Preclinical MR/PET

Preclinical MR/PET

  • In-vivo MR imaging of disease models in small animals (mainly rats and mice).
  • In-vivo MR spectroscopy (single voxel or chemical shift imaging) in small animals.
  • In-vivo PET imaging in small animals (mice whole body and rat head).

Pre-clinical 7T BiospecMR core facility 7T biospec

  • Bruker Biospec 70/20 USR Avance III horizontal bore dedicated for MRI of small animals.
  • High performance shim and gradients: BGA-12S 660 mT/m.
  • 72mm volume resonators for 1H, 1H/13C, 1H/23Na, 1H/31P.
  • Bruker CryoProbe for mouse and baby rat head MR experiments.
  • Phased array surface coils (1H) for rat head, mouse head and mouse heart.
  • Quadrature surface coils for rat head (1H and 13C) and mouse head (1H).
  • 1H/19F Circular polarized small volume coil (Ø=40mm) for rat head/mouse body.
  • Dedicated animal beds for rats and mice with in-build water heating.
  • Life monitoring system and trigger systems for respiratory and cardiac cycle.

 PET insert

  • Bruker PET Insert Si 103 designed for total body PET of mice and rat head applications that allow simultaneous MRI acquisition.
  • Inner diameter 60 mm, 101 x 55 mm FOV.
PET / MR image
PET/MR images of xenograft bearing mice. Image courtesy: Morten Karlsen

Highlighted publications

  1. Liu, Tengzhi; Dahle, Maria Aanesland; Lystad, Mathilde Hirsum; Marignol, Laure; Redalen, Kathrine Røe; Karlsen, Morten. In vitro and in vivo characterization of [64Cu][Cu(elesclomol)] as a novel theranostic agent for hypoxic solid tumors. European Journal of Nuclear Medicine and Molecular Imaging, 2023; doi:10.1007/s00259-023-06310-4 PMID: 37382663. PMCID: PMC10547809

  2. Sulheim, Einar; Mørch, Ýrr Asbjørg; Snipstad, Sofie; Borgos, Sven Even F.; Miletic, Hrvoje; Bjerkvig, Rolf; Davies, Catharina de Lange; Åslund, Andreas. Therapeutic effect of cabazitaxel and blood-brain barrier opening in a patient-derived glioblastoma model. Nanotheranostics; 2019; Volume 3.(1) p. 103-112. doi: 10.7150/ntno.31479. PMID: 30899638. PMCID: PMC6427936

  3. Baghirov, Habib; Snipstad, Sofie; Sulheim, Einar; Berg, Sigrid; Hansen, Rune; Thorsen, Frits; Mørch, Ýrr Asbjørg; Davies, Catharina de Lange; Åslund, Andreas. Ultrasound-mediated delivery and distribution of polymeric nanoparticles in the normal brain parenchyma of a metastatic brain tumour model. PLOS ONE; 2018; Jan 16;13(1):e0191102. doi: 10.1371/journal.pone.0191102 PMID: 29338016. PMCID: PMC5770053

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Contact

Contact

Contact

Visiting address

MR Core Facility
Olav Kyrres gt 11, Trondheim

Postal address

MR Core Facility
MTFS
Norwegian University of Science and Technology
Post box 8905
N-7491 Trondheim
Norway