Professor
Department of Biotechnology and Food Science

daniel.machado@ntnu.no
Kjemi 3, 126, Gløshaugen
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About Research Publications Teaching Outreach

About

Daniel Machado joined NTNU in September 2020 as Associate Professor of Computational Biology. He has a Bsc/Msc in Mathematics and Computer Science (University of Minho, Portugal) and PhD in Bioengineering and Biotechnology (MIT-Portugal Program).

Competencies

  • Computational Biology
  • Metabolism
  • Modeling

Research

Our research aims to unlock the potential of microbes to address multiple societal challenges. We use computational models to understand how microbes work together in their natural habitats. These so-called microbial communities are everywhere, with some playing an important role in the health of our bodies, and others in the health of our planet. We follow an interdisciplinary approach, combining computational models and biological data, which gives us the ability to design synthetic communities to apply in multiple biotechnological applications and create more sustainable industries.

For more information check our website: 

  • Machado Lab

Cell4Chem

Designing synthetic microbial communities for conversion of lignocellulose waste products into medium-chain carboxylates

SFI - Industrial Biotechnology:

A research-based innovation centre aiming to boost the competitiveness of the Norwegian biotech industry

ELIXIR Norway

ELIXIR Norway is a national node of ELIXIR, the pan-European infrastructure for biological information, supporting life science research and its translation to medicine, environment, the bioindustries and society.

Publications

  • Chronological
  • By category
  • All publications registered in NVA

2025

  • Burgos, Idun Maria Tokvam; Øyås, Ove; Machado, Carlos Daniel Moutinho Luz. (2025) Genome-scale metabolic modeling of Ruminiclostridium cellulolyticum: a microbial cell factory for valorization of lignocellulosic biomass. BioRxiv
    Academic article
  • Landro, Benjamin; Machado, Carlos Daniel Moutinho Luz. (2025) Making Transporters Transparent for Identification and Characterization. Norges teknisk-naturvitenskapelige universitet Norges teknisk-naturvitenskapelige universitet
    Masters thesis
  • Hudgins, Eliah; Machado, Carlos Daniel Moutinho Luz. (2025) Predicting microbial traits from genome annotations. Norges teknisk-naturvitenskapelige universitet Norges teknisk-naturvitenskapelige universitet
    Masters thesis

2024

  • Machado, Carlos Daniel Moutinho Luz. (2024) A benchmark of optimization solvers for genome-scale metabolic modeling of organisms and communities. mSystems
    Academic article
  • Stallvik, Andrea; Machado, Carlos Daniel Moutinho Luz. (2024) Designing microbial consortia using metabolic modelling. Norges teknisk-naturvitenskapelige universitet Norges teknisk-naturvitenskapelige universitet
    Masters thesis

2023

  • Røed, Elin Sandertun; Machado, Carlos Daniel Moutinho Luz; Márquez-Zavala, Elisa. (2023) Predicting Allosteric Regulation at Genome Scale. Norges teknisk-naturvitenskapelige universitet Norges teknisk-naturvitenskapelige universitet
    Masters thesis
  • Eggelen, Marieke Cecilia van; Machado, Daniel; Machado, Carlos Daniel Moutinho Luz; Burgos, Idun Maria Tokvam. (2023) Predicting metabolic fluxes from gene expression data using machine learning. Norges teknisk-naturvitenskapelige universitet Norges teknisk-naturvitenskapelige universitet
    Masters thesis
  • Melkonian, Chrats; Zorrilla, Francisco; Kjærbølling, Inge; Blasche, Sonja; Machado, Carlos Daniel Moutinho Luz; Junge, Mette. (2023) Microbial interactions shape cheese flavour formation. Nature Communications
    Academic article

2022

  • Cerca, José; Petersen, Bent; Lazaro-Guevara, José Miguel; Rivera-Colón, Angel G.; Birkeland, Siri; Vizueta, Joel. (2022) The genomic basis of the plant island syndrome in Darwin’s giant daisies. Nature Communications
    Academic article
  • Lien, Martin Eide; Machado, Carlos Daniel Moutinho Luz. (2022) Metabolic network layout using biochemical coordinates. Norges teknisk-naturvitenskapelige universitet Norges teknisk-naturvitenskapelige universitet
    Masters thesis
  • Merkesvik, Jenny; Machado, Carlos Daniel Moutinho Luz. (2022) Towards genotype—phenotype association: leveraging multiple-source microbial data and genome annotations to infer trait attributes for the uncultured microbiome. Norges teknisk-naturvitenskapelige universitet Norges teknisk-naturvitenskapelige universitet
    Masters thesis
  • Machado, Daniel; Patil, Kiran R.. (2022) Reply to: Erroneous predictions of auxotrophies by CarveMe. Nature Ecology and Evolution
    Reader opinion piece
  • Berg, Naomi Iris van den; Machado, Daniel; Santos, Sophia; Rocha, Isabel; Chacón, Jeremy; Harcombe, William. (2022) Ecological modelling approaches for predicting emergent properties in microbial communities. Nature Ecology and Evolution
    Academic literature review

