Oddgeir Lingaas Holmen

About

Oddgeir Lingaas Holmen holds the roles as Head of HUNT Cloud and Chief Information Security Officer of HUNT Cloud at NTNU.

Oddgeir Lingaas Holmen received his M.D. from the Norwegian University of Science and Technology (NTNU) in 2008 and joined the Department of Public Health and Nursing in 2010.

Holmen holds a PhD in genetic epidemiology under the mentorship of professor Kristian Hveem. The work involved close collaborations with Cristen Willer, Goncalo Abecasis and Michael Boehnke from the University of Michigan, and Michael Weedon and Tim Frayling at the University of Exeter.

Cristen Willer and Oddgeir Lingaas Holmen initiated the HUNT-MI collaboration in 2010 between the HUNT study and the University of Michigan. Holmen has been a part of the HUNT-MI steering committee together with Kristian Hveem, Cristen Willer, Goncalo Abecasis and Michael Boehnke since 2011.

The HUNT-MI collaboration has among others coordinated genotyping of more than 70,000 HUNT-participants in the ALL-IN substudy.

Hveem and Holmen initiated HUNT Cloud in 2013 as a computational infrastructure for collection, accessibility and analysis of sensitive information tailored to large-scale information. Holmen has since been managing the development team.

Holmen worked alongside Kristian Hveem to establish the K.G. Jebsen center for genetic epidemiology in 2016. The center now coordinate more than 50 ALL-IN studies investigating the associations between genetic variation and a large number of diseases.

Oddgeir Lingaas Holmen has since 2017 been fully devoted to the team that develop HUNT Cloud. This included a complete rebuild of the data center infrastructure, and the certification of HUNT Cloud's management systems for quality (ISO 9001) and information security (ISO 27001) in 2017.

PGP: 5925 AB67 F199 0AE5 911F B75B F945 3DEC 7736 96D4

Selected papers

Nielsen JB, Fritsche LG, Zhou W, Teslovich T, Holmen OL, et al. (2018) Genome-wide study of atrial fibrillation identifies seven risk loci and highlights biological pathways and regulatory elements involved in cardiac development. American Journal of Human Genetics.

Holmen OL, Zhang H, Fan Y, Hovelson DH, Schmidt EM, et al. (2014) Systematic evaluation of coding variation identifies a candidate causal variant in TM6SF2 influencing total cholesterol and myocardial infarction risk. Nature Genetics.

Liu DJ, Peloso GM, Zhan X, Holmen OL, Zawistowski M, et al. (2014) Meta-analysis of gene-level tests for rare variant association. Nature Genetics.

Chan Y, Holmen OL, Dauber A, Vatten L, Havulinna AS, et al. (2011) Common Variants Show Predicted Polygenic Effects on Height in the Tails of the Distribution, Except in Extremely Short Individuals. PLoS Genetics.

Holmen OL, Backe B (2009) An underdiagnosed cause of nipple pain presented on a camera phone. BMJ 339.

Pubmed
Google Scholar

Publications

2025

Dand, Nick; Stuart, Philip E.; Bowes, John; Ellinghaus, David; Nititham, Joanne; Saklatvala, Jake R.. (2025) GWAS meta-analysis of psoriasis identifies new susceptibility alleles impacting disease mechanisms and therapeutic targets. Nature Communications
Academic article

2024

Helgeland, Øyvind; Vaudel, Marc; Sole-Navais, Pol; Flatley, Christopher; Juodakis, Julius; Bacelis, Jonas. (2024) Correction to: Characterization of the genetic architecture of infant and early childhood body mass index (Nature Metabolism, (2022), 4, 3, (344-358), 10.1038/s42255-022-00549-1). Nature Metabolism
Errata

2023

Lagou, Vasiliki; Jiang, Longda; Ulrich, Anna; Zudina, Liudmila; González, Karla Sofia Gutiérrez; Balkhiyarova, Zhanna. (2023) GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification. Nature Genetics
Academic article

2022

Brumpton, Ben Michael; Graham, Sarah; Surakka, Ida; Skogholt, Anne Heidi; Løset, Mari; Fritsche, Lars G.. (2022) The HUNT study: A population-based cohort for genetic research. Cell Genomics
Academic article
Bahrami, Shahram; Hindley, Guy Frederick Lanyon; Winsvold, Bendik K S; O'Connell, Kevin Sean; Frei, Oleksandr; Shadrin, Alexey. (2022) Dissecting the shared genetic basis of migraine and mental disorders using novel statistical tools. Brain
Academic article
Helgeland, Øyvind; Vaudel, Marc; Sole-Navais, Pol; Flatley, Christopher; Juodakis, Julius; Bacelis, Jonas. (2022) Characterization of the genetic architecture of infant and early childhood body mass index. Nature Metabolism
Academic article

