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Cardiogenomics (Anja Bye Group) smacktop

Bye Group

Cardiogenomics

Anja Bye's research group looks, among other things, at whether heart disease can be predicted by small markers in the blood. The group also studies the importance of genes for fitness and health risks. On this page you can read more about ongoing projects and published results from Anja's research.


Main projects

Main projects

CorFemina

CorFemina

What's the importance of women being aware of their own risk for heart disease and having good tools to calculate risk?

Read more about CorFemina

CardioFit

CardioFit

Which genes determine our risk of lifestyle diseases? Are these the same genes that affect our physical fitness? And is there a causal link between fitness and cardiovascular disease?

Read more about CardioFit

revealCVD

revealCVD

Can the levels of small substances in the blood help us find out who is more susceptible to lifestyle diseases in the future?

Read more about revealCVD

PhD projects

PhD projects

Biomarkers, atherosclerosis and cardiovascular risk

Biomarkers, atherosclerosis and cardiovascular risk

Are the blood levels of micro-RNAs and subfractions of lipoproteins associated with dangerous plaques in the coronary arteries of heart patients? And can these biomarkers help us reveal who is at high risk of a heart attack?

Read more about the PhD project

COPING

COPING

How can genetic markers of aerobic capacity and resting heart rate help us better predict who is at high risk for cardiovascular disease?

Read more about the PhD project

CardioFit PhD

CardioFit PhD

What other health conditions are linked to our fitness genes? And could overproduction of one fitness gene lead to better heart function?

Read more about the PhD project

Exercise, microNRAs and atherosclerosis

Exercise, microNRAs and atherosclerosis

Does endurance exercise change the levels of microRNAs in the blood after a heart attack? And how do these changes affect the composition of the plaque in the blood vessels of the heart?

Read more about the PhD project

Master's projects

Master's projects

Endurance exercise in lipedema

Endurance exercise in lipedema

Does endurance training lead to less pain and a better quality of life for women with lipedema?

Read more about the master's project

Exercise and lipids in overweight adolescents

Exercise and lipids in overweight adolescents

Which exercise intensity has the greatest effect in terms of the lipid profile in overweight or obese adolescents?

Read more about the master's project

Lipoproteins and coronary plaques

Lipoproteins and coronary plaques

Do the levels of various fatty substances in the blood reveal which heart patients have the most severe formation of plaques in the coronary arteries?

Read more about the master's project

Exercise and lipoprotein profile

Exercise and lipoprotein profile

What can the levels of 99 different lipoproteins in the blood tell us about the aerobic fitness of healthy adults?

Read more about the master's project

Machine learning and prediction of cardiovascular disease

Machine learning and prediction of cardiovascular disease

Can classification methods from statistical learning give us better models to predict who will be affected by cardiovascular disease?

Read more about the master's project

Exercise, genetics and cardiovascular disease

Exercise, genetics and cardiovascular disease

Can exercise affect our genetic risk of cardiovascular disease?

Read more about the master's project

person-portlet

Research group leader

Anja Bye
Professor and head of research group in Cardiogenomics
anja.bye@ntnu.no
+4793232057

person-portlet

Master's students

Scientific publications from Cardiogenomics (Anja Bye Group)

List of scientific publications from Cardiogenomics (Anja Bye Group)

2024:

Nordeidet, A. N., Klevjer, M., Øvretveit, K., Madssen, E., Wisløff, U., Brumpton, B. M., & Bye, A. Sex-specific and polygenic effects underlying resting heart rate and associated risk of cardiovascular diseaseEuropean Journal of Preventive Cardiology.

2023:

Klevjer, M., Rasheed, H., Romundstad, P. R., Madssen, E., Brumpton, B. M., & Bye, A. (2023). Insight into the relationship between resting heart rate and atrial fibrillation: A Mendelian Randomization study. Europace25(10), euad292.

Tynkkynen, N. P., Törmäkangas, T., Palviainen, T., Hyvärinen, M., Klevjer, M., Joensuu, L., Kaprio, J., Bye, Anja & Sillanpää, E. (2023). Associations of polygenic inheritance of physical activity with aerobic fitness, cardiometabolic risk factors and diseases: the HUNT StudyEuropean Journal of Epidemiology, 1-14.

Nordeidet, A. N., Klevjer, M., Wisløff, U., Langaas, M., & Bye, A. (2023) Exploring shared genetics between maximal oxygen uptake and disease: the HUNT studyPhysiological Genomics

Sæther, J. C., Vesterbekkmo, E. K., Taraldsen, M. D., Gigante, B., Follestad, T., Røsjø, H. R., Omland, T., Wiseth, R., Madssen, E., & Bye, A. (2023). Associations between circulating microRNAs and lipid-rich coronary plaques measured with near-infrared spectroscopyScientific Reports13(1), 7580.

