Daniel Machado
About
Daniel Machado joined NTNU in September 2020 as Associate Professor of Computational Biology. He has a Bsc/Msc in Mathematics and Computer Science (University of Minho, Portugal) and PhD in Bioengineering and Biotechnology (MIT-Portugal Program).
Competencies
Research
Our research aims to unlock the potential of microbes to address multiple societal challenges. We use computational models to understand how microbes work together in their natural habitats. These so-called microbial communities are everywhere, with some playing an important role in the health of our bodies, and others in the health of our planet. We follow an interdisciplinary approach, combining computational models and biological data, which gives us the ability to design synthetic communities to apply in multiple biotechnological applications and create more sustainable industries.
For more information check our website:
Cell4Chem
SFI - Industrial Biotechnology:
ELIXIR Norway
Publications
2025
-
Burgos, Idun Maria Tokvam;
Øyås, Ove;
Machado, Carlos Daniel Moutinho Luz.
(2025)
Genome-scale metabolic modeling of Ruminiclostridium cellulolyticum: a microbial cell factory for valorization of lignocellulosic biomass.
BioRxiv
Academic article
-
Landro, Benjamin;
Machado, Carlos Daniel Moutinho Luz.
(2025)
Making Transporters Transparent for Identification and Characterization.
Norges teknisk-naturvitenskapelige universitet
Norges teknisk-naturvitenskapelige universitet
Masters thesis
-
Hudgins, Eliah;
Machado, Carlos Daniel Moutinho Luz.
(2025)
Predicting microbial traits from genome annotations.
Norges teknisk-naturvitenskapelige universitet
Norges teknisk-naturvitenskapelige universitet
Masters thesis
2024
-
Machado, Carlos Daniel Moutinho Luz.
(2024)
A benchmark of optimization solvers for genome-scale metabolic modeling of organisms and communities.
mSystems
Academic article
-
Stallvik, Andrea;
Machado, Carlos Daniel Moutinho Luz.
(2024)
Designing microbial consortia using metabolic modelling.
Norges teknisk-naturvitenskapelige universitet
Norges teknisk-naturvitenskapelige universitet
Masters thesis
2023
-
Røed, Elin Sandertun;
Machado, Carlos Daniel Moutinho Luz;
Márquez-Zavala, Elisa.
(2023)
Predicting Allosteric Regulation at Genome Scale.
Norges teknisk-naturvitenskapelige universitet
Norges teknisk-naturvitenskapelige universitet
Masters thesis
-
Eggelen, Marieke Cecilia van;
Machado, Daniel;
Machado, Carlos Daniel Moutinho Luz;
Burgos, Idun Maria Tokvam.
(2023)
Predicting metabolic fluxes from gene expression data using machine learning.
Norges teknisk-naturvitenskapelige universitet
Norges teknisk-naturvitenskapelige universitet
Masters thesis
-
Melkonian, Chrats;
Zorrilla, Francisco;
Kjærbølling, Inge;
Blasche, Sonja;
Machado, Carlos Daniel Moutinho Luz;
Junge, Mette.
(2023)
Microbial interactions shape cheese flavour formation.
Nature Communications
Academic article
2022
-
Cerca, José;
Petersen, Bent;
Lazaro-Guevara, José Miguel;
Rivera-Colón, Angel G.;
Birkeland, Siri;
Vizueta, Joel.
(2022)
The genomic basis of the plant island syndrome in Darwin’s giant daisies.
Nature Communications
Academic article
-
Lien, Martin Eide;
Machado, Carlos Daniel Moutinho Luz.
(2022)
Metabolic network layout using biochemical coordinates.
Norges teknisk-naturvitenskapelige universitet
Norges teknisk-naturvitenskapelige universitet
Masters thesis
-
Merkesvik, Jenny;
Machado, Carlos Daniel Moutinho Luz.
(2022)
Towards genotype—phenotype association: leveraging multiple-source microbial data and genome annotations to infer trait attributes for the uncultured microbiome.
Norges teknisk-naturvitenskapelige universitet
Norges teknisk-naturvitenskapelige universitet
Masters thesis
-
Machado, Daniel;
Patil, Kiran R..
(2022)
Reply to: Erroneous predictions of auxotrophies by CarveMe.
Nature Ecology and Evolution
Reader opinion piece
-
Berg, Naomi Iris van den;
Machado, Daniel;
Santos, Sophia;
Rocha, Isabel;
Chacón, Jeremy;
Harcombe, William.
(2022)
Ecological modelling approaches for predicting emergent properties in microbial communities.
Nature Ecology and Evolution
Academic literature review
2021
-
Machado, Daniel;
Maistrenko, Oleksandr M.;
Andrejev, Sergej;
Kim, Yongkyu;
Bork, Peer;
Patil, Kaustubh R..
(2021)
Polarization of microbial communities between competitive and cooperative metabolism.