2021

Freidin, Maxim B.; Tsepilov, Yakov A.; Stanaway, Ian B.; Meng, Weihua; Hayward, Caroline; Smith, Blair H.. (2021) Sex- and age-specific genetic analysis of chronic back pain. Pain
Academic article
Bianchini, Federico; Birkeland, Even; Bösl, Korbinian; Gade, Alexandra; Holmen, Oddgeir Lingaas; Hu, Xian. (2021) BioMedData Deliverable D2.1 - Report on data management plan needs/gaps. Zenodo Zenodo
Report

2020

Nielsen, Jonas Bille; Rom, Oren; Surakka, Ida; Graham, Sarah E.; Zhou, Wei; Roychowdhury, Tanmoy. (2020) Loss-of-function genomic variants highlight potential therapeutic targets for cardiovascular disease. Nature Communications
Academic article

2019

Rounge, Trine Ballestad; Lauritzen, Marianne; Erlandsen, Sten Even; Langseth, Hilde; Holmen, Oddgeir Lingaas; Gislefoss, Randi Elin. (2019) Ultralow amounts of DNA from long-term archived serum samples produce quality genotypes. European Journal of Human Genetics
Academic article
Lyngbakken, Magnus; Røsjø, Helge; Holmen, Oddgeir Lingaas; Dalen, Håvard; Hveem, Kristian; Omland, Torbjørn. (2019) Temporal changes in cardiac troponin i are associated with risk of cardiovascular events in the general population: The Nord-Trøndelag health study. Clinical Chemistry
Academic article
Justice, Anne E.; Karaderi, Tugce; Highland, Heather M.; Young, Kristin L.; Graff, Mariaelisa; Lu, Yingchang. (2019) Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution. Nature Genetics
Academic article
Turcot, Valérie; Lu, Yingchang; Highland, Heather M.; Schurmann, Claudia; Justice, Anne E.; Fine, Rebecca S.. (2019) Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity (Nature Genetics, (2018), 50, 1, (26-41), 10.1038/s41588-017-0011-x). Nature Genetics
Errata
Helgeland, Øyvind; Vaudel, Marc; Juliusson, Petur Benedikt; Holmen, Oddgeir Lingaas; Juodakis, Julius; Bacelis, Jonas. (2019) Genome-wide association study reveals dynamic role of genetic variation in infant and early childhood growth. Nature Communications
Academic article

2018

Løset, Mari; Modalsli, Ellen Heilmann; Snekvik, Ingrid; Solvin, Åshild Øksnevad; Holmen, Oddgeir Lingaas; Gabrielsen, Maiken Elvestad. (2018) 743 HUNTing for genes that affect inflammatory skin disease in 4,071 cases and 40,430 controls. Journal of Investigative Dermatology
Abstract
Turcot, Valérie; Helgeland, Øyvind; Holmen, Oddgeir Lingaas; Johansson, Stefan; Njølstad, Pål Rasmus; Loos, Ruth J.F.. (2018) Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. Nature Genetics
Errata
Sigurdardottir, Fjola Dogg; Lyngbakken, Magnus Nakrem; Holmen, Oddgeir Lingaas; Dalen, Håvard; Hveem, Kristian; Røsjø, Helge. (2018) Relative prognostic value of cardiac troponin I and C-reactive protein in the general population (from the Nord-Trøndelag Health [HUNT] Study). American Journal of Cardiology
Academic article
Nielsen, Jonas B.; Fritsche, Lars; Zhou, Wei; Teslovich, Tanya M.; Holmen, Oddgeir Lingaas; Gustafsson, Stefan. (2018) Genome-wide Study of Atrial Fibrillation Identifies Seven Risk Loci and Highlights Biological Pathways and Regulatory Elements Involved in Cardiac Development. American Journal of Human Genetics
Academic article
Nielsen, Jonas B.; Thorolfsdottir, Rosa B.; Fritsche, Lars; Zhou, Wei; Skov, Morten W.; Graham, Sarah E.. (2018) Biobank-driven genomic discovery yields new insight into atrial fibrillation biology. Nature Genetics
Academic article
Thorolfsdottir, Rosa B; Sveinbjornsson, Gardar; Sulem, Patrick; Nielsen, Jonas B.; Jonsson, Stefan; Halldorsson, Gisli H. (2018) Coding variants in RPL3L and MYZAP increase risk of atrial fibrillation. Communications Biology
Academic article
Turcot, Valérie; Lu, Yingchang; Highland, Heather M.; Schurmann, Claudia; Justice, Anne E.; Fine, Rebecca S.. (2018) Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. Nature Genetics
Academic article
Gusarova, Viktoria; O'Dushlaine, Colm; Teslovich, Tanya M.; Benotti, Peter N.; Mirshahi, Tooraj; Gottesman, Omri. (2018) Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes. Nature Communications
Academic article