Sperstad, S. B., Sæther, J. C., Klevjer, M., Giskeødegård, G. F., Bathen, T. F., Røsbjørgen, R., Dalen, H., & Bye, A. (2023). Lipoprotein subfraction profiling in the search of new risk markers for myocardial infarction: The HUNT study. Plos one18(5), e0285355.

Sæther, J. C., Vesterbekkmo, E. K., Gigante, B., Giskeødegård, G. F., Bathen, T. F., Follestad, T., Wiseth, R., Madssen, E., & Bye, A. (2023). The association between circulating lipoprotein subfractions and lipid content in coronary atheromatous plaques assessed by near-infrared spectroscopyIJC Heart & Vasculature46, 101215.

Klevjer, M., Nordeidet, A. N., & Bye, A. (2023). The genetic basis of exercise and cardiorespiratory fitness–Relation to cardiovascular diseaseCurrent Opinion in Physiology, 100649.

2022:

Sæther, J. C., Klevjer, M., Giskeødegård, G. F., Bathen, T. F., Gigante, B., Gjære, S., Myhra, M., Vesterbekkmo, E. K., Wiseth, R., Madssen, E., & Bye, A. (2022). Small LDL subfractions are associated with coronary atherosclerosis despite no differences in conventional lipidsPhysiological Genomics.

Benegiamo, G., Bou Sleiman, M., Wohlwend, M., Rodríguez-López, S., Goeminne, L. J., Laurila, P. P., Kleiver, M., Salonen, M. K., Lahti, J., Jha, P., Cogliati, S., Enriquez, J. A., Brumpton, B. M., Bye, A., Eriksson, J. G.,& Auwerx, J. (2022). COX7A2L genetic variants determine cardiorespiratory fitness in mice and humanNature Metabolism, 1-16.

Klevjer, M., Nordeidet, A. N., Hansen, A. F., Madssen, E., Wisløff, U., Brumpton, B. M., & Bye, A. Genome-wide Association Study Identifies New Genetic Determinants of Cardiorespiratory Fitness: The HUNT StudyMedicine and science in sports and exercise.

Taraldsen, M. D., Wiseth, R., Videm, V., Bye, A., & Madssen, E. (2022). Associations between circulating microRNAs and coronary plaque characteristics: potential impact from physical exercisePhysiological Genomics.

Nodeland, M., Klevjer, M., Sæther, J., Giskeødegård, G., Bathen, T. F., Wisløff, U., & Bye, A. (2022). Atherogenic lipidomics profile in healthy individuals with low cardiorespiratory fitness: The HUNT3 fitness studyAtherosclerosis

2021:

Williams, C. J., Li, Z., Harvey, N., Lea, R. A., Gurd, B. J., Bonafiglia, J. T., Papadimitrou, I., Jacques, M., Croci, I., Stensvold, D., Wisløff, U., Taylor, J. L., Gajanand, T., Cox, E. R., Ramos, J. S., Fassett, R. B., Little, J. P., Francois, M. E., Hearon Jr, C. M., Sarma, S., Janssen, S. L. J. E., van Craenenbroeck, E. M., Beckers, P., Cornelissen, V. A., Howden, E. J., Keating, S. E., Yan, X., Bishop, D. J., Bye, A., Haupt, L. M., Griffiths, L. R., Ashton, K. J., Brown, M. A., Torquati, L., Eynon; N., & Coombes, J. S. (2021). Genome wide association study of response to interval and continuous exercise training: the Predict-HIIT studyJournal of Biomedical Science28(1), 1-15.

Rutkovskiy, A., Lyngbakken, M. N., Dahl, M. B., Bye, A., Pedersen, M. H., Wisløff, U., Christensen, G., Høiseth, A. D., Omland, T., & Røsjø, H. (2021). Circulating MicroRNA-210 Concentrations in Patients with Acute Heart Failure: Data from the Akershus Cardiac Examination 2 StudyClinical Chemistry.

2020:

Halle, K. K., Bakke, Ø., Djurovic, S., Bye, A., Ryeng, E., Wisløff, U., Andreassen, O. A., & Langaas, M. (2020): Computationally efficient familywise error rate control in genome‐wide association studies using score tests for generalized linear modelsScandinavian Journal of Statistics

Bye, A., Klevjer, M., Ryeng, E., Silva, G. J., Moreira, J. B. N., Stensvold, D., & Wisløff, U. (2020). Identification of novel genetic variants associated with cardiorespiratory fitnessProgress in Cardiovascular Diseases.