Nature Ecology and Evolution
Academic article
-
Alloul, Abbas;
Spanoghe, Janne;
Machado, Daniel;
Vlaeminck, Siegfried E..
(2021)
Unlocking the genomic potential of aerobes and phototrophs for the production of nutritious and palatable microbial food without arable land or fossil fuels.
Microbial Biotechnology
Academic article
-
Shechter, Ksenija Radic;
Kafkia, Eleni;
Zirngibl, Katharina;
Gawrzak, Sylwia;
Alladin, Ashna;
Machado, Daniel.
(2021)
Metabolic memory underlying minimal residual disease in breast cancer.
Molecular Systems Biology
Academic article
-
Blasche, Sonja;
Kim, Yongkyu;
Mars, Ruben A.T.;
Machado, Daniel;
Maansson, Maria;
Kafkia, Eleni.
(2021)
Metabolic cooperation and spatiotemporal niche partitioning in a kefir microbial community.
Nature Microbiology
Academic article
2020
-
Lieven, Christian;
Beber, Moritz E.;
Olivier, Brett G.;
Bergmann, Frank T.;
Ataman, Meric;
Babaei, Parizad.
(2020)
MEMOTE for standardized genome-scale metabolic model testing.
Nature Biotechnology
Academic article
Journal publications
-
Burgos, Idun Maria Tokvam;
Øyås, Ove;
Machado, Carlos Daniel Moutinho Luz.
(2025)
Genome-scale metabolic modeling of Ruminiclostridium cellulolyticum: a microbial cell factory for valorization of lignocellulosic biomass.
BioRxiv
Academic article
-
Machado, Carlos Daniel Moutinho Luz.
(2024)
A benchmark of optimization solvers for genome-scale metabolic modeling of organisms and communities.
mSystems
Academic article
-
Melkonian, Chrats;
Zorrilla, Francisco;
Kjærbølling, Inge;
Blasche, Sonja;
Machado, Carlos Daniel Moutinho Luz;
Junge, Mette.
(2023)
Microbial interactions shape cheese flavour formation.
Nature Communications
Academic article
-
Cerca, José;
Petersen, Bent;
Lazaro-Guevara, José Miguel;
Rivera-Colón, Angel G.;
Birkeland, Siri;
Vizueta, Joel.
(2022)
The genomic basis of the plant island syndrome in Darwin’s giant daisies.
Nature Communications
Academic article
-
Machado, Daniel;
Patil, Kiran R..
(2022)
Reply to: Erroneous predictions of auxotrophies by CarveMe.
Nature Ecology and Evolution
Reader opinion piece
-
Berg, Naomi Iris van den;
Machado, Daniel;
Santos, Sophia;
Rocha, Isabel;
Chacón, Jeremy;
Harcombe, William.
(2022)
Ecological modelling approaches for predicting emergent properties in microbial communities.
Nature Ecology and Evolution
Academic literature review
-
Machado, Daniel;
Maistrenko, Oleksandr M.;
Andrejev, Sergej;
Kim, Yongkyu;
Bork, Peer;
Patil, Kaustubh R..
(2021)
Polarization of microbial communities between competitive and cooperative metabolism.
Nature Ecology and Evolution
Academic article
-
Alloul, Abbas;
Spanoghe, Janne;
Machado, Daniel;
Vlaeminck, Siegfried E..
(2021)
Unlocking the genomic potential of aerobes and phototrophs for the production of nutritious and palatable microbial food without arable land or fossil fuels.
Microbial Biotechnology
Academic article
-
Shechter, Ksenija Radic;
Kafkia, Eleni;
Zirngibl, Katharina;
Gawrzak, Sylwia;
Alladin, Ashna;
Machado, Daniel.
(2021)
Metabolic memory underlying minimal residual disease in breast cancer.
Molecular Systems Biology
Academic article
-
Blasche, Sonja;
Kim, Yongkyu;
Mars, Ruben A.T.;
Machado, Daniel;
Maansson, Maria;
Kafkia, Eleni.
(2021)
Metabolic cooperation and spatiotemporal niche partitioning in a kefir microbial community.
Nature Microbiology
Academic article
-
Lieven, Christian;
Beber, Moritz E.;
Olivier, Brett G.;
Bergmann, Frank T.;
Ataman, Meric;
Babaei, Parizad.
(2020)
MEMOTE for standardized genome-scale metabolic model testing.
Nature Biotechnology
Academic article
Report
-
Landro, Benjamin;
Machado, Carlos Daniel Moutinho Luz.
(2025)
Making Transporters Transparent for Identification and Characterization.
Norges teknisk-naturvitenskapelige universitet
Norges teknisk-naturvitenskapelige universitet
Masters thesis
-
Hudgins, Eliah;
Machado, Carlos Daniel Moutinho Luz.