2017

Webb, Thomas R.; Erdmann, Jeanette; Stirrups, Kathleen E.; Stitziel, Nathan O.; Masca, Nicholas G.D.; Jansen, Henning. (2017) Systematic evaluation of pleiotropy identifies 6 further loci associated with coronary artery disease. Journal of the American College of Cardiology
Academic article
Justice, Anne E.; Winkler, Thomas W.; Feitosa, Mary F.; Graff, Misa; Fisher, Virginia A.; Young, Kristin. (2017) Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits. Nature Communications
Academic article
Ferreira, Manuel A.; Vonk, Judith M; Baurecht, Hansjörg; Marenholz, Ingo; Tian, Chao; Hoffman, Joshua D. (2017) Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology. Nature Genetics
Academic article
Liu, Dajiang J.; Peloso, Gina M.; Yu, Haojie; Butterworth, Adam S.; Wang, Xiao; Mahajan, Anubha. (2017) Exome-wide association study of plasma lipids in &gt;300,000 individuals. Nature Genetics
Academic article
Graff, Mariaelisa; Scott, Robert A.; Justice, Anne E.; Young, Kristin L.; Feitosa, Mary F.; Barata, Llilda. (2017) Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults. PLoS Genetics
Academic article
Zhou, Wei; Fritsche, Lars; Das, Sayantan; Zhang, He; Nielsen, Jonas B.; Holmen, Oddgeir Lingaas. (2017) Improving power of association tests using multiple sets of imputed genotypes from distributed reference panels. Genetic Epidemiology
Academic article

2016

Stitziel, Nathan O.; Stirrups, Kathleen E.; Masca, Nicholas G.D.; Erdmann, Jeanette; Ferrario, Paola G.; König, Inke R.. (2016) Coding variation in ANGPTL4, LPL, and SVEP1 and the risk of coronary disease. New England Journal of Medicine
Academic article
Surendran, Praveen; Drenos, Fotios; Young, Robin; Warren, Helen; Cook, James P.; Manning, Alisa K.. (2016) Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension. Nature Genetics
Academic article
Lyngbakken, Magnus Nakrem; Røsjø, Helge; Holmen, Oddgeir; Nygård, Ståle; Dalen, Håvard; Hveem, Kristian. (2016) Gender, High-Sensitivity Troponin I, and the Risk of Cardiovascular Events (from the Nord-Trøndelag Health Study). American Journal of Cardiology
Academic article
Ried, Janina S.; Jeff, Janina M.; Chu, Audrey Y.; Bragg-Gresham, Jennifer L.; Dongen, Jenny Van; Huffman, Jennifer E.. (2016) A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape. Nature Communications
Academic article
Ehret, Georg B.; Ferreira, Teresa; Chasman, Daniel I.; Jackson, Anne U.; Schmidt, Ellen M.; Johnson, Toby. (2016) The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals. Nature Genetics
Academic article
Holmen, Jostein; Holmen, Turid Lingaas; Tverdal, Aage; Holmen, Oddgeir; Sund, Erik Reidar; Midthjell, Kristian. (2016) Blood pressure changes during 22-year of follow-up in large general population - the HUNT Study, Norway. BMC Cardiovascular Disorders
Academic article
Løset, Mari; Modalsli, Ellen Heilmann; Snekvik, Ingrid; Zhou, Wei; Chu, Yunhan; Gabrielsen, Maiken Elvestad. (2016) HUNTing for Genes that Affect Psoriasis in ~2,900 Cases and ~48,000 Controls. Forum for Nordic Dermato-Venereology
Abstract
Zayats, Tetyana; Jacobsen, Kaya Kvarme; Kleppe, Rune; Jacob, CP; Kittel-Schneider, Sarah; Ribases, Marta. (2016) Exome chip analyses in adult attention deficit hyperactivity disorder. Translational Psychiatry
Academic article

