Delivery of nanoparticles in tumour tissue and cells

Catharina Davies in the laboratory. Photo: Irene Aspli

Nanotechnology has started a new era in engineering multifunctional nanoparticles for improved cancer diagnosis and therapy, incorporating both contrast agents for imaging and therapeutics into so called theranostics NPs.

Encapsulating the drugs into nanoparticles improves the pharmacokinetics and reduces the systemic exposure due to the leaky capillaries in tumours. However, the distribution of nanoparticles in tumour tissue is heterogeneous. We are studying how ultrasound can improve the delivery of nanoparticles to cancer cells, and penetrate the blood-brain barrier thereby making it possible to treat disorder in the central nervous system.
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