Gastrin Systems Biology
The gut hormone Gastrin is an important pleiotropic response modifier that affects many biological processes, cellular differentiation and function, and the development of various diseases. Adequate models explaining how Gastrin acts as a response modifier are essential to understand its role in proliferation and migration. Biological systems are driven by complex processes, representing a significant analysis and modelling challenge. Modern molecular medicine's major challenges lie in developing new strategies for genome-wide data acquisition and analysis coupled with improved knowledge management, including new methods for generation of predictive models that capture essential laws, patterns and principles of biological systems. Systems biology offers a way forward in this direction.
Some first results:
Cytoscape map of the Gastrin/Cholecystokinin hormone mediated signaling network:
model title: CCKR_290312
We are currently emgaged in an effort to enhance the knowledge in databases about DNA binding transcription factors (DbTFs), the first results of this can be seen at www.tfcheckpoint.org.
The Gastrin Systems Biology project crosses faculties and binds various research groups together. The main participants in this project are:
The Department of Cancer research and Molecular medicine / Faculty of Medicine and Health:
Astrid Lægreid – project leader Gastrin Systems Biology
Liv Thommesen - project leader
Torunn Bruland - Postdoctoral scientist
Sushil Tripathi – PhD student
Åsmund Flobak - PhD student
The Department of Biology / Faculty of Natural Sciences and Technology (NT):
Vladimir Mironov – Senior Scientist
Aravind Venkatesan – PhD student