2015

Shungin, Dmitry; Winkler, Thomas W.; Croteau-Chonka, Damien C.; Ferreira, Teresa; Locke, Adam E.; Mägi, Reedik. (2015) New genetic loci link adipose and insulin biology to body fat distribution. Nature
Academic article
Gaulton, Kyle J.; Ferreira, Teresa; Lee, Yeji; Raimondo, Anne; Mägi, Reedik; Reschen, Michael E.. (2015) Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci. Nature Genetics
Academic article
Feng, Shuang; Pistis, Giorgio; Zhang, He; Zawistowski, Matthew; Mulas, Antonella; Zoledziewska, Magdalena. (2015) Methods for association analysis and meta-analysis of rare variants in families. Genetic Epidemiology
Academic article
Tang, Clara S.; Zhang, He; Cheung, Chloe Y.Y.; Xu, Ming; Ho, Jenny C.Y.; Zhou, Wei. (2015) Exome-wide association analysis reveals novel coding sequence variants associated with lipid traits in Chinese. Nature Communications
Academic article
Locke, Adam E.; Kahali, Bratati; Berndt, Sonja I.; Justice, Anne E.; Pers, Tune H.; Day, Felix R.. (2015) Genetic studies of body mass index yield new insights for obesity biology. Nature
Academic article
Omland, Torbjørn; Lemos, James A De; Holmen, Oddgeir; Dalen, Håvard; Benth, Jurate Saltyte; Nygård, Ståle. (2015) Impact of sex on the prognostic value of high-sensitivity cardiac troponin I in the general population: The HUNT study. Clinical Chemistry
Academic article

2014

Wood, Andrew R.; Esko, Tonu; Yang, Jian; Vedantam, Sailaja; Pers, Tune H; Gustafsson, Stefan. (2014) Defining the role of common variation in the genomic and biological architecture of adult human height. Nature Genetics
Academic article
Liu, Dajiang J.; Peloso, Gina M.; Zhan, Xiaowei; Holmen, Oddgeir; Zawistowski, Matthew; Feng, Shuang. (2014) Meta-analysis of gene-level tests for rare variant association. Nature Genetics
Academic article
Holmen, Oddgeir; Zhang, He; Zhou, Wei; Schmidt, Ellen; Hovelson, Daniel H; Langhammer, Arnulf. (2014) No large-effect low-frequency coding variation found for myocardial infarction. Human Molecular Genetics
Academic article
Kvehaugen, Anne Stine; Melien, Øyvind; Holmen, Oddgeir; Laivuori, Hannele; Dechend, Ralf; Staff, Anne Cathrine. (2014) Hypertension after preeclampsia and relation to the C1114G polymorphism (rs4606) in RGS2: Data from the Norwegian HUNT2 study. BMC Medical Genetics
Academic article
Mahajan, Anubha; Go, Min Jin; Zhang, Weihua; Below, Jennifer E; Gaulton, Kyle J; Ferreira, Teresa. (2014) Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nature Genetics
Academic article
Crosby, Jacy; Peloso, Gina M; Auer, Paul L; Crosslin, David R; Stitziel, Nathan O; Lange, Leslie A. (2014) Loss-of-function mutations in APOC3, triglycerides, and coronary disease. New England Journal of Medicine
Academic article
Lange, LA; Hu, Y; Zhang, H; Xue, C; Schmidt, EM; Tang, ZZ. (2014) Whole-exome sequencing identifies rare and low-frequency coding variants associated with LDL cholesterol. American Journal of Human Genetics
Academic article
Holmen, Oddgeir; Zhang, He; Fan, Yanbo; Hovelson, Daniel H; Schmidt, EM; Zhou, Wei. (2014) Systematic evaluation of coding variation identifies a candidate causal variant in TM6SF2 influencing total cholesterol and myocardial infarction risk. Nature Genetics
Academic article

2013

Wu, Y; Waite, LL; Jackson, Anne U.; Sheu, WHH; Buyske, Steven; Absher, D. (2013) Trans-Ethnic Fine-Mapping of Lipid Loci Identifies Population-Specific Signals and Allelic Heterogeneity That Increases the Trait Variance Explained. PLoS Genetics
Academic article
Kvehaugen, Anne Stine; Melien, Øyvind; Holmen, Oddgeir; Laivuori, Hannele; Øian, Pål; Andersgaard, Alice Beathe. (2013) Single Nucleotide Polymorphisms in G Protein Signaling Pathway Genes in Preeclampsia. Hypertension
Academic article

2012

Morris, AP; Voight, BF; Teslovich, TM; Ferreira, T; Segre, AV; Steinthorsdottir, V. (2012) Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nature Genetics
Academic article

2011

Chan, Y; Holmen, Oddgeir; Dauber, A; Vatten, Lars Johan; Havulinna, AS; Skorpen, Frank. (2011) Common variants show predicted polygenic effects on height in the tails of the distribution, except in extremely short individuals. PLoS Genetics
Academic article