(2025)
Predicting microbial traits from genome annotations.
Norges teknisk-naturvitenskapelige universitet
Norges teknisk-naturvitenskapelige universitet
Masters thesis
-
Stallvik, Andrea;
Machado, Carlos Daniel Moutinho Luz.
(2024)
Designing microbial consortia using metabolic modelling.
Norges teknisk-naturvitenskapelige universitet
Norges teknisk-naturvitenskapelige universitet
Masters thesis
-
Røed, Elin Sandertun;
Machado, Carlos Daniel Moutinho Luz;
Márquez-Zavala, Elisa.
(2023)
Predicting Allosteric Regulation at Genome Scale.
Norges teknisk-naturvitenskapelige universitet
Norges teknisk-naturvitenskapelige universitet
Masters thesis
-
Eggelen, Marieke Cecilia van;
Machado, Daniel;
Machado, Carlos Daniel Moutinho Luz;
Burgos, Idun Maria Tokvam.
(2023)
Predicting metabolic fluxes from gene expression data using machine learning.
Norges teknisk-naturvitenskapelige universitet
Norges teknisk-naturvitenskapelige universitet
Masters thesis
-
Lien, Martin Eide;
Machado, Carlos Daniel Moutinho Luz.
(2022)
Metabolic network layout using biochemical coordinates.
Norges teknisk-naturvitenskapelige universitet
Norges teknisk-naturvitenskapelige universitet
Masters thesis
-
Merkesvik, Jenny;
Machado, Carlos Daniel Moutinho Luz.
(2022)
Towards genotype—phenotype association: leveraging multiple-source microbial data and genome annotations to infer trait attributes for the uncultured microbiome.
Norges teknisk-naturvitenskapelige universitet
Norges teknisk-naturvitenskapelige universitet
Masters thesis
Teaching
Courses
Outreach
2025
-
PosterHudgins, Eliah; Machado, Carlos Daniel Moutinho Luz. (2025) Predicting Microbial traits from genome annotations. 60th NBS contact meeting , Røros 2025-01-23 - 2025-01-26
2024
-
LectureBurgos, Idun Maria Tokvam; Øyås, Ove; Machado, Carlos Daniel Moutinho Luz. (2024) Elucidating the roles of bacteria in cellulose- and xylan-enriched communities with genome-scale metabolic models. Norwegian Bioinformatics Days 2024 , Bergen, Norway 2024-05-28 - 2024-05-30
-
PosterStallvik, Andrea; Burgos, Idun Maria Tokvam; Machado, Carlos Daniel Moutinho Luz. (2024) Designing microbial consortia using metabolic modelling – possibilities and limitations. Norwegian Bioinformatics Days 2024 , Bergen, Norway 2024-05-28 - 2024-05-30
-
PosterZavala, Elisa Marquez; Bartolomeo, Francesca Di; Machado, Carlos Daniel Moutinho Luz. (2024) Automated Data Retrieval and Analysis for Enhanced Product Production. Norwegian Bioinformatics Days 2024 , Bergen, Norway 2024-05-28 - 2024-05-30
-
PosterTeixeira, Miguel Alves Magalhaes; Machado, Carlos Daniel Moutinho Luz. (2024) Trust the universe - enlightening microbial metabolism with CarveMe’s new universal model. 19th International Symposium on Microbial Ecology , Cape Town, South Africa 2024-08-18 - 2024-08-23
-
LectureZavala, Elisa Marquez; Bartolomeo, Francesca Di; Machado, Carlos Daniel Moutinho Luz. (2024) Can you outsmart nature? Level Up your Cell Factories with ELISER. Joint conference of the 15th Globe Industrial Microbiology Congress (GIM) & Metabolic Engineering Summit (MES 2024) , Shangai 2024-09-20 - 2024-09-25
2023
-
PosterStallvik, Andrea; Machado, Carlos Daniel Moutinho Luz. (2023) Synthetic Microbial Communities for the Production of High-Value Compounds. 58th Norwegian Biochemical Society Meeting , Ås, Norway 2023-01-19 - 2023-01-22
-
PosterTeixeira, Miguel Alves Magalhaes; Machado, Carlos Daniel Moutinho Luz. (2023) CarveMe roadmap: expanding genome-scale metabolic model reconstructions. ISMB/ECCB 2023 , Lyon, France 2023-07-23 - 2023-07-27
2022
-
PosterTeixeira, Miguel; Machado, Daniel. (2022) CarveMe roadmap: expanding genome-scale metabolic models’ reconstruction. ISME 18 , Lausanne, Switzerland 2022-08-14 - 2022-08-19
-
PosterBurgos, Idun Maria Tokvam; Machado, Daniel. (2022) Modeling The Conversion Of Lignocellulose Into Medium-chain Carboxylates. ISME 18 , Lausanne, Switzerland 2022-08-14 - 2022-08-19