Gigante, B., Papa, L., Bye, A., Kunderfranco, P., Viviani, C., Roncarati, R., Briguori, C., de Faire, U., Bottai, M., & Condorelli, G. (2020). MicroRNA signatures predict early major coronary events in middle-aged men and womenCell death & disease11(1), 1-3.

2019:

Velle-Forbord, T., Eidlaug, M., Debik, J., Sæther, J. C., Follestad, T., Nauman, J., Gigante, B., Røsjø, H., Omland, T., Langaas, M., & Bye, A. (2019). Circulating microRNAs as predictive biomarkers of myocardial infarction: Evidence from the HUNT studyAtherosclerosis.

Williams, C. J., Gurd, B. J., Bonafiglia, J. T., Voisin, S. A. C., Li, Z., Harvey, N., Croci, I., Taylor, J. L., Gajanand, T., Ramos, J. S., Fassett, R. G., Little, J. P., Francois, M. E., Hearon Jr., C. M., Sarma, S., Janssen, S. L. J. E., Caenenbroeck, E. M. V., Beckers, P., Cornelissen, V. A., Pattyn, N., Howden, E. K., Keating, S. E., Bye, A., Stensvold, D., Wisløff, U., Papadimitriou, I., Yan, X., Bishop, D. J., Eynon, N., & Coombes, J., (2019). A multi-centre comparison of V̇O2peak trainability between interval training and moderate intensity continuous training. Frontiers in Physiology, 10, 19.

2018:

Thomsen, R. S., Nilsen, T. I. L., Haugeberg, G., Bye, A., Kavanaugh, A., & Hoff, M. (2018). Effect of high-intensity interval training on cardiovascular disease risk factors and body composition in psoriatic arthritis: a randomised controlled trialRMD Open, 4(2), e000729.

Bjørnland, T., Bye, A., Ryeng, E., Wisløff, U., & Langaas, M. (2018). Powerful extreme phenotype sampling designs and score tests for genetic association studiesStatistics in medicine.

2017:

Silva, G. J., Bye, A., el Azzouzi, H., & Wisløff, U. (2017). MicroRNAs as important regulators of exercise adaptationProgress in cardiovascular diseases, 60(1), 130-151.

2016:

Bye, A., Røsjø, H., Nauman, J., Silva, G. J., Follestad, T., Omland, T., & Wisløff, U. (2016). Circulating microRNAs predict future fatal myocardial infarction in healthy individuals–The HUNT study. Journal of molecular and cellular cardiology, 97, 162-168.

2015:

Sandstad, J., Stensvold, D., Hoff, M., Nes, B. M., Arbo, I., & Bye, A. (2015). The effects of high intensity interval training in women with rheumatic disease: a pilot study. European journal of applied physiology, 115(10), 2081-2089.

Wisløff, U., Bye, A., Stølen, T., Kemi, O. J., Pollott, G. E., Pande, M., McEachin, R. C., Britton, S. L., & Koch, L. G. (2015). Blunted cardiomyocyte remodeling response in exercise-resistant rats. Journal of the American College of Cardiology, 65(13), 1378-1380.

Moreira, J. B., Wohlwend, M., Alves, M. N., Wisløff, U., & Bye, A. (2015). A small molecule activator of AKT does not reduce ischemic injury of the rat heart. Journal of translational medicine, 13(1), 1-10.

2014:

Slagsvold, K. H., Moreira, J. B., Rognmo, Ø., Høydal, M., Bye, A., Wisløff, U., & Wahba, A. (2014). Remote ischemic preconditioning preserves mitochondrial function and activates pro-survival protein kinase Akt in the left ventricle during cardiac surgery: a randomized trial. International journal of cardiology, 177(2), 409-417.

Røsjø, H., Dahl, M. B., Bye, A., Andreassen, J., Jørgensen, M., Wisløff, U., Christensen, G., Edvardsen, T., & Omland, T. (2014). Prognostic value of circulating microRNA-210 levels in patients with moderate to severe aortic stenosis. PLoS One, 9(3), e91812.

2013:

Bye, A., Røsjø, H., Aspenes, S. T., Condorelli, G., Omland, T., & Wisløff, U. (2013). Circulating microRNAs and aerobic fitness–the HUNT-Study. PloS one, 8(2), e57496.


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