2010

Holmen, Oddgeir; Romundstad, Solfrid; Melien, Øyvind. (2010) Association Between the G Protein beta 3 Subunit C825T Polymorphism and the Occurrence of Cardiovascular Disease in Hypertensives: The Nord-Trondelag Health Study (HUNT). American Journal of Hypertension
Academic article

Journal publications

Dand, Nick; Stuart, Philip E.; Bowes, John; Ellinghaus, David; Nititham, Joanne; Saklatvala, Jake R.. (2025) GWAS meta-analysis of psoriasis identifies new susceptibility alleles impacting disease mechanisms and therapeutic targets. Nature Communications
Academic article
Helgeland, Øyvind; Vaudel, Marc; Sole-Navais, Pol; Flatley, Christopher; Juodakis, Julius; Bacelis, Jonas. (2024) Correction to: Characterization of the genetic architecture of infant and early childhood body mass index (Nature Metabolism, (2022), 4, 3, (344-358), 10.1038/s42255-022-00549-1). Nature Metabolism
Errata
Lagou, Vasiliki; Jiang, Longda; Ulrich, Anna; Zudina, Liudmila; González, Karla Sofia Gutiérrez; Balkhiyarova, Zhanna. (2023) GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification. Nature Genetics
Academic article
Brumpton, Ben Michael; Graham, Sarah; Surakka, Ida; Skogholt, Anne Heidi; Løset, Mari; Fritsche, Lars G.. (2022) The HUNT study: A population-based cohort for genetic research. Cell Genomics
Academic article
Bahrami, Shahram; Hindley, Guy Frederick Lanyon; Winsvold, Bendik K S; O'Connell, Kevin Sean; Frei, Oleksandr; Shadrin, Alexey. (2022) Dissecting the shared genetic basis of migraine and mental disorders using novel statistical tools. Brain
Academic article
Helgeland, Øyvind; Vaudel, Marc; Sole-Navais, Pol; Flatley, Christopher; Juodakis, Julius; Bacelis, Jonas. (2022) Characterization of the genetic architecture of infant and early childhood body mass index. Nature Metabolism
Academic article
Freidin, Maxim B.; Tsepilov, Yakov A.; Stanaway, Ian B.; Meng, Weihua; Hayward, Caroline; Smith, Blair H.. (2021) Sex- and age-specific genetic analysis of chronic back pain. Pain
Academic article
Nielsen, Jonas Bille; Rom, Oren; Surakka, Ida; Graham, Sarah E.; Zhou, Wei; Roychowdhury, Tanmoy. (2020) Loss-of-function genomic variants highlight potential therapeutic targets for cardiovascular disease. Nature Communications
Academic article
Rounge, Trine Ballestad; Lauritzen, Marianne; Erlandsen, Sten Even; Langseth, Hilde; Holmen, Oddgeir Lingaas; Gislefoss, Randi Elin. (2019) Ultralow amounts of DNA from long-term archived serum samples produce quality genotypes. European Journal of Human Genetics
Academic article
Lyngbakken, Magnus; Røsjø, Helge; Holmen, Oddgeir Lingaas; Dalen, Håvard; Hveem, Kristian; Omland, Torbjørn. (2019) Temporal changes in cardiac troponin i are associated with risk of cardiovascular events in the general population: The Nord-Trøndelag health study. Clinical Chemistry
Academic article
Justice, Anne E.; Karaderi, Tugce; Highland, Heather M.; Young, Kristin L.; Graff, Mariaelisa; Lu, Yingchang. (2019) Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution. Nature Genetics
Academic article
Turcot, Valérie; Lu, Yingchang; Highland, Heather M.; Schurmann, Claudia; Justice, Anne E.; Fine, Rebecca S.. (2019) Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity (Nature Genetics, (2018), 50, 1, (26-41), 10.1038/s41588-017-0011-x). Nature Genetics
Errata
Helgeland, Øyvind; Vaudel, Marc; Juliusson, Petur Benedikt; Holmen, Oddgeir Lingaas; Juodakis, Julius; Bacelis, Jonas. (2019) Genome-wide association study reveals dynamic role of genetic variation in infant and early childhood growth. Nature Communications
Academic article
Løset, Mari; Modalsli, Ellen Heilmann; Snekvik, Ingrid; Solvin, Åshild Øksnevad; Holmen, Oddgeir Lingaas; Gabrielsen, Maiken Elvestad. (2018) 743 HUNTing for genes that affect inflammatory skin disease in 4,071 cases and 40,430 controls. Journal of Investigative Dermatology
Abstract
Turcot, Valérie; Helgeland, Øyvind; Holmen, Oddgeir Lingaas; Johansson, Stefan; Njølstad, Pål Rasmus; Loos, Ruth J.F.. (2018) Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. Nature Genetics
Errata
Sigurdardottir, Fjola Dogg; Lyngbakken, Magnus Nakrem; Holmen, Oddgeir Lingaas; Dalen, Håvard; Hveem, Kristian; Røsjø, Helge. (2018) Relative prognostic value of cardiac troponin I and C-reactive protein in the general population (from the Nord-Trøndelag Health [HUNT] Study). American Journal of Cardiology
Academic article