2021

  • Machado, Daniel; Maistrenko, Oleksandr M.; Andrejev, Sergej; Kim, Yongkyu; Bork, Peer; Patil, Kaustubh R.. (2021) Polarization of microbial communities between competitive and cooperative metabolism. Nature Ecology and Evolution
    Academic article
  • Alloul, Abbas; Spanoghe, Janne; Machado, Daniel; Vlaeminck, Siegfried E.. (2021) Unlocking the genomic potential of aerobes and phototrophs for the production of nutritious and palatable microbial food without arable land or fossil fuels. Microbial Biotechnology
    Academic article
  • Shechter, Ksenija Radic; Kafkia, Eleni; Zirngibl, Katharina; Gawrzak, Sylwia; Alladin, Ashna; Machado, Daniel. (2021) Metabolic memory underlying minimal residual disease in breast cancer. Molecular Systems Biology
    Academic article
  • Blasche, Sonja; Kim, Yongkyu; Mars, Ruben A.T.; Machado, Daniel; Maansson, Maria; Kafkia, Eleni. (2021) Metabolic cooperation and spatiotemporal niche partitioning in a kefir microbial community. Nature Microbiology
    Academic article

2020

  • Lieven, Christian; Beber, Moritz E.; Olivier, Brett G.; Bergmann, Frank T.; Ataman, Meric; Babaei, Parizad. (2020) MEMOTE for standardized genome-scale metabolic model testing. Nature Biotechnology
    Academic article

Journal publications

  • Burgos, Idun Maria Tokvam; Øyås, Ove; Machado, Carlos Daniel Moutinho Luz. (2025) Genome-scale metabolic modeling of Ruminiclostridium cellulolyticum: a microbial cell factory for valorization of lignocellulosic biomass. BioRxiv
    Academic article
  • Machado, Carlos Daniel Moutinho Luz. (2024) A benchmark of optimization solvers for genome-scale metabolic modeling of organisms and communities. mSystems
    Academic article
  • Melkonian, Chrats; Zorrilla, Francisco; Kjærbølling, Inge; Blasche, Sonja; Machado, Carlos Daniel Moutinho Luz; Junge, Mette. (2023) Microbial interactions shape cheese flavour formation. Nature Communications
    Academic article
  • Cerca, José; Petersen, Bent; Lazaro-Guevara, José Miguel; Rivera-Colón, Angel G.; Birkeland, Siri; Vizueta, Joel. (2022) The genomic basis of the plant island syndrome in Darwin’s giant daisies. Nature Communications
    Academic article
  • Machado, Daniel; Patil, Kiran R.. (2022) Reply to: Erroneous predictions of auxotrophies by CarveMe. Nature Ecology and Evolution
    Reader opinion piece
  • Berg, Naomi Iris van den; Machado, Daniel; Santos, Sophia; Rocha, Isabel; Chacón, Jeremy; Harcombe, William. (2022) Ecological modelling approaches for predicting emergent properties in microbial communities. Nature Ecology and Evolution
    Academic literature review
  • Machado, Daniel; Maistrenko, Oleksandr M.; Andrejev, Sergej; Kim, Yongkyu; Bork, Peer; Patil, Kaustubh R.. (2021) Polarization of microbial communities between competitive and cooperative metabolism. Nature Ecology and Evolution
    Academic article
  • Alloul, Abbas; Spanoghe, Janne; Machado, Daniel; Vlaeminck, Siegfried E.. (2021) Unlocking the genomic potential of aerobes and phototrophs for the production of nutritious and palatable microbial food without arable land or fossil fuels. Microbial Biotechnology
    Academic article
  • Shechter, Ksenija Radic; Kafkia, Eleni; Zirngibl, Katharina; Gawrzak, Sylwia; Alladin, Ashna; Machado, Daniel. (2021) Metabolic memory underlying minimal residual disease in breast cancer. Molecular Systems Biology
    Academic article
  • Blasche, Sonja; Kim, Yongkyu; Mars, Ruben A.T.; Machado, Daniel; Maansson, Maria; Kafkia, Eleni. (2021) Metabolic cooperation and spatiotemporal niche partitioning in a kefir microbial community. Nature Microbiology
    Academic article
  • Lieven, Christian; Beber, Moritz E.; Olivier, Brett G.; Bergmann, Frank T.; Ataman, Meric; Babaei, Parizad. (2020) MEMOTE for standardized genome-scale metabolic model testing. Nature Biotechnology
    Academic article

