Rahmi Lale

Adjunct Assoc. Prof. / Researcher Department of Biotechnology Faculty of Natural Sciences and Technology

+47 73598678
Gløshaugen, Realfagbygget Del B 2. etasje: Rom B2-128

Background and activities


I am working as Adjunct Assoc. Prof. / researcher at the Department of Biotechnology, NTNU. My main research focus areas are bacterial transcriptional and translational regulation, biological tools development, and synthetic biology. Model organisms that I work with are: Escherichia coli, Pseudomonas putida KT2440, psychrophilic Pseudomonas, Psychrobacter spp. and Synechococcus sp. PCC 7002.


EU - H2020 - Advanced toolbox for rapid and cost-effective functional metagenomic screening - microbiology meets microfluidics. Involved as PI

PhotoSynLab - We practice open science

For curious minds, more information can be found on our lab website on what do we do: www.photosynlab.org

iGEM 2016

More information will follow!


TBT4165 - System Biology and Biological Networks
TBT4505 - Biotechnology -  Specialization Course - Bioinformatics

Scientific profile

       Google Scholar


  • 2016

Beal J, Haddock-Angelli T, Gershater M, de Mora K, Lizarazo M, Hollenhorst J, et al. Reproducibility of fluorescent expression from engineered biological constructs in E. coli. PLoS ONE.

Arnfinnsdottir, NB., Bjørkøy, A., Lale, R., Sletmoen, M. Heterogeneity in GFP expression in isogenic populations of P. putida KT2440 investigated using flow cytometry and bacterial microarrays. RSC Advances

Moghadam MM, Albersmeier A,Winkler A, Cimmino L, Rise K, Hohmann-Marriott FM, Kalinowski J, Rückert C, Wentzel A, Lale, R. Isolation and genome sequencing of four Arctic marine Psychrobacter strains exhibiting multicopper oxidase activity. BMC Genomics.

  • 2015
  • 2014
Petrov, V., Balasubramaniam, S., Lale, R., Moltchanov, D., Lio’, P., Koucheryavy, Y. Forward and Reverse Coding for Chromosome Transfer in Bacterial Nanonetworks. Nano Communication Networks.
Strand, TA., Lale, R., Degnes, KF., Lando, M. and Valla, S. A new and improved host-independent plasmid system for RK2-based conjugal transfer. PLoS ONE.
DNA Cloning and Assembly Methods. Methods in Molecular Biology, editors Rahmi Lale and Svein Valla. Volume 1116, XI, 303 p. Springer Protocols, Humana Press.
Røkke, G., Korvald, E., Pahr, J., Øyås, O., and Lale, R. BioBrick assembly standards and techniques and associated software tools. DNA Cloning and Assembly Methods. Methods in Molecular Biology, editors by Lale, R. and Valla, S. Volume 1116, 2014, pp 1-24 Springer Protocols, Humana Press.
  • 2013
Zwick, F., Lale, R. and Valla, S. Combinatorial engineering for heterologous gene expression. Bioengineered.
Balzer, S., Kucharova, V., Megerle, J., Lale, R., Brautaset, T., Valla, S. A comparative analysis of the properties of regulated promoter systems commonly used for recombinant gene expression in Escherichia coli. Microbial Cell Factories, 12:26.
  • 2012
Almaas, E., Bruheim, P., Lale, R. and Valla, S. Dynamics and robustness of metabolic networks: A systems biology review of Escherichia coli metabolism. Systems Microbiology: Current Topics and Applications. ISBN: 978-1-908230-02-7.
  • 2011
Aakvik, T., Lale, R., Liles, M. and Valla, S. Metagenomic libraries for functional screening, Ch 22. Handbook of Molecular Microbial Ecology I: Metagenomics and Complementary Approaches. Ed. de Bruijn, F.J.
Lale, R., Brautaset, T.and Valla, S. Broad-host-range plasmid vectors for gene expression in bacteria. Met. Mol. Biol. 765, Part 3, 327-343.
Lale, R., Berg, L., Stüttgen, F., Netzer, R., Stafsnes, M., Brautaset, T., Aune, T.E.V. and Valla. S. Continuous control of the flow in biochemical pathways through 5'-UTR sequence modifications in mRNA expressed from the broad-host-range Pm promoter. Appl. Env. Mircobiol. 77: 2648-2655.
  • 2010
Aune, T. E. V., Bakke, I., Drabløs, F., Lale, R., Brautaset, T. and Valla, S. Directed evolution of the transcription factor XylS for development of improved expression systems. Microb. Biotechnol. 3:1, 38–47.
  • 2009
Brautaset, T., Lale, R. and Valla, S. Positively regulated bacterial expression systems. Microb. Biotechnol. 2 (1), 15-30.
  • 2008
Bar, N. S. and Lale, R. Modeling and control of the protein synthesis process in eukaryotic cells. 47th IEEE Proceedings: Conference on Decision and Control (CDC) 179-184.
  • 2007
Lale, R., Tukel, C. and Akcelik, M. Protein profile and plasmid content of Lactococcus lactis subsp lactis LL5Z and Lactococcus lactis subsp cremoris LC79 strains under several stress conditions. T. J. Vet. An. Sci. 31(4), 247-252.

Scientific, academic and artistic work

Displaying a selection of activities. See all publications in the database

Journal publications


  • Valla, Svein; Lale, Rahmi. (2014) DNA Cloning and Assembly Methods. Humana Press. 2014. ISBN 978-1-62703-763-1. Methods in Molecular Biology (1116).

Part of book/report

  • Røkke, Gunvor; Korvald, Eirin; Pahr, Jarle; Øyås, Ove; Lale, Rahmi. (2014) BioBrick Assembly Standards and Techniques and Associated Software Tools. DNA Cloning and Assembly Methods.
  • Almaas, Eivind; Bruheim, Per; Lale, Rahmi; Valla, Svein. (2012) Dynamics and robustness of metabolic networks: A systems biology review of Escherichia coli metabolism. Systems Microbiology - Current Topics and Applications.
  • Aakvik, Trine; Lale, Rahmi; Liles, Mark R.; Valla, Svein. (2011) Metagenomic Libraries for Functional Screening. Handbook of Molecular Microbial Ecology I - Metagenomics and Complementary Approaches.
  • Lale, Rahmi; Brautaset, Trygve; Valla, Svein. (2011) Broad-Host-Range Plasmid Vectors for Gene Expression in Bacteria. Strain Engineering - Methods and Protocols, Methods in Molecular Biology.