Nielsen, Jonas B.; Fritsche, Lars; Zhou, Wei; Teslovich, Tanya M.; Holmen, Oddgeir Lingaas; Gustafsson, Stefan. (2018) Genome-wide Study of Atrial Fibrillation Identifies Seven Risk Loci and Highlights Biological Pathways and Regulatory Elements Involved in Cardiac Development. American Journal of Human Genetics
Academic article
Nielsen, Jonas B.; Thorolfsdottir, Rosa B.; Fritsche, Lars; Zhou, Wei; Skov, Morten W.; Graham, Sarah E.. (2018) Biobank-driven genomic discovery yields new insight into atrial fibrillation biology. Nature Genetics
Academic article
Thorolfsdottir, Rosa B; Sveinbjornsson, Gardar; Sulem, Patrick; Nielsen, Jonas B.; Jonsson, Stefan; Halldorsson, Gisli H. (2018) Coding variants in RPL3L and MYZAP increase risk of atrial fibrillation. Communications Biology
Academic article
Turcot, Valérie; Lu, Yingchang; Highland, Heather M.; Schurmann, Claudia; Justice, Anne E.; Fine, Rebecca S.. (2018) Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. Nature Genetics
Academic article
Gusarova, Viktoria; O'Dushlaine, Colm; Teslovich, Tanya M.; Benotti, Peter N.; Mirshahi, Tooraj; Gottesman, Omri. (2018) Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes. Nature Communications
Academic article
Webb, Thomas R.; Erdmann, Jeanette; Stirrups, Kathleen E.; Stitziel, Nathan O.; Masca, Nicholas G.D.; Jansen, Henning. (2017) Systematic evaluation of pleiotropy identifies 6 further loci associated with coronary artery disease. Journal of the American College of Cardiology
Academic article
Justice, Anne E.; Winkler, Thomas W.; Feitosa, Mary F.; Graff, Misa; Fisher, Virginia A.; Young, Kristin. (2017) Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits. Nature Communications
Academic article
Ferreira, Manuel A.; Vonk, Judith M; Baurecht, Hansjörg; Marenholz, Ingo; Tian, Chao; Hoffman, Joshua D. (2017) Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology. Nature Genetics
Academic article
Liu, Dajiang J.; Peloso, Gina M.; Yu, Haojie; Butterworth, Adam S.; Wang, Xiao; Mahajan, Anubha. (2017) Exome-wide association study of plasma lipids in &gt;300,000 individuals. Nature Genetics
Academic article
Graff, Mariaelisa; Scott, Robert A.; Justice, Anne E.; Young, Kristin L.; Feitosa, Mary F.; Barata, Llilda. (2017) Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults. PLoS Genetics
Academic article
Zhou, Wei; Fritsche, Lars; Das, Sayantan; Zhang, He; Nielsen, Jonas B.; Holmen, Oddgeir Lingaas. (2017) Improving power of association tests using multiple sets of imputed genotypes from distributed reference panels. Genetic Epidemiology
Academic article
Stitziel, Nathan O.; Stirrups, Kathleen E.; Masca, Nicholas G.D.; Erdmann, Jeanette; Ferrario, Paola G.; König, Inke R.. (2016) Coding variation in ANGPTL4, LPL, and SVEP1 and the risk of coronary disease. New England Journal of Medicine
Academic article
Surendran, Praveen; Drenos, Fotios; Young, Robin; Warren, Helen; Cook, James P.; Manning, Alisa K.. (2016) Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension. Nature Genetics
Academic article
Lyngbakken, Magnus Nakrem; Røsjø, Helge; Holmen, Oddgeir; Nygård, Ståle; Dalen, Håvard; Hveem, Kristian. (2016) Gender, High-Sensitivity Troponin I, and the Risk of Cardiovascular Events (from the Nord-Trøndelag Health Study). American Journal of Cardiology
Academic article
Ried, Janina S.; Jeff, Janina M.; Chu, Audrey Y.; Bragg-Gresham, Jennifer L.; Dongen, Jenny Van; Huffman, Jennifer E.. (2016) A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape. Nature Communications
Academic article
Ehret, Georg B.; Ferreira, Teresa; Chasman, Daniel I.; Jackson, Anne U.; Schmidt, Ellen M.; Johnson, Toby. (2016) The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals. Nature Genetics
Academic article
Holmen, Jostein; Holmen, Turid Lingaas; Tverdal, Aage; Holmen, Oddgeir; Sund, Erik Reidar; Midthjell, Kristian. (2016) Blood pressure changes during 22-year of follow-up in large general population - the HUNT Study, Norway. BMC Cardiovascular Disorders
Academic article
Løset, Mari; Modalsli, Ellen Heilmann; Snekvik, Ingrid; Zhou, Wei; Chu, Yunhan; Gabrielsen, Maiken Elvestad. (2016) HUNTing for Genes that Affect Psoriasis in ~2,900 Cases and ~48,000 Controls. Forum for Nordic Dermato-Venereology
Abstract
Zayats, Tetyana; Jacobsen, Kaya Kvarme; Kleppe, Rune; Jacob, CP; Kittel-Schneider, Sarah; Ribases, Marta. (2016) Exome chip analyses in adult attention deficit hyperactivity disorder. Translational Psychiatry
Academic article
