Background and activities


I am working as a researcher at the Department of Biotechnology, NTNU. My main research focus areas are bacterial transcriptional and translational regulation, synthetic biology/metabolic engineering and metagenome/biodiscovery.

I have been working with various organisms including E. coli, mesophilic and psychrophilic Pseudomonas sp., Streptomyces sp, Shewanella sp., Pseudoalteromonas sp., Synechocystis sp., lactic acid bacteria, and yeast. I am also one of the instructors of the iGEM (International Genetically Engineered Machine) competition NTNU-Trondheim team.

PhotoSynLab - We practice open science

For the curious minds, more information can be found here on what we do:

iGEM 2015

We are joining to the competition this year as well. More information will follow!

TScientific profile

       Google Scholar


  • 2014
Petrov, V., Balasubramaniam, S., Lale, R., Moltchanov, D., Lio’, P., Koucheryavy, Y. Forward and Reverse Coding for Chromosome Transfer in Bacterial Nanonetworks. Nano Communication Networks.
Strand, TA., Lale, R., Degnes, KF., Lando, M. and Valla, S. A new and improved host-independent plasmid system for RK2-based conjugal transfer. PLoS ONE.
DNA Cloning and Assembly Methods. Methods in Molecular Biology, edited by Rahmi Lale and Svein Valla. Volume 1116, XI, 303 p. Springer Protocols, Humana Press.
Røkke, G., Korvald, E., Pahr, J., Øyås, O., and Lale, R. BioBrick assembly standards and techniques and associated software tools. DNA Cloning and Assembly Methods. Methods in Molecular Biology, edited by Lale, R. and Valla, S. Volume 1116, 2014, pp 1-24 Springer Protocols, Humana Press.
  • 2013
Zwick, F., Lale, R. and Valla, S. Combinatorial engineering for heterologous gene expression. Bioengineered.
Balzer, S., Kucharova, V., Megerle, J., Lale, R., Brautaset, T., Valla, S. A comparative analysis of the properties of regulated promoter systems commonly used for recombinant gene expression in Escherichia coli. Microbial Cell Factories, 12:26.
  • 2012
Almaas, E., Bruheim, P., Lale, R. and Valla, S. Dynamics and robustness of metabolic networks: A systems biology review of Escherichia coli metabolism. Systems Microbiology: Current Topics and Applications. ISBN: 978-1-908230-02-7.
  • 2011
Aakvik, T., Lale, R., Liles, M. and Valla, S. Metagenomic libraries for functional screening, Ch 22. Handbook of Molecular Microbial Ecology I: Metagenomics and Complementary Approaches. Ed. de Bruijn, F.J.
Lale, R., Brautaset, T.and Valla, S. Broad-host-range plasmid vectors for gene expression in bacteria. Met. Mol. Biol. 765, Part 3, 327-343.
Lale, R., Berg, L., Stüttgen, F., Netzer, R., Stafsnes, M., Brautaset, T., Aune, T.E.V. and Valla. S. Continuous control of the flow in biochemical pathways through 5'-UTR sequence modifications in mRNA expressed from the broad-host-range Pm promoter. Appl. Env. Mircobiol. 77: 2648-2655.
  • 2010
Aune, T. E. V., Bakke, I., Drabløs, F., Lale, R., Brautaset, T. and Valla, S. Directed evolution of the transcription factor XylS for development of improved expression systems. Microb. Biotechnol. 3:1, 38–47.
  • 2009
Brautaset, T., Lale, R. and Valla, S. Positively regulated bacterial expression systems. Microb. Biotechnol. 2 (1), 15-30.
  • 2008
Bar, N. S. and Lale, R. Modeling and control of the protein synthesis process in eukaryotic cells. 47th IEEE Proceedings: Conference on Decision and Control (CDC) 179-184.
  • 2007
Lale, R., Tukel, C. and Akcelik, M. Protein profile and plasmid content of Lactococcus lactis subsp lactis LL5Z and Lactococcus lactis subsp cremoris LC79 strains under several stress conditions. T. J. Vet. An. Sci. 31(4), 247-252.

Scientific, academic and artistic work

Displaying a selection of activities. See all publications in the database

Journal publications


  • Valla, Svein; Lale, Rahmi. (2014) DNA Cloning and Assembly Methods. Humana Press. 2014. ISBN 978-1-62703-763-1. Methods in Molecular Biology (1116).

Part of book/report

  • Røkke, Gunvor; Korvald, Eirin; Pahr, Jarle; Øyås, Ove; Lale, Rahmi. (2014) BioBrick Assembly Standards and Techniques and Associated Software Tools. DNA Cloning and Assembly Methods.
  • Almaas, Eivind; Bruheim, Per; Lale, Rahmi; Valla, Svein. (2012) Dynamics and robustness of metabolic networks: A systems biology review of Escherichia coli metabolism. Systems Microbiology - Current Topics and Applications.
  • Aakvik, Trine; Lale, Rahmi; Liles, Mark R.; Valla, Svein. (2011) Metagenomic Libraries for Functional Screening. Handbook of Molecular Microbial Ecology I - Metagenomics and Complementary Approaches.
  • Lale, Rahmi; Brautaset, Trygve; Valla, Svein. (2011) Broad-Host-Range Plasmid Vectors for Gene Expression in Bacteria. Strain Engineering - Methods and Protocols, Methods in Molecular Biology.

Postal address

Department of Biotechnology Norwegian University of Science and Technology 7491 Trondheim Norway