Background for the study
Demographic data indicate tripling of the population aged 60 years or older by the year 2050. Since this age group is the fastest growing sub-population in the developed society today, research into prophylactic properties on how to achieve “healthy” aging is needed and required.
Generation 100 is the largest randomized clinical study that evaluates the effect of regular exercise training on morbidity and mortality in elderly people. Inclusion of the participants in Generation 100 started in 2012. Since then, a total of 1567 participants have been randomized to either five years of supervised exercise training, or to a control group. The exercise group was further randomized to either two weekly sessions of high intensity training, consisting of 10 minutes warm-up followed by 4x4 minute intervals at approximately 90 percent of peak heart rate, or, to moderate intensity training consisting of 50 minutes of continuous work at approximately 70 percent of peak heart rate. The control group was instructed to follow physical activity advice according to national recommendations.
Clinical examinations, as well as questionnaires, are administered to all participants at baseline, at one year (2013/2014), three year (2015/2016), and five year follow up (2017/2018). In light of the aging population, our data will contribute to an improved understanding on how older persons can achieve more, active years in better health. If proven beneficial, exercise as “medicine” will be a relatively cheap, accessible and available treatment that can benefit a large proportion of the population.
Publications from Generation 100
Absolute and relative accelerometer thresholds for determining the association between physical activity and metabolic syndrome in the older adults: The Generation-100 study. Zisko N, Nauman J, Sandbakk SB, Aspvik NP, Salvesen Ø, Carlsen T, Viken H, Ingebrigtsen JE, Wisløff U, Stensvold D. BMC Geriatr. 2017 May 16;17(1):109. doi: 10.1186/s12877-017-0497-1.
Lung function parameters improve prediction of VO2peak in an elderly population: The Generation 100 study. Hassel E, Stensvold D, Halvorsen T, Wisløff U, Langhammer A, Steinshamn S.PLoS One. 2017 Mar 20;12(3):e0174058. doi: 10.1371/journal.pone.0174058.
Sedentary Time, Cardiorespiratory Fitness, and Cardiovascular Risk Factor Clustering in Older Adults--the Generation 100 Study. Sandbakk SB, Nauman J, Zisko N, Sandbakk Ø, Aspvik NP, Stensvold D, Wisløff U. Mayo Clin Proc. 2016 Nov;91(11):1525-1534. doi: 10.1016/j.mayocp.2016.07.020.
Are Older Adults Physically Active Enough - A Matter of Assessment Method? The Generation 100 Study. Aspvik NP, Viken H, Zisko N, Ingebrigtsen JE, Wisløff U, Stensvold D. PLoS One. 2016 Nov 28;11(11):e0167012. doi: 10.1371/journal.pone.0167012.
Association between pulmonary function and peak oxygen uptake in elderly: the Generation 100 study. Hassel E ,Stensvold D, Halvorsen T, Wisløff U, Langhammer A, Steinshamn S. Respir Res. 2015 Dec 30;16:156. doi: 10.1186/s12931-015-0317-0.
Correlates of Objectively Measured Physical Activity Among Norwegian Older Adults: The Generation 100 Study. Viken H1, Aspvik NP, Ingebrigtsen JE, Zisko N, Wisløff U, Stensvold D. J Aging Phys Act. 2015 Nov 4.
Fatigue May Contribute to Reduced Physical Activity Among Older People: An Observational Study. Egerton T, Chastin SF, Stensvold D, Helbostad JL. J Gerontol A Biol Sci Med Sci. 2015 Sep 7.
New relative intensity ambulatory accelerometer thresholds for elderly men and women: the Generation 100 study. Zisko N, Carlsen T, Salvesen Ø, Aspvik NP, Ingebrigtsen JE, Wisløff U, Stensvold D. BMC Geriatr. 2015 Aug 4;15:97. doi: 10.1186/s12877-015-0093-1.
A randomised controlled study of the long-term effects of exercise training on mortality in elderly people: study protocol for the Generation 100 study. Stensvold D, Viken H, Rognmo Ø, Skogvoll E, Steinshamn S, Vatten LJ, Coombes JS, Anderssen SA, Magnussen J, Ingebrigtsen JE, Fiatarone Singh MA, Langhammer A, Støylen A, Helbostad JL, Wisløff U. BMJ Open. 2015 Feb 12;5(2):e007519. doi: 10.1136/bmjopen-2014-007519
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St. Olavs Hospital
Prinsesse Kristinas gt. 3
Akutten og Hjerte-lunge-senteret, 3rd floor
Generasjon 100 v/ Dorthe Stensvold
NTNU, Faculty of Medicine and Health Sciences
Department of Circulation and Medical Imaging
Read about Generation 100 at our blog here!