Shungin, Dmitry; Winkler, Thomas W.; Croteau-Chonka, Damien C.; Ferreira, Teresa; Locke, Adam E.; Mägi, Reedik. (2015) New genetic loci link adipose and insulin biology to body fat distribution. Nature
Academic article
Gaulton, Kyle J.; Ferreira, Teresa; Lee, Yeji; Raimondo, Anne; Mägi, Reedik; Reschen, Michael E.. (2015) Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci. Nature Genetics
Academic article
Feng, Shuang; Pistis, Giorgio; Zhang, He; Zawistowski, Matthew; Mulas, Antonella; Zoledziewska, Magdalena. (2015) Methods for association analysis and meta-analysis of rare variants in families. Genetic Epidemiology
Academic article
Tang, Clara S.; Zhang, He; Cheung, Chloe Y.Y.; Xu, Ming; Ho, Jenny C.Y.; Zhou, Wei. (2015) Exome-wide association analysis reveals novel coding sequence variants associated with lipid traits in Chinese. Nature Communications
Academic article
Locke, Adam E.; Kahali, Bratati; Berndt, Sonja I.; Justice, Anne E.; Pers, Tune H.; Day, Felix R.. (2015) Genetic studies of body mass index yield new insights for obesity biology. Nature
Academic article
Omland, Torbjørn; Lemos, James A De; Holmen, Oddgeir; Dalen, Håvard; Benth, Jurate Saltyte; Nygård, Ståle. (2015) Impact of sex on the prognostic value of high-sensitivity cardiac troponin I in the general population: The HUNT study. Clinical Chemistry
Academic article
Wood, Andrew R.; Esko, Tonu; Yang, Jian; Vedantam, Sailaja; Pers, Tune H; Gustafsson, Stefan. (2014) Defining the role of common variation in the genomic and biological architecture of adult human height. Nature Genetics
Academic article
Liu, Dajiang J.; Peloso, Gina M.; Zhan, Xiaowei; Holmen, Oddgeir; Zawistowski, Matthew; Feng, Shuang. (2014) Meta-analysis of gene-level tests for rare variant association. Nature Genetics
Academic article
Holmen, Oddgeir; Zhang, He; Zhou, Wei; Schmidt, Ellen; Hovelson, Daniel H; Langhammer, Arnulf. (2014) No large-effect low-frequency coding variation found for myocardial infarction. Human Molecular Genetics
Academic article
Kvehaugen, Anne Stine; Melien, Øyvind; Holmen, Oddgeir; Laivuori, Hannele; Dechend, Ralf; Staff, Anne Cathrine. (2014) Hypertension after preeclampsia and relation to the C1114G polymorphism (rs4606) in RGS2: Data from the Norwegian HUNT2 study. BMC Medical Genetics
Academic article
Mahajan, Anubha; Go, Min Jin; Zhang, Weihua; Below, Jennifer E; Gaulton, Kyle J; Ferreira, Teresa. (2014) Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nature Genetics
Academic article
Crosby, Jacy; Peloso, Gina M; Auer, Paul L; Crosslin, David R; Stitziel, Nathan O; Lange, Leslie A. (2014) Loss-of-function mutations in APOC3, triglycerides, and coronary disease. New England Journal of Medicine
Academic article
Lange, LA; Hu, Y; Zhang, H; Xue, C; Schmidt, EM; Tang, ZZ. (2014) Whole-exome sequencing identifies rare and low-frequency coding variants associated with LDL cholesterol. American Journal of Human Genetics
Academic article
Holmen, Oddgeir; Zhang, He; Fan, Yanbo; Hovelson, Daniel H; Schmidt, EM; Zhou, Wei. (2014) Systematic evaluation of coding variation identifies a candidate causal variant in TM6SF2 influencing total cholesterol and myocardial infarction risk. Nature Genetics
Academic article
Wu, Y; Waite, LL; Jackson, Anne U.; Sheu, WHH; Buyske, Steven; Absher, D. (2013) Trans-Ethnic Fine-Mapping of Lipid Loci Identifies Population-Specific Signals and Allelic Heterogeneity That Increases the Trait Variance Explained. PLoS Genetics
Academic article
Kvehaugen, Anne Stine; Melien, Øyvind; Holmen, Oddgeir; Laivuori, Hannele; Øian, Pål; Andersgaard, Alice Beathe. (2013) Single Nucleotide Polymorphisms in G Protein Signaling Pathway Genes in Preeclampsia. Hypertension
Academic article
Morris, AP; Voight, BF; Teslovich, TM; Ferreira, T; Segre, AV; Steinthorsdottir, V. (2012) Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nature Genetics
Academic article
Chan, Y; Holmen, Oddgeir; Dauber, A; Vatten, Lars Johan; Havulinna, AS; Skorpen, Frank. (2011) Common variants show predicted polygenic effects on height in the tails of the distribution, except in extremely short individuals. PLoS Genetics
Academic article
Holmen, Oddgeir; Romundstad, Solfrid; Melien, Øyvind. (2010) Association Between the G Protein beta 3 Subunit C825T Polymorphism and the Occurrence of Cardiovascular Disease in Hypertensives: The Nord-Trondelag Health Study (HUNT). American Journal of Hypertension
Academic article