Report

  • Landro, Benjamin; Machado, Carlos Daniel Moutinho Luz. (2025) Making Transporters Transparent for Identification and Characterization. Norges teknisk-naturvitenskapelige universitet Norges teknisk-naturvitenskapelige universitet
    Masters thesis
  • Hudgins, Eliah; Machado, Carlos Daniel Moutinho Luz. (2025) Predicting microbial traits from genome annotations. Norges teknisk-naturvitenskapelige universitet Norges teknisk-naturvitenskapelige universitet
    Masters thesis
  • Stallvik, Andrea; Machado, Carlos Daniel Moutinho Luz. (2024) Designing microbial consortia using metabolic modelling. Norges teknisk-naturvitenskapelige universitet Norges teknisk-naturvitenskapelige universitet
    Masters thesis
  • Røed, Elin Sandertun; Machado, Carlos Daniel Moutinho Luz; Márquez-Zavala, Elisa. (2023) Predicting Allosteric Regulation at Genome Scale. Norges teknisk-naturvitenskapelige universitet Norges teknisk-naturvitenskapelige universitet
    Masters thesis
  • Eggelen, Marieke Cecilia van; Machado, Daniel; Machado, Carlos Daniel Moutinho Luz; Burgos, Idun Maria Tokvam. (2023) Predicting metabolic fluxes from gene expression data using machine learning. Norges teknisk-naturvitenskapelige universitet Norges teknisk-naturvitenskapelige universitet
    Masters thesis
  • Lien, Martin Eide; Machado, Carlos Daniel Moutinho Luz. (2022) Metabolic network layout using biochemical coordinates. Norges teknisk-naturvitenskapelige universitet Norges teknisk-naturvitenskapelige universitet
    Masters thesis
  • Merkesvik, Jenny; Machado, Carlos Daniel Moutinho Luz. (2022) Towards genotype—phenotype association: leveraging multiple-source microbial data and genome annotations to infer trait attributes for the uncultured microbiome. Norges teknisk-naturvitenskapelige universitet Norges teknisk-naturvitenskapelige universitet
    Masters thesis

Teaching

Courses

  • BT8120 - Prokaryote Molecular Biology and Synthetic Biology
  • BT2100 - Computational Biotechnology
  • TBT4508 - Bioinformatics and Biopolymeric Materials, Specialization Course
  • TBT4507 - Bioinformatics and Experimental design and data analysis, Specialization Course

Outreach

Finding Genius Podcast

Harnessing the Ecology of Microbial Communities with Daniel Machado

2025

  • Poster
    Hudgins, Eliah; Machado, Carlos Daniel Moutinho Luz. (2025) Predicting Microbial traits from genome annotations. 60th NBS contact meeting , Røros 2025-01-23 - 2025-01-26

2024

  • Lecture
    Burgos, Idun Maria Tokvam; Øyås, Ove; Machado, Carlos Daniel Moutinho Luz. (2024) Elucidating the roles of bacteria in cellulose- and xylan-enriched communities with genome-scale metabolic models. Norwegian Bioinformatics Days 2024 , Bergen, Norway 2024-05-28 - 2024-05-30
  • Poster
    Stallvik, Andrea; Burgos, Idun Maria Tokvam; Machado, Carlos Daniel Moutinho Luz. (2024) Designing microbial consortia using metabolic modelling – possibilities and limitations. Norwegian Bioinformatics Days 2024 , Bergen, Norway 2024-05-28 - 2024-05-30
  • Poster
    Zavala, Elisa Marquez; Bartolomeo, Francesca Di; Machado, Carlos Daniel Moutinho Luz. (2024) Automated Data Retrieval and Analysis for Enhanced Product Production. Norwegian Bioinformatics Days 2024 , Bergen, Norway 2024-05-28 - 2024-05-30
  • Poster
    Teixeira, Miguel Alves Magalhaes; Machado, Carlos Daniel Moutinho Luz. (2024) Trust the universe - enlightening microbial metabolism with CarveMe’s new universal model. 19th International Symposium on Microbial Ecology , Cape Town, South Africa 2024-08-18 - 2024-08-23
  • Lecture
    Zavala, Elisa Marquez; Bartolomeo, Francesca Di; Machado, Carlos Daniel Moutinho Luz. (2024) Can you outsmart nature? Level Up your Cell Factories with ELISER. Joint conference of the 15th Globe Industrial Microbiology Congress (GIM) & Metabolic Engineering Summit (MES 2024) , Shangai 2024-09-20 - 2024-09-25

2023

  • Poster
    Stallvik, Andrea; Machado, Carlos Daniel Moutinho Luz. (2023) Synthetic Microbial Communities for the Production of High-Value Compounds. 58th Norwegian Biochemical Society Meeting , Ås, Norway 2023-01-19 - 2023-01-22
  • Poster
    Teixeira, Miguel Alves Magalhaes; Machado, Carlos Daniel Moutinho Luz. (2023) CarveMe roadmap: expanding genome-scale metabolic model reconstructions. ISMB/ECCB 2023 , Lyon, France 2023-07-23 - 2023-07-27

2022

  • Poster
    Teixeira, Miguel; Machado, Daniel. (2022) CarveMe roadmap: expanding genome-scale metabolic models’ reconstruction. ISME 18 , Lausanne, Switzerland 2022-08-14 - 2022-08-19
  • Poster
    Burgos, Idun Maria Tokvam; Machado, Daniel. (2022) Modeling The Conversion Of Lignocellulose Into Medium-chain Carboxylates. ISME 18 , Lausanne, Switzerland 2022-08-14 - 2022-08-19

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