Report

Bianchini, Federico; Birkeland, Even; Bösl, Korbinian; Gade, Alexandra; Holmen, Oddgeir Lingaas; Hu, Xian. (2021) BioMedData Deliverable D2.1 - Report on data management plan needs/gaps. Zenodo Zenodo
Report

Teaching

Courses

MOL3009 - Biobanking

Outreach

2018

Poster

Rostami, Sina; Hoff, Mari; Brown, Matthew A.; Hveem, Kristian; Holmen, Oddgeir Lingaas; Videm, Vibeke. (2018) Risk association for ankylosing spondylitis using a genetic risk score combining 110 SNPs of genome-wide significance in the population-based HUNT study. EULAR Annual European Congress of Rheumatology , Amsterdam 2018-06-13 - 2018-06-16

2017

Poster

Lyngbakken, Magnus Nakrem; Røsjø, Helge; Holmen, Oddgeir Lingaas; Dalen, Håvard; Hveem, Kristian; Omland, Torbjørn. (2017) Temporal Changes in Cardiac Troponin I and Risk of Cardiovascular Events in the General Population: The Nord-Trøndelag Health Study. American Heart Association Scientific Sessions 2017 , Anaheim 2017-11-11 - 2017-11-15

2016

Academic lecture

Løset, Mari; Modalsli, Ellen Heilmann; Snekvik, Ingrid; Zhou, Wei; Chu, Yunhan; Gabrielsen, Maiken Elvestad. (2016) HUNTing for Genes that Affect Psoriasis in ~2,900 Cases and ~48,000 Controls. The 33rd Nordic Congress of Dermatology and Venereolgy 2016-04-27 - 2016-04-29
Poster

Lyngbakken, Magnus Nakrem; Røsjø, Helge; Holmen, Oddgeir Lingaas; Dalen, Håvard; Hveem, Kristian; Omland, Torbjørn. (2016) Impact of smoking on circulating troponin I concentrations and cardiovascular events in the general population: The HUNT Study. ESC2016 , Roma 2016-08-27 -
Academic lecture

Solvin, Åshild Øksnevad; Modalsli, Ellen Heilmann; Snekvik, Ingrid; Gabrielsen, Maiken Elvestad; Holmen, Oddgeir Lingaas; Saunes, Marit. (2016) Establishing a biobank for gene expression studies of psoriasis. Frampeik , Bergen 2016-10-21 - 2016-10-23

Språkvelger

Oddgeir Lingaas Holmen